Endoscopic sentinel lymph node biopsy using indocyanine green‐neomannosyl human serum albumin

Park, Young Min; Yu, Quan; Kwon, Ki Hyeok; Cho, Jae-Gu; Woo, Jeong Soo; Kim, Beop Min; Lee, Yun Sang; Jeong, Jae Min; Kim, Hyun Koo; Song, Jae Jun

doi:10.1002/lary.27036

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…Organic nanocarriers for ICG are nature nanoparticles, such as serum albumin (albumin human, AH) [ 51 , 52 ]. ICG binding to albumin results in the improvement of its characteristic as a fluorescent marker — its fluorescent intensity increases.…”

Section: Theranostic Approachmentioning

confidence: 99%

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Papayan¹,

Akopov²

2021

Sovrem Tehnol Med

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The aim of the study was to assess the prospects for central lung cancer (CLC) screening using fluorescent diagnostics and its treatment by endobronchial photodynamic therapy (PDT).Bronchoscopic fluorescent diagnostics using chlorin e6 photosensitizers and a developed instrumental system enable to reveal tumor changes in large bronchi mucosa at early stages, and a developed PDT technique performed under fluorescent control helps achieve personalized treatment. Such an approach is considered as a theranostic technique -photodynamic theranostics.Central lung cancer screening requires a fluorescent dye characterized by availability and can be used directly within the examination. Indocyanine green can be used as a dye, its peculiarity is the necessity to excite and record fluorescence in the near-infrared (NIR) wavelength band. First experiments using NIR bands to diagnose a bronchoscopic system showed the detectability of tumor areas using on-site bronchoscopic photodynamic theranostics, which consists in NIR imaging of tumor foci when a standard dose of indocyanine green is administered during the examination.Conclusion. Further progress of early diagnostics and minimally invasive CLC therapy will be determined by the development of new photosensitizers, which should be characterized by a high absorption band in NIR area, quick accumulation in a tumor, high yield of single oxygen in NIR illumination, bright fluorescence, high potential in terms of the induction of an anti-tumor immune response.

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Section: Theranostic Approachmentioning

confidence: 99%

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Papayan¹,

Akopov²

2021

Sovrem Tehnol Med

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“…Previous preclinical studies have reported the superiority of MSA-ICG compared to ICG alone for SLN detection in porcine lung cancer model 40 , porcine esophageal cancer model 41 , and mouse tongue cancer model 42 . In these studies, CD206 was expressed at a high level in the macrophages of SLNs, and MSA-ICG exhibited a higher binding affinity to CD206 than ICG alone.…”

Section: Introductionmentioning

confidence: 99%

Detection of metastatic lymph node and sentinel lymph node mapping using mannose receptor targeting in in vivo mouse footpad tumor models and rabbit uterine cancer models

Jeong,

Jeon,

Hong

et al. 2024

International Journal of Surgery

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Background: This study aimed to evaluate the effectiveness of neo-mannosyl human serum albumin-indocyanine green (MSA-ICG) for detecting metastatic lymph node and mapping sentinel lymph node (SLN) using mouse footpad uterine tumor models. Additionally, we assessed the feasibility of MSA-ICG in SLN mapping in rabbit uterine cancer models. Materials and Methods: We compared the LN targeting ability of MSA-ICG with ICG. Six mouse footpad tumor models and two normal mice were each assigned to MSA-ICG and ICG, respectively. After the assigned tracers were injected, fluorescence images were taken, and we compared the signal-to-background ratio (SBR) of the tracers. A SLN biopsy was performed to confirm LN metastasis status and CD206 expression level. Finally, an intraoperative SLN biopsy was performed in rabbit uterine cancer models using MSA-ICG. Results: We detected 14 groin LNs out of 16 in the MSA-ICG and ICG groups. The SBR of the MSA-ICG group was significantly higher than that of the ICG group. The metastatic LN subgroup of MSA-ICG showed a significantly higher SBR than that of ICG. CD206 was expressed at a high level in metastatic LN, and the signal intensity difference increased as the CD206 expression level increased. SLN mapping was successfully performed in two of the three rabbit uterine cancer models. Conclusion: MSA-ICG was able to distinguish metastatic LN for an extended period due to its specific tumor-associated macrophage-targeting property. Therefore, it may be a more distinguishable tracer for identifying metastatic LNs and SLNs during uterine cancer surgery. Further research is needed to confirm these results.

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“…The utility of ICG is based on the properties of functional uptake in the lymph nodes via the lymphatics, radio-opacity on imaging and fluorescence when visualized at surgery. While the scope of literature regarding ICG use for management of head and neck cancer is small in comparison to other anatomic locations, one theme in initial studies is to investigate hybrid approaches in which ICG is combined with other contrast mechanisms such as 99 Tc [ 8 – 12 ]. Here, we investigate a new hybrid approach using ICG fluorescence combined with intraoperative cone-beam CT (CBCT) imaging.…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping using ICG fluorescence and cone beam CT – a feasibility study in a rabbit model of oral cancer

et al. 2020

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Background Current sentinel lymph node biopsy (SLNB) techniques, including use of radioisotopes, have disadvantages including the use of a radioactive tracer. Indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging and cone beam CT (CBCT) have advantages for intraoperative use. However, limited literature exists regarding their use in head and neck cancer SLNB. Methods This was a prospective, non-randomized study using a rabbit oral cavity VX2 squamous cell carcinoma model (n = 10) which develops lymph node metastasis. Pre-operatively, images were acquired by MicroCT. During surgery, CBCT and NIR fluorescence imaging of ICG was used to map and guide the SLNB resection. Results Intraoperative use of ICG to guide fluorescence resection resulted in identification of all lymph nodes identified by pre-operative CT. CBCT was useful for near real time intraoperative imaging and 3D reconstruction. Conclusions This pre-clinical study further demonstrates the technical feasibility, limitations and advantages of intraoperative NIR-guided ICG imaging for SLN identification as a complementary method during head and neck surgery.

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Endoscopic sentinel lymph node biopsy using indocyanine green‐neomannosyl human serum albumin

Abstract: NA. Laryngoscope, 128:E135-E140, 2018.

Cited by 10 publications

References 15 publications

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Detection of metastatic lymph node and sentinel lymph node mapping using mannose receptor targeting in in vivo mouse footpad tumor models and rabbit uterine cancer models

Sentinel lymph node mapping using ICG fluorescence and cone beam CT – a feasibility study in a rabbit model of oral cancer

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Endoscopic sentinel lymph node biopsy using indocyanine green‐neomannosyl human serum albumin

Abstract: NA. Laryngoscope, 128:E135-E140, 2018.

Cited by 10 publications

References 15 publications

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Detection of metastatic lymph node and sentinel lymph node mapping ​using mannose receptor targeting in in vivo mouse footpad tumor models and rabbit uterine cancer models

Sentinel lymph node mapping using ICG fluorescence and cone beam CT – a feasibility study in a rabbit model of oral cancer

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Detection of metastatic lymph node and sentinel lymph node mapping using mannose receptor targeting in in vivo mouse footpad tumor models and rabbit uterine cancer models