Endometrial Immune-Inflammatory Gene Signatures in Endometriosis

T helper 17 axis and endometrial macrophage disruption in menstrual effluent provides potential insights into the pathogenesis of endometriosis

“…On the basis of global immune transcriptomic profiles of endometriotic lesions, eutopic endometrium of patients, and endometrium from healthy, fertile controls, endometriotic lesions have unique immune gene signatures, specifically in the expression of genes for adhesion, inflammation, and implantation (7,(14)(15)(16). Keeping this in view, we hypothesized that the ME of patients with endometriosis will reveal distinct Tcell subsets and cytokine profiles.…”

Investigating Infection's Role as a Contributing Factor in the Genetic and Epigenetic Mechanisms of Endometriosis: A Narrative Review.

“…Recent studies have begun to unravel the genetic underpinnings that link endometriosis with an enhanced immune response to infections. This connection is particularly evident in the identification of specific genetic markers associated with both an increased risk of endometriosis and a heightened immune reaction to infectious agents [6]. Such findings suggest that individuals with these genetic markers may be predisposed to both the development of endometriosis and an amplified inflammatory response to infections, potentially creating a vicious cycle that exacerbates the condition.…”

“…Furthermore, the association between TLR4 gene variants and endometriosis underscores the complex interplay between the immune system and endometriosis pathogenesis. It suggests that the immune system's dysregulation, influenced by genetic factors, maybe a critical component in the disease's development and progression [8]. This insight opens new avenues for research into targeted therapies that address the underlying genetic and immunological factors contributing to endometriosis, potentially offering more effective treatment strategies for those affected by the condition.…”