Endoscopic eradication therapy for Barrett’s esophagus–related neoplasia: a final 10-year report from the UK National HALO Radiofrequency Ablation Registry

Wolfson, Paul; Ho, Kai Man Alexander; Wilson, Ash; McBain, Hazel; Hogan, Áine; Lipman, Gideon; Dunn, Jason M.; Haidry, Rehan; Novelli, Marco; Olivo, Alessandro; Lovat, Laurence

doi:10.1016/j.gie.2022.02.016

Cited by 24 publications

(21 citation statements)

References 35 publications

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“…Another potential source of bias is the fact that not all patients received an electronic diary after RFA (20 % for the hospital with most inclusions), either because they had no access to email or due to logistic constraints. However, the characteristics of age and sex in our patient cohort were comparable with other large prospective cohorts 16 17 . In addition, the most frequently used regimen for focal RFA in this study (3 × 12 J/cm 2 without cleaning) differs from the regimen in the instructions for use (2 × 12 J/cm 2 – clean – 2 × 12 J/cm 2 ).…”

Section: Discussionsupporting

confidence: 80%

The course of pain and dysphagia after radiofrequency ablation for Barrett’s esophagus-related neoplasia

et al. 2022

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Background Radiofrequency ablation (RFA) is effective for eradication of Barrett’s esophagus (BE) neoplasia, but little is known on the course of pain and dysphagia after RFA. We aimed to describe the course of post-RFA symptoms and to identify possible associated risk factors. Methods In this multicenter, observational cohort study, all RFA procedures registered in a prospective database were included. Patient and treatment characteristics were collected from medical records and patients self-registered post-procedural symptoms in electronic symptom diaries for 14 days. Mixed model regression was used for the analyses. Results In total, 255 diaries were completed. Post-RFA pain was reported for 95 % (95 %CI 93–98) of procedures (median duration 14 days; 25th–75th percentiles [p25–p75] 11–14) and major pain for 64 % (95 %CI 58–69; median duration 8 days, p25–p75 3–13). Post-procedural pain significantly increased with BE length, younger age, and no prior ablation. Dysphagia was present after 83 % (95 %CI 79–88) of procedures (median duration 13 days, p25–p75 9–14). The risk of dysphagia decreased with age and increased when patients experienced more pain. Conclusions RFA treatment for BE-related neoplasia seems a significant burden for patients, and post-procedural symptoms should be taken into account when counseling patients before starting endoscopic eradication therapy.

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Section: Discussionsupporting

confidence: 80%

The course of pain and dysphagia after radiofrequency ablation for Barrett’s esophagus-related neoplasia

et al. 2022

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“…Upper gastrointestinal endoscopy is still considered the standard method for the diagnosis of esophageal cancer [ 65 , 66 ]. Previous evidence shows that endoscopic techniques have made significant progress over the last decades [ 67 , 68 , 69 ]. WLI is widely used and the most basic endoscopy diagnostic modality to diagnose esophageal cancer [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Deep Learning for the Diagnosis of Esophageal Cancer in Endoscopic Images: A Systematic Review and Meta-Analysis

Islam

Poly

Walther

et al. 2022

Cancers

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Esophageal cancer, one of the most common cancers with a poor prognosis, is the sixth leading cause of cancer-related mortality worldwide. Early and accurate diagnosis of esophageal cancer, thus, plays a vital role in choosing the appropriate treatment plan for patients and increasing their survival rate. However, an accurate diagnosis of esophageal cancer requires substantial expertise and experience. Nowadays, the deep learning (DL) model for the diagnosis of esophageal cancer has shown promising performance. Therefore, we conducted an updated meta-analysis to determine the diagnostic accuracy of the DL model for the diagnosis of esophageal cancer. A search of PubMed, EMBASE, Scopus, and Web of Science, between 1 January 2012 and 1 August 2022, was conducted to identify potential studies evaluating the diagnostic performance of the DL model for esophageal cancer using endoscopic images. The study was performed in accordance with PRISMA guidelines. Two reviewers independently assessed potential studies for inclusion and extracted data from retrieved studies. Methodological quality was assessed by using the QUADAS-2 guidelines. The pooled accuracy, sensitivity, specificity, positive and negative predictive value, and the area under the receiver operating curve (AUROC) were calculated using a random effect model. A total of 28 potential studies involving a total of 703,006 images were included. The pooled accuracy, sensitivity, specificity, and positive and negative predictive value of DL for the diagnosis of esophageal cancer were 92.90%, 93.80%, 91.73%, 93.62%, and 91.97%, respectively. The pooled AUROC of DL for the diagnosis of esophageal cancer was 0.96. Furthermore, there was no publication bias among the studies. The findings of our study show that the DL model has great potential to accurately and quickly diagnose esophageal cancer. However, most studies developed their model using endoscopic data from the Asian population. Therefore, we recommend further validation through studies of other populations as well.

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“…The ability to achieve our immediate effectiveness goal of CE-IM has been demonstrated in randomized controlled trials and several large observational studies. 1,4,5 Although limited data have addressed the long-term goal of reduction in mortality related to EAC, 6,7 there is a growing body of evidence describing the durability of EET and variable risk of neoplastic recurrence after achieving CE-IM. [8][9][10][11][12][13] To address the potential risk of recurrent BE and BE-related neoplasia, endoscopic surveillance is recommended after CE-IM.…”

Section: Personalized Approach To the Post-endoscopic Eradication The...mentioning

confidence: 99%

Personalized Approach to the Post-Endoscopic Eradication Therapy Barrett’s Esophagus Patient

Wani

2022

Gastroenterology

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Endoscopic eradication therapy for Barrett’s esophagus–related neoplasia: a final 10-year report from the UK National HALO Radiofrequency Ablation Registry

Cited by 24 publications

References 35 publications

The course of pain and dysphagia after radiofrequency ablation for Barrett’s esophagus-related neoplasia

The course of pain and dysphagia after radiofrequency ablation for Barrett’s esophagus-related neoplasia

Deep Learning for the Diagnosis of Esophageal Cancer in Endoscopic Images: A Systematic Review and Meta-Analysis

Personalized Approach to the Post-Endoscopic Eradication Therapy Barrett’s Esophagus Patient

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