Endogenous Vasoactive Peptides and Vascular Aging-Related Diseases

Chen, Yao; Qi, Yongfen; Lu, Weiwei

doi:10.1155/2022/1534470

Cited by 3 publications

(1 citation statement)

References 160 publications

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“…For example, the presence of certain peptides or other chemicals may influence endothelial cell behavior. 79,80 For example, RGD peptide, or arginine-glycyl-aspartic acid, is noted for promoting adhesion in endothelial cells when attached to various material surfaces. 81 Similarly, the presence of certain growth factors, such as VEGF, may encourage migration and angiogenesis.…”

Section: Developments and Advancesmentioning

confidence: 99%

Vascularized microfluidic models of major organ structures and cancerous tissues

Rama Varma,

Fathi

2023

Biomicrofluidics

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Organ-on-a-chip devices are powerful modeling systems that allow researchers to recapitulate the in vivo structures of organs as well as the physiological conditions those tissues are subject to. These devices are useful tools in modeling not only the behavior of a healthy organ but also in modeling disease pathology or the effects of specific drugs. The incorporation of fluidic flow is of great significance in these devices due to the important roles of physiological fluid flows in vivo. Recent developments in the field have led to the production of vascularized organ-on-a-chip devices, which can more accurately reproduce the conditions observed in vivo by recapitulating the vasculature of the organ concerned. This review paper will provide a brief overview of the history of organ-on-a-chip devices, before discussing developments in the production of vascularized organs-on-chips, and the implications these developments hold for the future of the field.

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Section: Developments and Advancesmentioning

confidence: 99%

Vascularized microfluidic models of major organ structures and cancerous tissues

Rama Varma,

Fathi

2023

Biomicrofluidics

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The Potential Role of Soybean Bioactive Peptides in the Prevention and Cure of Carcinoma and Cardiovascular Disorder

Singh,

Gupta,

Kumar

et al. 2024

CBC

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Bioactive peptides derived from soybeans have recently been identified as having potential health benefits for preventing and curing cancer and cardiovascular disorders. This narrative review focuses on the potential role of these peptides in such conditions and the possible mechanisms by which they may act. Soybean-derived bioactive peptides have been found to possess antitumor, antioxidant, anti-inflammatory, and cholesterol-lowering effects. Animal and in vitro studies have demonstrated that these peptides can modulate multiple signaling pathways, including those involved in the regulation of apoptosis, angiogenesis, and cell proliferation. Furthermore, they may protect against oxidative stress and lipid accumulation, which are associated with cancer and cardiovascular diseases. Also, soybean peptides have been shown to stop enzymes from breaking down cancer-causing chemicals and reduce the production of pro-inflammatory cytokines, which are linked to a higher risk of heart disease. The potential of soybean-derived peptides as a therapeutic tool in cancer and cardiovascular diseases is promising. However, further studies are needed to elucidate their mechanisms of action and assess their safety and efficacy in clinical settings.

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Molecular Mechanisms of Plant Extracts in Protecting Aging Blood Vessels

Luo,

Zhang,

Zheng

et al. 2024

Nutrients

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Plant Extracts (PE) are natural substances extracted from plants, rich in various bioactive components. Exploring the molecular mechanisms and interactions involved in the vascular protective effects of PE is beneficial for the development of further strategies to protect aging blood vessels. For this review, the content was obtained from scientific databases such as PubMed, China National Knowledge Infrastructure (CNKI), and Google Scholar up to July 2024, using the search terms “Plant extracts”, “oxidative stress”, “vascular aging”, “endothelial dysfunction”, “ROS”, and “inflammation”. This review highlighted the effects of PE in protecting aging blood vessels. Through pathways such as scavenging reactive oxygen species, activating antioxidant signaling pathways, enhancing respiratory chain complex activity, inhibiting mitochondrial-reactive oxygen species generation, improving nitric oxide bioavailability, downregulating the secretion of inflammatory factors, and activating sirtuins 1 and Nrf2 signaling pathways, it can improve vascular structural and functional changes caused by age-related oxidative stress, mitochondrial dysfunction, and inflammation due to aging, thereby reducing the incidence of age-related cardiovascular diseases.

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Endogenous Vasoactive Peptides and Vascular Aging-Related Diseases

Cited by 3 publications

References 160 publications

Vascularized microfluidic models of major organ structures and cancerous tissues

Vascularized microfluidic models of major organ structures and cancerous tissues

The Potential Role of Soybean Bioactive Peptides in the Prevention and Cure of Carcinoma and Cardiovascular Disorder

Molecular Mechanisms of Plant Extracts in Protecting Aging Blood Vessels

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