Endometrial stromal sarcoma: An aggressive uterine malignancy

Adiga, Chaitra Parameshwara; Gyanchandani, M; Goolahally, Lakshmikantha N; Itagi, Rishikesh M; Kalenahalli, Kiran V

doi:10.3941/jrcr.v10i9.2770

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…13 It comprises less than 10% to 15% of uterine sarcomas. 14 Diagnosis is made with tissue pathology. Histopathology is characterized by stromal cells, high mitotic figures, and areas of necrosis (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…13 Prognosis is poor for these patients. 14,13 An 11% 5-year survival rate has been reported for patients with distant metastasis. 13 Clinical presentation of lesions of the skull base is dependent upon the type and location of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…13 Prognosis is poor for these patients. 14,13 An 11% 5-year survival rate has been reported for patients with distant metastasis. 13…”

Section: Discussionmentioning

confidence: 99%

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Endometrial Sarcoma Metastasis to the Pterygopalatine Fossa: A Case Report and Review of the Literature

et al. 2021

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Metastatic skull base malignancies infrequently occur but, when present, typically arise from breast malignancies. Pterygopalatine fossa (PPF) metastasis of any malignancy is further seldom reported, and metastasis of gynecologic malignancies to the PPF has not been previously described in the literature. We present a single case of a 42-year-old female with the first likely case of high-grade endometrial sarcoma metastatic to the PPF. The patient presented with facial pain and numbness in the V2 distribution presented for evaluation. History was significant for several months of dysmenorrhea and metrorrhagia. Computed tomography, magnetic resonance imaging, and positron emission tomography imaging revealed a PPF mass with local extension and bony metastases. Endoscopic biopsy was performed, and final pathology was most consistent with metastatic high-grade endometrial stromal sarcoma. This is the first reported case of likely metastatic endometrial sarcoma to the PPF. This case report highlights the possibility of rare distant metastasis of gynecologic malignancy to this area of the skull base.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Endometrial Sarcoma Metastasis to the Pterygopalatine Fossa: A Case Report and Review of the Literature

et al. 2021

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“…Blood supply of malignant tumors occurs due to newly formed vessels, mainly capillary type, abnormal in form, chaotically located, having a deficiency of muscle tissue and a large number of arteriovenous anastomoses [17,18]. Blood flow in such vessels is characterized by high speed, low vascular resistance and various directions [19,20].…”

Section: The Importance Of the Study Of The Hemodynamics Of The Uterimentioning

confidence: 99%

The Importance of the Study of the Hemodynamics of the Uterine Tumors by the Method of Dopplerometry in the Two- And Three-Dimensional Echography Modes for Differential Diagnostics of Simple, Proliferating Leiomyomas and Uterine Sarcomas

Yakovenko¹,

Sukhin²,

Тамм

et al. 2018

EUREKA: Health Sciences

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The article analyzes modern literature data on the importance of studying the hemodynamics of uterine tumors with dopplerometry in two-and three-dimensional regimens of echography for differential diagnosis of simple proliferating leiomyomas and sarcomas of the uterus. It is shown that the differential diagnosis of benign and malignant tumors using the dopplerometry is based on various features of the blood supply of these tumors. On the basis of the analysis of literature data, it was concluded that in the dopplerometry evaluation of benign, borderline and malignant tumors of myometrium in the two-dimensional regime, there were differences in the localization of the detected vessels in the CDM regimen, in the rates of vascular blood flow and vascular resistance in pulse dopplerometry. For a simple leiomyoma, the absence of a central intra-node localization of blood vessels in the CDM regimen, a low rate of arterial and venous blood flow, as well as an average resistance of arterial blood flow in the regime of impulsive dopplerometry are most typical; in a leiomyoma with eating disorders, the absence of a central intra-node localization of blood vessels, a low rate of arterial and venous blood flow in combination with high arterial resistance were more often observed. For the proliferating leiomyoma, the central intra-node localization of the vessels and the average blood flow velocities with low and medium resistance are characteristic. For sarcoma of the uterus, there is abundant vascularization both around the periphery and in the center, high blood flow rates and low resistance. The authors emphasize that there is information about the low specificity of this gradation, since the detection of a central type of vascularization and low resistance values can be in simple myomatous nodes with edema, eating disorders and destruction, and leads to diagnostic errors and suspicion of malignancy. In the three-dimensional dopplerometry mode for simple leiomyomas, low indices of volume perfusion indices were characteristic, and for proliferating leiomyomas and sarcomas of the uterus-high indices of volume perfusion indices exceeding those in the uterus as a whole. Based on the review of the literature, the authors concluded that the presently available echographic and dopplerometric two-and three-dimensional markers are characterized by high sensitivity, but very low specificity. The low specificity of the known Reports on research projects (2018), «EUREKA: Health Sciences» Number 5 41 Medicine and Dentistry ultrasonic and dopplerometric criteria combined with the rarity of cases of sarcoma in the uterus against the background of a large number of similar echographically and dopplerometrically leiomyomas lead to low diagnostic accuracy of ultrasound diagnostics. This situation requires a further continuation of the scientific search for differential diagnostic ultrasound criteria by leiomyomas and sarcomas of the uterus using modern technologies, including three-dimensional echography.

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