Endometrial scratching: less invasive methods should be tried first

Tesarik, Jan

doi:10.1016/j.rbmo.2022.05.008

Cited by 2 publications

(1 citation statement)

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“…Intrauterine injection of PRP was successfully applied for the first time in 2015 as an intervention for improving the refractory endometrium of women to receive IVF [ 148 ], and since then, promising results were reported in three randomized controlled trials (reviewed in [ 149 ]). These data have led to the suggestion to replace endometrial scratching with GH and PRP treatments as the first-line approach to RIF and early miscarriages [ 150 ].…”

Section: Clues To Possible Treatment Optionsmentioning

confidence: 99%

Molecular Clues to Understanding Causes of Human-Assisted Reproduction Treatment Failures and Possible Treatment Options

Mendoza-Tesarik¹

2022

IJMS

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More than forty years after the first birth following in vitro fertilization (IVF), the success rates of IVF and of IVF-derived assisted reproduction techniques (ART) still remain relatively low. Interindividual differences between infertile couples and the nature of the problems underlying their infertility appear to be underestimated nowadays. Consequently, the molecular basis of each couple’s reproductive function and of its disturbances is needed to offer an individualized diagnostic and therapeutic approaches to each couple, instead of applying a standard or minimally adapted protocols to everybody. Interindividual differences include sperm and oocyte function and health status, early (preimplantation) embryonic development, the optimal window of uterine receptivity for the implanting embryo, the function of the corpus luteum as the main source of progesterone production during the first days of pregnancy, the timing of the subsequent luteoplacental shift in progesterone production, and aberrant reactions of the uterine immune cells to the implanting and recently implanted embryos. In this article, the molecular basis that underlies each of these abnormalities is reviewed and discussed, with the aim to design specific treatment options to be used for each of them.

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Section: Clues To Possible Treatment Optionsmentioning

confidence: 99%

Molecular Clues to Understanding Causes of Human-Assisted Reproduction Treatment Failures and Possible Treatment Options

Mendoza-Tesarik¹

2022

IJMS

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Endometrial scratching and intralipid treatment—no general recommendations

Mrosk,

Sandi-Monroy,

Gagsteiger

et al. 2024

Front. Reprod. Health

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ObjectivesEndometrial scratching (ES) and/or intravenous intralipid therapy (in cases of increased uterine natural killer cells, uNKs) are still conducted in several fertility centers as “add-on” treatments in patients undergoing ART, although convincing evidence for beneficial effects is lacking.Study designIn this retrospective study, associations between ES treatment or additional intralipid therapy and pregnancy and live birth rates of 1,546 patients undergoing 2,821 IVF-/ICSI-treatment cycles with fresh or frozen embryo transfers in a German fertility-center between 1st January 2014 and 31th May 2017 were analyzed.ResultsOverall pregnancy and live birth rates for all 2,821 treatment cycles (468 cycles with ES) were 32.8% and 23.5%. There were no statistically significant differences in pregnancy or live birth rates between first treatment cycles with and without ES (p = 0.915 and p = 0.577) or between second cycles following an unsuccessful first cycle with and without ES (p = 0.752 and p = 0.623). These results were confirmed using multivariable generalized estimating equations (GEE) models accounting for non-independency of multiple treatment cycles per patients that included all cycles and showed no significant effect of ES on pregnancy (p = 0.449) or live birth rates (p = 0.976). Likewise, a GEE model revealed no significant effect of intralipid treatment on pregnancy (p = 0.926) and live birth rates (p = 0.727).ConclusionsOur results reveal no evidence that ES increases the pregnancy or live birth rates in women undergoing their first or further IVF cycle with fresh or frozen embryo transfer. Intralipid treatment was also not beneficial. Even if patients explicitly ask for it, these procedures are not recommended outside of clinical studies.

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Endometrial scratching: less invasive methods should be tried first

Cited by 2 publications

References 4 publications

Molecular Clues to Understanding Causes of Human-Assisted Reproduction Treatment Failures and Possible Treatment Options

Molecular Clues to Understanding Causes of Human-Assisted Reproduction Treatment Failures and Possible Treatment Options

Endometrial scratching and intralipid treatment—no general recommendations

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