Endometrial Receptivity Array—A Promising Remedy for Women Afflicted with Recurrent Implantation Failure: A Case Report

Abstract

Aim and background: An endometrial receptivity array (ERA) is a test for assessing the endometrium's gene expression profile concerning receptivity for embryo implantation. The primary significance of the ERA test is its ability to objectively assess the window of implantation (WOI), thereby facilitating the development of the personalized embryo transfer (pET) concept. Case description: A patient, aged 38 years, married for 16 years, a case of secondary infertility, had three unsuccessful attempts of intrauterine insemination and six unsuccessful attempts of In vitro fertilization (IVF). Given her history of recurrent implantation failures (RIF), she underwent the ERA test. The ERA indicated a pre-receptive result. She conceived in the very first attempt of ERA-guided pET. The patient delivered a female child at 34 weeks by a lower segment cesarean section. Conclusion:The ERA test accurately and sensitively identifies endometrial gene expressions, enabling the decision of the most suitable time for embryo transfer. Clinical significance: In vitro fertilization success rates could rise if the endometrial factor were personalized using an objective and reproducible diagnostic method like ERA in RIF patients.