Endoscopic Endonasal Transsphenoidal Approach for Growth Hormone Secreting Pituitary Adenoma

Abstract

Background: The use of endoscopic endonasal trans-sphenoid surgery (EETS) as the first-line therapy for most pituitary adenomas is gaining popularity. Aim of the work: The primary goal of this research was to see how transsphenoidal endoscopic technique for a growth hormone-secreting pituitary adenoma affected hormonal reduction in relation to surgical excision extent. Patients and Methods: This prospective research was carried out at the Al Azhar University Hospitals' neurosurgery department (Al-Hussein and Bab El-Shaeria). This study was conducted on 15 cases with Growth hormone secreting pituitary adenoma that had undergone total or subtotal resection performed by endoscopic endonasal transsphenoidal surgery. Result: there was highly statistically substantial (p-value < 0.001) decreased post-operative growth hormone (3.4 ± 1.2) when compared with pre-operative growth hormone (38.1 ± 29.8). Highly statistically significant (p-value < 0.001) decreased post-operative IGF-1 (242.3 ± 102.1) when compared with pre-operative IGF-1 (665 ± 253). No statistically significant difference (p-value > 0.05) between pre-operative and post-operative the following hormones (ACTH, cortisol, T3, T4, TSH, testosterone, FSH, LH and PRL, estradiol). Conclusion:In individuals with acromegaly, the endoscopic endonasal transsphenoidal technique is an efficacious and secure treatment for adenomas. We discovered that using an endoscopic endonasal transsphenoidal technique reduced growth hormone and insulin-like growth factor-1 levels considerably.