Endoscopic full-thickness resection and clip defect closure in the colon with the new FTRD system: experimental study

Schurr, M. O.; Baur, Franziska; Krautwald, Martina; Fehlker, Marion; Wehrmann, Manfred; Gottwald, Thomas; Prosst, Ruediger L.

doi:10.1007/s00464-014-3923-x

Cited by 48 publications

(31 citation statements)

References 16 publications

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“…Abb. 1) steht seit November 2014 dem Anwender offiziell zur Verfügung und ähnelt im Aufbau, Funktionsprinzip und der Handhabung dem Over-The-Scope-Clip [6,7]. Beide Verfahren basieren auf einem zirkulären Nitinol-Clip, der auf einer Applikationskappe sitzt, die auf das Gastro-oder Koloskop aufgesteckt wird.…”

Section: Full-thickness-resektion-deviceunclassified

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Full-Thickness-Resection-Device (FTRD)

Richter-Schrag

Walker

Thimme

et al. 2015

Chirurg

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The results show that FTRD is a safe and effective instrument for use in the lower gastrointestinal tract. Limitations of the FTRD system concerning full thickness resection are scarring, fibrosis and thickness of the intestinal wall, especially in the lower rectum; therefore, it is suggested that a simulation with a tube similar in size to the FTRD should be performed during the screening colonoscopy in order to establish whether an endoscopic resection with FTRD is possible.

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Section: Full-thickness-resektion-deviceunclassified

“…Flä-chen der tierexperimentell gewonnenen Resektate werden in der Literatur mit 3,3 bzw. 16 cm 2 [6,17] angegeben und erweisen sich mit einem mittleren Durchmesser von 2,4 cm bei Humanpräparaten mit entsprechender Pathologie als deutlich kleiner [14].…”

Section: Limits Und Komplikationenunclassified

Full-Thickness-Resection-Device (FTRD)

Richter-Schrag

Walker

Thimme

et al. 2015

Chirurg

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“…The size of the lesions is one of the major problems of the EFTR with the FTRD system, as they are limited by the size of the cap (length 23 mm, inner diameter 13 mm, allowing for a volume of up to 3 cm 3 ), lesions’ characteristics, and is strongly dependent on the rigidity of the colonic wall. While resection specimens of up to 54 mm have been reported in experiments with healthy porcine colon [17], all clinical series on EFTR with the FTRD support the removal of lesions with an estimated size of up to 30 mm. However, as has been previously reported, resection success decreased significantly for lesions > 20 mm.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Full-Thickness Resection of Colorectal Lesions with the New FTRD System: Single-Center Experience

de-Ferro¹,

Castela²,

Pereira³

et al. 2018

GE Port J Gastroenterol

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Background and Aims: Endoscopic full-thickness resection (EFTR) is an emerging technique for the treatment of various conditions for which classic endoscopic resection techniques have failed or were considered to be at high risk for perforation. The full-thickness resection device (FTRD) is an over-the-scope system which allows a single-step EFTR. The aim of our study is to describe our experience in EFTR of colorectal lesions using the FTRD. Methods: Nine patients (10 colorectal lesions) were proposed for EFTR. Safety, R0 resection and endoscopic treatment success were evaluated. Results: Reasons for referral included nonlifting adenomas (n = 4), nonlifting adenoma recurrence (n = 5), and submucosal lesion (n = 1). EFTR was technically successful in all patients. The mean duration of the procedure was 55 min. R0 resection was obtained in all patients. No major complications were detected. All lesions were successfully treated by the endoscopic technique and no patient was referred for surgery. In patients with available follow-up (n = 6), no recurrence was detected. Conclusions: EFTR is a feasible, reasonable time-consuming, safe, and promising endoscopic resection technique. Key Messages: FTRD is an additional tool for difficult-to-treat colorectal lesions.

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“…The FTRD system has been described in animals [45,46], and in a limited series of humans [73,74]. A prospective trial of the FTRD device in colonic lesions (difficult adenomas, early cancers, and subepithelial tumors) is currently recruiting participants (Clinicaltrials.gov id NCT02362126).…”

Section: Otsc and Eftr Integrated Devicementioning

confidence: 99%

“…In 2 subjects, more than one clip was required; one of these animals was sacrificed owing to lumen obstruction from the additional clip [44]. This prototype became the basis of a commercially available dedicated EFTR device based on the OTSC (FTRD, Ovesco), which has been tested in animal models of gastric subepithelial tumors [45] and colon EFTR [46].…”

Section: Ots Clipsmentioning

confidence: 99%