Endoprosthetic Replacement for Giant Cell Tumour of the Proximal Femur

Khan, Shah Alam; Kumar, Ashok; Inna, Prashanth; Bakhshi, Sameer; Rastogi, Shishir

doi:10.1177/230949900901700306

Cited by 17 publications

(12 citation statements)

References 18 publications

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“…This finding corroborates the current literature, which shows that successful functional results can be achieved for most patients after implantation of a mega-prosthetic replacement of the proximal femur [18, 19]. The Kaplan–Meier analysis showed that the cumulative survival of the prostheses was generally longer than the cumulative survival of the patients.…”

Section: Discussionsupporting

confidence: 90%

Nicotine consumption may lead to aseptic loosening in proximal mega-prosthetic femoral replacement

et al. 2016

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BackgroundAseptic loosening after total hip arthroplasty is likely related to nicotine ingestion. However, aseptic loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and aseptic loosening rates after proximal mega-prosthetic femoral replacement.Materials and methodsA consecutive series of patients who received mega-prosthetic replacement of the proximal femur at our hospital between 2005 and 2015 were included. Their files were reviewed and evaluated for the influence of smoking on aseptic loosening rates. All living patients were invited to complete a functional follow-up assessment at our clinic.ResultsTwenty-six patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed aseptic loosening. Fisher’s exact test showed a relationship between nicotine consumption and aseptic loosening of the prostheses (p = 0.003).ConclusionsSmoking increases the likelihood of aseptic loosening after proximal mega-prosthetic femoral replacement.Level of evidenceLevel 4 according to Oxford Centre of Evidence-Based Medicine 2011.Electronic supplementary materialThe online version of this article (doi:10.1007/s10195-016-0426-7) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 90%

Nicotine consumption may lead to aseptic loosening in proximal mega-prosthetic femoral replacement

et al. 2016

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“…For these patients, tumor resection and prosthesis replacement can resolve the problem. Some studies have shown that after tumor-type prosthesis replacement, GCTB could be thoroughly treated, and the survival index was significantly improved, showing an adequate curative effect [29]. Therefore, the use of tumor type prosthesis replacement to treat GCTB has received much attention.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Recurrence of Giant Cell Tumor of Bone After Surgery: A Clinicopathological Study of 80 Cases from a Single Center

Cheng

Zhang

et al. 2015

Cell Physiol Biochem

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Background/Aims: This aim of the present study was to identify specific markers determining the recurrence of the giant cell tumor of bone (GCTB). Methods: This study involved the clinicopathological analysis of 80 cases. All of the clinical features, pathological fracture, Campanacci grade, histological features and surgical methods were reviewed. Immunohistochemistry was used to detect the expression of Ki-67, CD147, mutant p53 and p63 in GCTB. Comparisons between different groups were performed using the Chi-square test. The risk factors affecting recurrence were analyzed using a binary logistic model. Kaplan-Meier analysis was employed for the survival analysis between the groups. Cell proliferation assays, migration and invasion assays were used to detect the function of CD147 on GCTB in vitro. Results: The univariate analysis showed that Ki-67 and CD147 expression, pathological fracture, Campanacci grade and surgical method were associated with recurrence. The multivariate analysis revealed that CD147 expression, Campanacci grade and surgical method were the factors affecting GCTB recurrence. In addition, the Kaplan-Meier analysis revealed that these factors affected tumor-free survival time. In vitro study revealed that the CD147 knockdown by small interfering RNA (siRNA) technique dramatically reduced the proliferation, migration and invasion of GCTB. Conclusion: Our results suggest that CD147 may serve as an adequate marker for GCTB recurrence. Campanacci grade is a risk factor for GCTB recurrence, which is also affected by the surgical method used.

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“…Twenty‐seven of 28 studies reported functional outcomes. The Musculoskeletal Tumor Society (MSTS) system score was the most commonly utilized measure used to quantify function—reported in 26 studies . The range of mean MSTS system scores following limb salvage with TF, PF, DF, and PT megaprosthetics were 19 to 24, 21 to 28.3, 21.8 to 27.3, and 19.8 to 26, respectively.…”

Section: Resultsmentioning

confidence: 99%

Fitness, Function, and Exercise Training Responses after Limb Salvage With a Lower Limb Megaprosthesis: A Systematic Review

Wilson

Steadman

Beckman

et al. 2019

PM&R

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Objective: To describe the fitness, function, and exercise training responses of patients following reconstruction of the lower limb with a total femoral (TF), proximal femoral (PF), distal femoral (DF), or proximal tibial (PT) megaprosthesis. Type: Systematic review. Literature Survey: Five research databases were searched systematically for original studies published in English from 2006 to 2017 that reported fitness, functioning, or exercise training responses for one or more of the four types of lower limb megaprosthesis listed above.Methodology: Methodologic quality was assessed using a 22-item modified STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) checklist. Synthesis: Of the 5342 articles retrieved, 28 met the inclusion criteria. Thirteen studies reported fitness outcomes, primarily in PT, with none in TF. Impaired knee extensor strength of the affected limb was reported following limb salvage with PF, DF, and PT megaprosthetics. Impaired flexibility was reported following limb salvage with DF and PT megaprosthetics. Functional outcomes were described in all studies and were most commonly reported using the Musculoskeletal Tumor Society (MSTS) system score. Results indicated no clear difference in functional outcomes between megaprosthesis locations. No studies evaluated exercise training responses. Conclusions: This review identified impairments of lower limb strength and flexibility following limb salvage with a lower limb megaprosthesis. Similarity in functional outcomes for all four reported megaprosthetic locations may indicate a lack of sensitivity in outcome measures, including the absence of items assessing higher-level functioning. Exercise interventions that aim to improve fitness and function in this population have not been evaluated but are required given increasing 5-year survival rates. Level of Evidence: I

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Endoprosthetic Replacement for Giant Cell Tumour of the Proximal Femur

Abstract: Endoprosthetic replacement for Campanacci stage-III GCT of the proximal femur achieves good to excellent functional and oncological outcomes.

Cited by 17 publications

References 18 publications

Nicotine consumption may lead to aseptic loosening in proximal mega-prosthetic femoral replacement

Nicotine consumption may lead to aseptic loosening in proximal mega-prosthetic femoral replacement

Factors Affecting the Recurrence of Giant Cell Tumor of Bone After Surgery: A Clinicopathological Study of 80 Cases from a Single Center

Fitness, Function, and Exercise Training Responses after Limb Salvage With a Lower Limb Megaprosthesis: A Systematic Review

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