Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System

Huang, Yaqian; Tang, Chaoshu; Du, Junbao; Jin, Hongfang

doi:10.1155/2016/8961951

Cited by 116 publications

(87 citation statements)

References 69 publications

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“…Moreover, these therapeutic molecules, as significant physiological messengers, can maintain the homeostasis of physiological functions in humans . Recently, a number of studies have indicated that sulfur dioxide (SO 2 ) produced by metabolic processes in the body plays a significant role in regulating the cardiovascular system . In addition, elevated concentration of SO 2 could regulate oxidative stress and could cause DNA damage, resulting in the death of cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Yao

Peng

et al. 2020

Adv Healthcare Materials

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Multiple drug resistance (MDR) exhibited by cancer cells and low intratumor accumulation of chemotherapeutics are the main obstacles in cancer chemotherapy. Herein, the preparation of a redox‐responsive sulfur dioxide (SO2)‐releasing nanosystem, with high SO2‐loading capacity, aimed at improving the treatment efficacy of cancers exhibiting MDR is described. The multifunctional nanomedicine (MON‐DN@PCBMA‐DOX) is designed and constructed by coating mesoporous organosilica nanoparticles with a zwitterionic polymer, poly(carboxybetaine methacrylate) (PCBMA), which can concurrently load SO2 prodrug molecules (DN, 2,4‐dinitrobenzenesulfonylchloride) and chemotherapeutics (DOX, doxorubicin). The generated SO2 molecules can sensitize cells to chemotherapy and overcome the MDR by downregulating the expression of P‐glycoprotein. Furthermore, the PCBMA coating prolongs the blood circulation time of the inner core, leading to an increased intratumor accumulation of the nanomedicine. Owing to the prolonged blood circulation, enhanced tumor accumulation, and SO2 sensitization of cells to chemotherapy, the nanomedicine exhibits excellent tumor suppression with a tumor inhibition rate of 94.8%, and might provide a new platform for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Yao

Peng

et al. 2020

Adv Healthcare Materials

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“…In addition to H 2 S as the sulfur‐containing gas, sulfur dioxide (SO 2 ) can also be generated in human body via the metabolic process originating from some sulfur‐containing amino acids in the body, such as l ‐cysteine and l ‐methionine. It has also been demonstrated that SO 2 is effective in regulating the cardiovascular system, but the large uptake of SO 2 would cause the severe oxidative damage to organism because of the GSH depletion and ROS generation . Based on the fact that SO 2 gas could enhance the ROS level in tumor cells and then reverse the MDR of cancer cells, Chen et al designed a small molecular prodrug of SO 2 , which was then self‐assembled into micelles with the responsiveness to GSH .…”

Section: Other Gas‐generating Ggns and Theranostic Applicationsmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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“…The endogenously generated sulfur-containing gases H2S and SO2 that are intermediates of the sulfate generating pathways (Fig. 1B), also contribute to numerous physiological and pathophysiological roles in the mammalian body (Medani et al, 2011;Wang et al, 2011;di Masi and Ascenzi, 2013;Wang et al, 2014;Guo et al, 2016;Huang et al, 2016). In particular, both H2S and SO2 modulate vascular tone and cardiac function, and have cardioprotective effects in animal models of systemic and pulmonary hypertension, atherosclerosis and cardiac ischemia-reperfusion injury (Elrod et al, 2007;di Masi and Ascenzi, 2013;Wang et al, 2014).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Genetics and pathophysiology of mammalian sulfate biology

Langford

Hurrion

Dawson

2017

Journal of Genetics and Genomics

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Nutrient sulfate is essential for numerous physiological functions in mammalian growth and development. Accordingly, disruptions to any of the molecular processes that maintain the required biological ratio of sulfonated and unconjugated substrates are likely to have detrimental consequences for mammalian physiology. Molecular processes of sulfate biology can be broadly grouped into four categories: firstly, intracellular sulfate levels are maintained by intermediary metabolism and sulfate transporters that mediate the transfer of sulfate across the plasma membrane; secondly, sulfate is converted to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), which is the universal sulfonate donor for all sulfonation reactions; thirdly, sulfotransferases mediate the intracellular sulfonation of endogenous and exogenous substrates; fourthly, sulfate is removed from substrates via sulfatases. From the literature, we curated 91 human genes that encode all known sulfate transporters, enzymes in pathways of sulfate generation, PAPS synthetases and transporters, sulfotransferases and sulfatases, with a focus on genes that are linked to human and animal pathophysiology. The predominant clinical features linked to these genes include neurological dysfunction, skeletal dysplasias, reduced fecundity and reproduction, and cardiovascular pathologies. Collectively, this review provides reference information for genetic investigations of perturbed mammalian sulfate biology.

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Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System

Cited by 116 publications

References 69 publications

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Genetics and pathophysiology of mammalian sulfate biology

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