Endometrial stem cells in regenerative medicine

Verdi, Javad; Tan, Aaron; Shoae-Hassani, Alireza; Seifalian, Alexander M.

doi:10.1186/1754-1611-8-20

Cited by 68 publications

(70 citation statements)

References 93 publications

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“…These cells are probably responsible for the regenerative capacity of the endometrium. Epithelial stem cells might be located in the basal layer of the endometrium [138]. Stem cells can be classified as embryonic stem cells [139], germ stem cells [140], fetal stem cells [141], cancer stem cells (CSCS) and EmCa side population cells (ECSP) as well as somatic or adult stem cells [142, 143].…”

Section: Cancer Stem Cellsmentioning

confidence: 99%

Molecular cues on obesity signals, tumor markers and endometrial cancer

Daley-Brown¹,

Oprea‐Ilies²,

Lee³

et al. 2015

Hormone Molecular Biology and Clinical Investigation

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Tumor markers are important tools for early diagnosis, prognosis, therapy response and endometrial cancer monitoring. A large number of molecular and pathologic markers have been described in types I and II endometrial cancers, which has served to define the main oncogenic, epidemiological, genetic, clinical and histopathological features. Ongoing attempts to stratify biological markers of endometrial cancer are presented. However, data on changes in tumor marker profiles in obesity-related endometrial cancer are scarce. Obesity is a pandemic in Western countries that has an important impact on endometrial cancers, albeit through not very well-defined mechanisms. Although endometrial cancer is more common in Caucasian women, higher mortality is found in African Americans who also show higher incidence of obesity. Here, we describe how obesity signals (estrogen, leptin, leptin induced-molecules, Notch; cytokines and growth factors) could affect endometrial cancer. Leptin signaling and its crosstalk may be associated to the more aggressive and poor prognosis type II endometrial cancer, which affects more postmenopausal and African-American women. In this regard, studies on expression of novel molecular markers (Notch, interleukin-1 and leptin crosstalk outcome) may provide essential clues for detection, prevention, treatment and prognosis.

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Section: Cancer Stem Cellsmentioning

confidence: 99%

Molecular cues on obesity signals, tumor markers and endometrial cancer

Daley-Brown¹,

Oprea‐Ilies²,

Lee³

et al. 2015

Hormone Molecular Biology and Clinical Investigation

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“…13,16,17 In utero transfer of SCs for management of congenital disease is under research. 18 Menstrual blood is a potential source for obtaining autologus stem cell in future as observed in the study of Patel at al.…”

Section: Discussionmentioning

confidence: 99%

Chronic cervicitis: role of adult autologus stem cells

Jain¹,

Jain²

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Stem cells are biological cells found in all multi-cellular organisms and capable to differentiate into diverse specialized cell types and self-renew to produce more stem cells. Stem cells act as immuno-modulatory, angiogenetic, cell repairing and cell protecting agents. They also have strong anti-inflammatory effect due to paracrine action of trophic factors release. Chronic cervicitis is very common disease of adult women worldwide, chronic infection and inflammation of the cervix is hard to cure with high recurrence rate leading to long term consequences like pelvic inflammatory disease, infertility, ectopic pregnancy, chronic pelvic pain, increased predisposition to HPV and HIV infection and even can be a precursor of cervical cancer.Methods: To show the therapeutic and symptomatic benefits of these cells in chronic cervicitis we injected 10 patients with adult autologus stem cells (AASCs) locally in the cervix, and PRP, growth factors IV. All the cells were harvested from bone marrow after bone marrow aspiration.Results: Clinical benefits were evident on follow up visits in the entire treated patient. All the patient had shown improvement in symptoms like continuous malodourous discharge, dyspariunea, pelvic pain and pressure, backache, itching and burning, post coital bleeding.Conclusions: Present study have shown that AASCs and growth factors is a safe effective ethical and viable option not only to cure the disease but also in improving the quality of life of a woman and protecting her from its significant consequences.

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“…45 Recently, autologous tissue engineered scaffolds using artificial meshes and E-MSCs were prepared for regenerative therapy. 46 They were demonstrated to be suitable for fascial repair. 47 E-MSCs enhance neovascularization, reduce chronic inflammation, support tissue integration -likely because of their capability to modulate tissue response toward foreign materials -and promote distensibility of the artificial mesh.…”

Section: Endometrium Mesenchymal Stem Cells (E-mscs)mentioning

confidence: 99%

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

et al. 2015

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(2015) Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds, Organogenesis, 11:4, 183-206, DOI: 10.1080/15476278.2015 ABSTRACT. Wound healing is a complex physiological process including overlapping phases (hemostatic/inflammatory, proliferating and remodeling phases). Every alteration in this mechanism might lead to pathological conditions of different medical relevance. Treatments for chronic nonhealing wounds are expensive because reiterative treatments are needed. Regenerative medicine and in particular mesenchymal stem cells approach is emerging as new potential clinical application in wound healing. In the past decades, advance in the understanding of molecular mechanisms underlying wound healing process has led to extensive topical administration of growth factors as part of wound care. Currently, no definitive treatment is available and the research on optimal wound care depends upon the efficacy and cost-benefit of emerging therapies.Here we provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and Systemic Sclerosis-associated ulcers, which are particularly challenging. Current and future treatment approaches are discussed with an emphasis on recent advances.

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Endometrial stem cells in regenerative medicine

Cited by 68 publications

References 93 publications

Molecular cues on obesity signals, tumor markers and endometrial cancer

Molecular cues on obesity signals, tumor markers and endometrial cancer

Chronic cervicitis: role of adult autologus stem cells

Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds

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