Endoplasmic reticulum stress mediates the arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells

Anticancer metal drugs and immunogenic cell death

“…This is surprising as multiple metal complexes including arsenic [78,79], iron [80], ruthenium [81], gold [82], copper [83][84][85], osmium [86], and iridium [87] compounds have been demonstrated to activate some hallmarks of ICD including ROS production and UPR as well as ER stress [59]. Thus we conclude that a systematic re-evaluation of promising experimental metal-containing anticancer compounds in an immunogenic environment is urgently needed.…”

“…In this context, CD47-blocking antibodies can also be considered potential factors to be used in ICD combinatorial strategies. Taking into account the broad involvement of ROS-mediated processes and ER stress in the mode-of-action of multiple experimental anticancer metal drugs mentioned above [64,78,79,[81][82][83][84][85][86][87], some of these compounds might also act as ICD adjuvants.…”

Modulation, functionality, and cytocompatibility of three-dimensional printing materials made from chitosan-based polysaccharide composites

“…The WS-1 cells were stained with fluorescein isothiocyanate (FITC)-labeled annexin-V/propidium iodide (PI) double strain, and the percentages of normal cells, apoptotic cells, and necrotic cells were calculated [34,35]. Fig.…”

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

“…The FF in EM patients may induce oxidative stress reaction in oocytes and cause DNA damage (45). In addition, AOPPs in the plasma induce endoplasmic reticulum stress in various cells (46)(47)(48)(49), and this stress has been observed to cause phenotypic alterations and death in cells (50,51). Under an environment with acute oxidative stress, the oocyte maturation is more likely to be arrested and the developmental potency of embryos is inevitably decreased.…”