Endogenously produced hydrogen sulfide is involved in porcine oocyte maturation in vitro

Nevoral, Jan; Žalmanová, Tereza; Zámostná, Kateřina; Kott, T.; Kucerova-Chrpova, Veronika; Bodart, Jean‐François; Gelaude, Armance; Procházka, Radek; Orsák, Matyáš; Šulc, Miloslav; Klein, Pavel; Dvořáková, Markéta; Weingartova, Ivona; Víghová, Aurélia; Hošková, Kristýna; Krejcova, Tereza; Jílek, F.; Petr, Jaroslav

doi:10.1016/j.niox.2015.09.007

Cited by 15 publications

(20 citation statements)

References 44 publications

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“…In contrast to NO, little is known about H 2 S and S-sulfhydration involvement in gametogenesis and embryonic development. Nevertheless, all three H 2 S-releasing enzymes, CBS, CSE, and 3-MPST, were observed in porcine oocyte and surrounding cumulus cells [59]. This observation is in accordance with earlier finding of H 2 S involvement in folliculogenesis and oocyte maturation [19, 20].…”

Section: Gasotransmission In Female Reproductive Processessupporting

confidence: 89%

“…In addition, there is the observation of a protective effect of H 2 S against oocyte aging and H 2 S-positively affected further embryonic development [60]. Physiological action of endogenously released H 2 S immediately in oocyte has been described and modified kinase activity of MPF and MAPK has been observed [20, 59, 60]. S-sulfhydration of these kinases and their upregulated factors are presumable.…”

Section: Gasotransmission In Female Reproductive Processesmentioning

confidence: 99%

“…Moreover, NO plays a role in the second meiotic block release and oocyte activation [42, 43, 114]. The suppression of H 2 S physiological production even leads to oocyte maturation failure [59]. Therefore, precise supplementation of NO and H 2 S allows optimizing fertilization conditions [112] as well as relieving embryonic development defects.…”

Section: Perspectives Of Gasotransmitters For Assisted Reproductivmentioning

confidence: 99%

“…In general, presence of NO and H 2 S has been reported in mammalian oocytes and embryos as well [32, 59, 144] and their cross-talk due to S-nitrosylation and sulfhydration was reported, where their necessity is assumed. Meanwhile, there is poor knowledge of all gasotransmitters' potentiality, for example, (a) direct H 2 S-derived S-sulfhydration of core histones, (b) NO/H 2 S/SIRT1 axis, leading to chromatin equilibrium between an adequate transcriptional gene activity and genome stability, and (c) absent knowledge of CO involvement in epigenetics-driven embryogenesis.…”

Section: Perspectives Of Gasotransmitters For Assisted Reproductivmentioning

confidence: 99%

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Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

Nevoral

Bodart²,

Petr

2016

Oxidative Medicine and Cellular Longevity

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Creation of both gametes, sperm and oocyte, and their fusion during fertilization are essential step for beginning of life. Although molecular mechanisms regulating gametogenesis, fertilization, and early embryonic development are still subjected to intensive study, a lot of phenomena remain unclear. Based on our best knowledge and own results, we consider gasotransmitters to be essential for various signalisation in oocytes and embryos. In accordance with nitric oxide (NO) and hydrogen sulfide (H2S) physiological necessity, their involvement during oocyte maturation and regulative role in fertilization followed by embryonic development have been described. During these processes, NO- and H2S-derived posttranslational modifications represent the main mode of their regulative effect. While NO represent the most understood gasotransmitter and H2S is still intensively studied gasotransmitter, appreciation of carbon monoxide (CO) role in reproduction is still missing. Overall understanding of gasotransmitters including their interaction is promising for reproductive medicine and assisted reproductive technologies (ART), because these approaches contend with failure of in vitro assisted reproduction.

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Section: Gasotransmission In Female Reproductive Processessupporting

confidence: 89%

Section: Gasotransmission In Female Reproductive Processesmentioning

confidence: 99%

Section: Perspectives Of Gasotransmitters For Assisted Reproductivmentioning

confidence: 99%

Section: Perspectives Of Gasotransmitters For Assisted Reproductivmentioning

confidence: 99%

See 2 more Smart Citations

Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

Nevoral

Bodart²,

Petr

2016

Oxidative Medicine and Cellular Longevity

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“…Samples were prepared in accordance with previous study 58 . Briefly, denuded GV oocytes (200 per sample) were placed into 15 µL of sample buffer.…”

Section: Methodsmentioning

confidence: 99%

Bisphenol S negatively affects the meotic maturation of pig oocytes

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2017

Sci Rep

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Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced.

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A benzothiazole-based fluorescent probe for selective detection of H 2 S in living cells and mouse hippocampal tissues

et al. 2017

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Endogenously produced hydrogen sulfide is involved in porcine oocyte maturation in vitro

Cited by 15 publications

References 44 publications

Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

Bisphenol S negatively affects the meotic maturation of pig oocytes

A benzothiazole-based fluorescent probe for selective detection of H 2 S in living cells and mouse hippocampal tissues

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