Endopolyploidization and the interstitial invasion of the supergiant trophoblast cells of the field vole Microtus rossiaemeridionalis

Zybina, E V; Bogdanova, M S; Stein, G.I.; Vlasova, T. D.; Zybina, Tatiana G.

doi:10.1016/j.tice.2009.02.001

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…However, in some rodent giant trophoblast cells there occurs disintegration of the polytene chromosome bundles into numerous paired endochromosomes. It is the most strongly pronounced in the highly invasive supergiant trophoblast cells in the field vole placenta, which reach very high ploidy level 256c-16384c (Zybina et al, 2009). The degree of chromatid attachment in these cells is weakening, they detach one-by-one from the surface of the chromosome bundle.…”

Section: Transition From the Polytene Nucleus To The Polygenomic Onementioning

confidence: 98%

“…The level of ploidy clearly correlates with the ability of cells to invade endometrium, to lyse and to phagocytose partly its tissues in the course of embryo implantation. Beginning from the onset of differentiation, the primary and secondary giant trophoblast cells undergo a series of endoreduplication cycle reaching very high ploidy level -512c-1024c in rat and mouse (Zybina, Mosjan, 1967;Barlow, Sherman, 1972 ;Zybina, Zybina, 1996; 2048c and 16384c in the field vole (Zybina et al, 1975;Zybina et al, 2003;Zybina et al, 2009). The cells have the non-classical polytene chromosomes and can combine cell replication with the invasive and phagocytic activity (Zybina, Zybina, 2005).…”

Section: Cell Cycle Modification In Trophoblast Cell Of Mammalian Plamentioning

confidence: 99%

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Cell Cycle Modification in Trophoblast Cell Populations in the Course of Placenta Formation

Zybina¹,

Zybina²

2011

DNA Replication and Related Cellular Processes

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Section: Transition From the Polytene Nucleus To The Polygenomic Onementioning

confidence: 98%

Section: Cell Cycle Modification In Trophoblast Cell Of Mammalian Plamentioning

confidence: 99%

Cell Cycle Modification in Trophoblast Cell Populations in the Course of Placenta Formation

Zybina¹,

Zybina²

2011

DNA Replication and Related Cellular Processes

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“…Interestingly, the analogous population of invasive trophoblasts in mice is believed to undergo endoreduplication [33,34]. A few additional reports partly based on cytometry results suggested the possibility that human iCTBs have an elevated ploidy level (hypertetraploid and hyperoctaploid) [35][36][37].…”

Section: Pregnancymentioning

confidence: 99%

Somatic genomic variations in extra-embryonic tissues

Weier¹,

Ferlatte²,

Weier³

2010

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Abstract:In the mature chorion, one of the membranes that exist during pregnancy between the developing fetus and mother, human placental cells form highly specialized tissues composed of mesenchyme and floating or anchoring villi. Using fluorescence in situ hybridization, we found that human invasive cytotrophoblasts isolated from anchoring villi or the uterine wall had gained individual chromosomes; however, chromosome losses were detected infrequently. With chromosomes gained in what appeared to be a chromosomespecific manner, more than half of the invasive cytotrophoblasts in normal pregnancies were found to be hyperdiploid. Interestingly, the rates of hyperdiploid cells depended not only on gestational age, but were strongly associated with the extraembryonic compartment at the fetal-maternal interface from which they were isolated. Since hyperdiploid cells showed drastically reduced DNA replication as measured by bromodeoxyuridine incorporation, we conclude that aneuploidy is a part of the normal process of placentation potentially limiting the proliferative capabilities of invasive cytotrophoblasts. Thus, under the special circumstances of human reproduction, somatic genomic variations may exert a beneficial, anti-neoplastic effect on the organism.

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“…However, since the careful work of Orsini in the golden hamster ( Mesocricetus auratus ), it is widely accepted that the giant cells of the cricetid placenta and placental bed are trophoblastic in origin ( Orsini, 1954 ). Giant cells are polyploid due to endoduplication, a process that has been particularly well investigated in the East European grey vole [ Microtus mystacinus ( M. rossiaemeridionalis )] ( Zybina et al, 2005 ; Zybina et al, 2009 ; Zybina et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

The trophoblast giant cells of cricetid rodents

Favaron

Carter

2023

Front. Cell Dev. Biol.

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Giant cells are a prominent feature of placentation in cricetid rodents. Once thought to be maternal in origin, they are now known to be trophoblast giant cells (TGCs). The large size of cricetid TGCs and their nuclei reflects a high degree of polyploidy. While some TGCs are found at fixed locations, others migrate throughout the placenta and deep into the uterus where they sometimes survive postpartum. Herein, we review the distribution of TGCs in the placenta of cricetids, including our own data from the New World subfamily Sigmodontinae, and attempt a comparison between the TGCs of cricetid and murid rodents. In both families, parietal TGCs are found in the parietal yolk sac and as a layer between the junctional zone and decidua. In cricetids alone, large numbers of TGCs, likely from the same lineage, accumulate at the edge of the placental disk. Common to murids and cricetids is a haemotrichorial placental barrier where the maternal-facing layer consists of cytotrophoblasts characterized as sinusoidal TGCs. The maternal channels of the labyrinth are supplied by trophoblast-lined canals. Whereas in the mouse these are lined largely by canal TGCs, in cricetids canal TGCs are interspersed with syncytiotrophoblast. Transformation of the uterine spiral arteries occurs in both murids and cricetids and spiral artery TGCs line segments of the arteries that have lost their endothelium and smooth muscle. Since polyploidization of TGCs can amplify selective genomic regions required for specific functions, we argue that the TGCs of cricetids deserve further study and suggest avenues for future research.

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Endopolyploidization and the interstitial invasion of the supergiant trophoblast cells of the field vole Microtus rossiaemeridionalis

Cited by 5 publications

References 23 publications

Cell Cycle Modification in Trophoblast Cell Populations in the Course of Placenta Formation

Cell Cycle Modification in Trophoblast Cell Populations in the Course of Placenta Formation

Somatic genomic variations in extra-embryonic tissues

The trophoblast giant cells of cricetid rodents

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