“…In the National Polyp Study [10], recur rence of adenomas was 32% after three years, and the only factor found to be associated with the detection of adeno mas with advanced pathological features was the number of adenomas at study entry. In a prospective study of large adenomas, mainly with a villous histology [68], a recur rence after polypectomy occurred in 28 % after a mean fol low-up of 1.4 years. In several follow-up studies of patients with colorectal adenomas, the recurrence rate for adeno mas was relatively low (6-33%) [23,40,69], but up to 59% after three years in a smaller study [70].…”