Endogenous Serotonin Contributes to a Developmental Decrease in Long-Term Potentiation in the Rat Visual Cortex

Edagawa, Yoshikuni; Saito, Hiroshi; Abe, Kazuho

doi:10.1523/jneurosci.21-05-01532.2001

Cited by 50 publications

(37 citation statements)

References 37 publications

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“…Thus, the critical period of layer IV plasticity likely involves changes downstream from the activation of NMDARs. In layer II/III, however, we propose that the machinery supporting synaptic plasticity is preserved in adults, but the induction is highly constrained by recruitment of inhibitory circuits and the action of neuromodulators (Edagawa et al, 2001;Kim et al, 2006), which may mask the ongoing presence of synaptic plasticity (Kirkwood et al, 1997;Yoshimura et al, 2003).…”

Section: Discussionmentioning

confidence: 93%

Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex

Jiang¹,

Treviño²,

Kirkwood³

2007

J. Neurosci.

112

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Section: Discussionmentioning

confidence: 93%

Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex

Jiang¹,

Treviño²,

Kirkwood³

2007

J. Neurosci.

112

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“…Modulating 5-HT levels increase cortical plasticity in the adult visual system (35,36). SRIs in particular can reopen cortical plasticity (37), but the means by which they do so has been largely undescribed.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Weikum

Oberlander

Hensch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

172

107

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Language acquisition reflects a complex interplay between biology and early experience. Psychotropic medication exposure has been shown to alter neural plasticity and shift sensitive periods in perceptual development. Notably, serotonin reuptake inhibitors (SRIs) are antidepressant agents increasingly prescribed to manage antenatal mood disorders, and depressed maternal mood per se during pregnancy impacts infant behavior, also raising concerns about long-term consequences following such developmental exposure. We studied whether infants' language development is altered by prenatal exposure to SRIs and whether such effects differ from exposure to maternal mood disturbances. Infants from non-SRI-treated mothers with little or no depression (control), depressed but non-SRI-treated (depressed-only), and depressed and treated with an SRI (SRI-exposed) were studied at 36 wk gestation (while still in utero) on a consonant and vowel discrimination task and at 6 and 10 mo of age on a nonnative speech and visual language discrimination task. Whereas the control infants responded as expected (success at 6 mo and failure at 10 mo) the SRI-exposed infants failed to discriminate the language differences at either age and the depressed-only infants succeeded at 10 mo instead of 6 mo. Fetuses at 36 wk gestation in the control condition performed as expected, with a response on vowel but not consonant discrimination, whereas the SRI-exposed fetuses showed accelerated perceptual development by discriminating both vowels and consonants. Thus, prenatal depressed maternal mood and SRI exposure were found to shift developmental milestones bidirectionally on infant speech perception tasks.L anguage, our most quintessential human characteristic, involves a complex interplay between biology and experience. At birth, infants possess an initial preparedness for language and a developmental readiness that supports learning any of the world's languages (1-3), yet also already show privileged processing to the native language from prenatal listening experience (4-6). During the following weeks and months of life, infants become progressively attuned to the properties of their native language, including its rhythmical and segmental (e.g., consonant) information (reviewed in refs. 7 and 8). The high degree of regularity in the timing of sequential tuning to properties of the native language suggests a series of critical or sensitive periods, i.e., points in development when the system is maximally influenced by input.The timing of onset of these sensitive periods seems to be maturationally constrained. Infants born 3 mo preterm attune to the phonetic properties (9) of their native language at the same gestational age as full-term infants, not according to the number of months of postnatal listening experience. Such maturational constraints can protect development: ensuring the optimal consecutive stabilization of the perceptual components that contribute in a step-wise fashion to language acquisition (10). However, it is known from research i...

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“…5-HT is involved in OD plasticity [23] and also regulates synaptic plasticity in the visual cortex [24][25][26]. The developmental increase in 5-HT content has been correlated to an age-dependent decrease in LTP in the visual cortex [27]. These findings suggest important roles for 5-HT in the regulation of the critical period in visual cortical plasticity.…”

Section: Introductionmentioning

confidence: 89%

“…An increase in 5-HT content in the rat primary visual cortex during the critical period reportedly is important in the developmental decrease in LTP [27,29]. To further elucidate the role of 5-HT, the effect of 5-HT on LTD induction was investigated by bath application of 5-HT.…”

Section: -Ht Inhibition On the Induction Of Ltdmentioning

confidence: 99%

Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Jang

Cho

Park

et al. 2010

Korean J Physiol Pharmacol

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Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a developmental increase in serotonin [5-hydroxytryptamine (5-HT)] might be involved in the decline of LTP, since 5-HT inhibited its induction. In the present study, to further understand the role of 5-HT in a developmental decrease in plasticity, we investigated the effect of 5-HT on the induction of LTD in the pathway from layer 4 to layer 2/3. LTD was inhibited by 5-HT (10 μM) in 5-week-old rats. The inhibitory effect was mediated by activation of 5-HT2 receptors. Since 5-HT also regulates the development of visual cortical circuits, we also investigated the role of 5-HT on the development of inhibition. The development of inhibition was retarded by chronic (2 weeks) depletion of endogenous 5-HT in 5-week-old rats, in which LTD was reinstated. These results suggest that 5-HT regulates the induction of LTD directly via activation of 5-HT2 receptors and indirectly by regulating cortical development. Thus, the present study provides significant insight into the roles of 5-HT on the development of visual cortical circuits and on the age-dependent decline of long-term synaptic plasticity.

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Endogenous Serotonin Contributes to a Developmental Decrease in Long-Term Potentiation in the Rat Visual Cortex

Cited by 50 publications

References 37 publications

Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex

Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

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