Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study

Clifford, K.; Flanagan, Adrienne M.; Regan, Lesley

doi:10.1093/humrep/14.11.2727

Cited by 202 publications

(121 citation statements)

References 28 publications

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“…Furthermore, numbers of uNK cells have been reported to be altered in pre-eclampsia (Williams et al 2009), although results are inconsistent, and several groups have reported increased uNK cells in mid-secretoryphase endometrium from women with a history of recurrent miscarriage or recurrent implantation failure (Clifford et al 1999, Laird et al 2003, Quenby & Farquharson 2006. As the uNK cells are the predominant decidual leukocyte population in early pregnancy, many roles have been suggested for them.…”

Section: Decidual/uterine Nk Cellsmentioning

confidence: 99%

Immunological role of vitamin D at the maternal–fetal interface

Tamblyn¹,

Hewison²,

Wagner³

et al. 2015

Journal of Endocrinology

153

104

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Section: Decidual/uterine Nk Cellsmentioning

confidence: 99%

Immunological role of vitamin D at the maternal–fetal interface

Tamblyn¹,

Hewison²,

Wagner³

et al. 2015

Journal of Endocrinology

153

104

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“…For example, increased numbers of CD56+ NK cells have been reported in decidua of women with sporadic miscarriage compared with controls (Zenclussen et al, 2001), although we were not able to confirm this finding in a study of placental bed biopsies from aneuploid and euploid miscarriages from 8 -20 weeks gestation, compared with normal pregnancy (Scaife et al, 2004). Despite the inconsistency of data for decidual and peripheral blood leukocytes, there are several independent reports from different groups of increased numbers of uNK cells, detected using immunohistochemistry, in luteal phase endometrium of both women with unexplained recurrent miscarriage and recurrent implantation failure (Quenby et al, 1999;Clifford et al, 1999;Laird et al, 2005;Tuckerman et al, 2007). Furthermore, it has been suggested that high uNK cell numbers in mid-secretory phase endometrium from women with recurrent miscarriage predicted miscarriage in subsequent pregnancy (Quenby et al, 1999).…”

Section: Uterine Nk Cells In Pathological Pregnancymentioning

confidence: 99%

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

319

280

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“…CD56 + CD16 + uNK cells were found in 85% [68/80] of the studied decidua specimens of women with unexplained repeated miscarriage. Quenby et al (16) reported that women with RM had significantly more uNK than controls, and Clifford et al (37) also showed increased CD56+ uK cells in women with unexplained repeated miscarriage. Increased expression of CD56 + CD16 + uNK was also reported in deciduas obtained after spontaneous miscarriage in women with a history of repeated miscarriage (38 Women refused to participate in the study and the use of tissue culture and conventional G-banding for cytogenic analysis and karyotyping of abortion specimens were limitations during this study.…”

Section: Discussionmentioning

confidence: 99%

Relationship between uterine natural killer cells and unexplained repeated miscarriage

Farghali

Elkholy

Swidan

et al. 2015

J Turkish German Gynecol Assoc

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Objective:To evaluate the relation between uterine killer (uK) cells and unexplained repeated miscarriage (RM). Material and Methods: Eighty women with unexplained repeated miscarriage and missed miscarriage of current pregnancy were studied.Fetal viability and gestational age of the current pregnancy were confirmed by ultrasound, followed by suction evacuation to collect abortion specimens and uterine wall curettage to collect decidua specimens. Abortion specimens were collected for long-term monolayer cell culture and subsequent chromosome analysis using conventional G-banding. Decidua specimens were subjected to immunohistochemical staining using monoclonal antibodies specific to CD56+ and CD16+ expressed by uK cells.Results: CD56+ CD16+ uK cells were found in 85% [68/80] of the studied decidua specimens of women with unexplained repeated miscarriage; 88.5% [54/61] had normal abortion karyotyping and 73.7% [14/19] had abnormal abortion karyotyping. Moreover, 73.75% [59/80] of the studied women with a past history of early miscarriage had CD56+ CD16+ uK cells in their decidua specimens, and 66.25% [53/80] of studied women with a past history of late miscarriage had CD56+ CD16+ uK cells in their decidua specimens; the association between early and late miscarriage and CD56+ CD16+ uK cells in decidua specimens was significant. Conclusion:CD56+CD16+ uK cells were predominant in the decidua specimens of the studied women with repeated miscarriage. A significant association was found between the presence of CD56+ CD16+ uK cells in the studied decidua specimens and unexplained repeated miscarriage. (J Turk Ger Gynecol Assoc 2015; 16: 214-8) Keywords: Obstetrics, uterine killer cells, repeated miscarriage Received: 27 April, 2015 Accepted: 14 October, 2015 Relationship between uterine natural killer cells and unexplained repeated miscarriage Material and MethodsEighty women with unexplained repeated miscarriage and missed miscarriage of current pregnancy were included for evacuation and curettage because of a current missed miscarriage (>8 weeks, diagnosed by ultrasound). The women were studied after proper counseling, consent, and approval of the ethical committee. Unexplained repeated miscarriage was defined as ≥2 previous miscarriages after <20 weeks' gestation. A thorough history was obtained and a thorough examination was performed for all studied women, followed by trans-vaginal ultrasound to confirm fetal the viability and gestational age of the current pregnancy by a sonographer who was blinded to the patients' data. Peripheral venous samples were collected from the studied women for oral glucose tolerance tests; thyroid stimulating hormone assays; prolactin, serum anticardiolipin, and lupus anticoagulant assays; as well as activated protein C resistance tests, Leiden factor V and prothrombin gene mutations, and protein C, S, and anti-thrombin III deficiency tests. Women with septic miscarriage, documented endocrinopathies (diabetes, thyroid disorders, or hyperprolactinemia), uterine anomalies, p...

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Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study

Cited by 202 publications

References 28 publications

Immunological role of vitamin D at the maternal–fetal interface

Immunological role of vitamin D at the maternal–fetal interface

Immune cells in the placental bed

Relationship between uterine natural killer cells and unexplained repeated miscarriage

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