2012
DOI: 10.1007/s00125-012-2765-0
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Endoglin (CD105) is not a specific selection marker for endothelial cells in human islets of Langerhans. Reply to Wheeler-Jones CPD, Clarkin CE, Farrar CE et al [letter]

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“…Regarding these proteins CD105 (endoglin) corresponds to a glycoprotein of the cell membrane, which is a receptor for transforming growth factor beta-1 and beta-3. It is mainly expressed in vascular endothelial cells, the syncytiumtrophoblast, and to a lesser extent in monocytes, fibroblasts and chondrocytes [ 145 ]. Additionally, CD90 (Thy-1 cell surface antigen THY1) is a protein that is bound to glycophosphatidylinositol, present in intercellular interactions [ 146 ].…”
Section: Discussionmentioning
confidence: 99%
“…Regarding these proteins CD105 (endoglin) corresponds to a glycoprotein of the cell membrane, which is a receptor for transforming growth factor beta-1 and beta-3. It is mainly expressed in vascular endothelial cells, the syncytiumtrophoblast, and to a lesser extent in monocytes, fibroblasts and chondrocytes [ 145 ]. Additionally, CD90 (Thy-1 cell surface antigen THY1) is a protein that is bound to glycophosphatidylinositol, present in intercellular interactions [ 146 ].…”
Section: Discussionmentioning
confidence: 99%