Endoscopic Submucosal Dissection is an Effective and Safe Therapy for Early Gastric Neoplasms

Sugimoto, Takafumi; Okamoto, Makoto; Mitsuno, Yuzo; Kondo, Shintaro; Ogura, Keiji; Ohmae, Tomoya; Mizuno, Hideo; Yoshida, Shuntaro; Isomura, Yoshihiro; Yamaji, Yutaka; Kawabe, Takao; Omata, Masao; Koike, Kazuhiko

doi:10.1097/mcg.0b013e31822f3988

Cited by 65 publications

(58 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumor size and resected specimen size were evaluated as risk factors in several studies. Lesion sizes > 10 mm 55 and >20 mm 43,56 were not found to increase PPB in some studies, whereas lesion sizes > 20 mm, 20,22,39,[57][58][59] >30 mm, 39 and >40 mm 58 were found to be associated with higher PPB risk in others. Regarding specimen size, the larger the ulcer, the higher the risk, with an artificial ulcer > 30 mm, 36 34 mm,…”

Section: Risk Factors For Ppbmentioning

confidence: 93%

“…29,33,34,62 Macroscopic type was also explored in several studies, with most finding no relation between morphology and PPB. 13,18,[20][21][22][23][24]28,29,32,34,39,42,43,61 However, flat, 58 depressed, 16 and flat/depressed 14,17 lesions were associated with increased PPB in some studies.…”

Section: Risk Factors For Post-esd Bleeding Risk Factormentioning

confidence: 99%

“…34 Furthermore, 10 studies found no significant differences in elderly patients, 19,25,30,[35][36][37][38][39][40][41] although 1 study identified age > 80 years as an independent risk factor for PPB. 42 PPB rates were similar between genders in most studies, [13][14][15][16][17][18][20][21][22][23][25][26][27][28][29][30][31][32][33][34]36,39,[42][43][44] with only 1 study reporting an association male sex associated with PPB. 24 Arterial hypertension was not identified as a risk factor in most studies, [13][14][15]17,18,[20][21][22][23][24][28]…”

Section: Risk Factors For Ppbmentioning

confidence: 99%

“…30,58 However, several studies reported no significant differences in PPB according to tumor location. [14][15][16][17][18][20][21][22][23][24][25][26][27][28][29]32,39,42,43,51,55,61 Horizontal localization (anterior or posterior wall; lesser or greater curvature) was not found to influence PPB in individual studies. [15][16][17][20][21][22][23][24]27,29 Regarding the relationship between…”

mentioning

confidence: 94%

See 3 more Smart Citations

Risk factors for bleeding after gastric endoscopic submucosal dissection: a systematic review and meta-analysis

Libânio

Costa

Pimentel‐Nunes

et al. 2016

Gastrointestinal Endoscopy

117

127

View full text Add to dashboard Cite

show abstract

Section: Risk Factors For Ppbmentioning

confidence: 93%

Section: Risk Factors For Post-esd Bleeding Risk Factormentioning

confidence: 99%

Section: Risk Factors For Ppbmentioning

confidence: 99%

mentioning

confidence: 94%

See 2 more Smart Citations

Risk factors for bleeding after gastric endoscopic submucosal dissection: a systematic review and meta-analysis

Libânio

Costa

Pimentel‐Nunes

et al. 2016

Gastrointestinal Endoscopy

117

127

View full text Add to dashboard Cite

show abstract

“…Bleeding during the procedure is very common but only rarely can be significant to the extent which requires the procedure to be stopped [21] . Compared to conventional EMR, the rate of perforation with ESD is higher, at about 1%-4% and it might require emergent surgical treatment but most of the time, perforations can be successfully managed conservatively [9,21,22] . In Japan, where there is a high incidence of the gastric cancer, a mass screening program with photofluorography, double-contrast radiography, chromoendoscopy, and endoscopy has been conducted since 1960 [23][24][25][26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

Training in endoscopic submucosal dissection

Coman

Gotoda²,

Draganov³

2013

WJGE

View full text Add to dashboard Cite

Endoscopic submucosal dissection (ESD) represents an important advancement in the therapy of early neoplastic gastrointestinal lesions by providing higher en-bloc curative resection rate with lower recurrence compared to endoscopic mucosal resection (EMR) and by sparing the involved organ and protecting patient' s quality of life. Despite these advantages ESD is associated with long procedure times and a higher rate of complications, making ESD a challenging procedure which requires advanced endoscopic skills. Thus, there has been a recognized need for structured training system for ESD to enhance trainee experience and, to reduce the risks of complications and inadequate treatment. ESD has a very flat learning curve. However, we do not have uniformly accepted benchmarks for competency. Nevertheless, it appears that, in Japan, more than 30 supervised gastric ESD procedures are required to achieve technical proficiency and minimize complications. A number of training algorithms have been proposed in Japan with the aim to standardize ESD training. These algorithms cannot be directly applied in the West due to substantial differences including the availability of highly qualified mentors, the type of pathology seen, choice of devices, and trainee's background. We propose a training algorithm for Western physicians which integrates both hands-on training courses, animal model work as well as visits to expert centers. No specific preceptor training programs have been yet developed but there is a consensus that these programs are important for permeation of ESD worldwide. Key words: Endoscopic submucosal dissection; Training; Learning curve; Early gastrointestinal cancer; Endoscopic mucosal resection Core tip: Endoscopic submucosal dissection (ESD) is a complex procedure associated with high complication rate. In Japan, training in ESD follows the traditional mentor/apprentice approach but significant variability in training approaches exists. We review the learning curves for ESD and describe the training algorithm proposed in Japan aiming to standardize training, and its applicability in the West. We highlight the challenges for ESD dissemination in the West, describing both the consensus and the diverging opinions between Asian and Western training models. Finally, we emphasize the need for structured training system to enhance trainee experience and, most importantly, to reduce the risks of complications and inadequate treatment.Coman RM, Gotoda T, Draganov PV. Training in endoscopic submucosal dissection. World J Gastrointest Endosc 2013; 5(8): 369-378 Available from:

show abstract

The Elevated ASK1 Expression Inhibits Proliferation and Invasion in Gastric Cancer HGC‐27 Cells

Wan

Shi

et al. 2018

The Anatomical Record

View full text Add to dashboard Cite

This study aimed to evaluate the effects and mechanism of action of ASK1 gene on the growth and migration of gastric cancer (GC) cells. Total RNA was extracted from the gastric cell lines and GC tissues. The expression level of ASK1, and the association between ASK1 expression and clinicopathological characteristics was assessed by real‐time polymerase chain reaction. The effects of ASK1 on the proliferation of HGC–27 cells were assessed by the CCK–8 assay. In addition, the effects of ASK1 on the migration of HGC–27 cells were analyzed by the migration assay using transwell chambers. The expression levels of signaling proteins related to cell migration were detected by Western blotting. Although no significant differences were observed in the expression levels of ASK1 between the GC tissue samples and the normal tissue samples (P = 0.241), ASK1 expression correlated with tumor lymph node metastasis (P = 0.008). Furthermore, ASK1 inhibited proliferation and migration of HGC–27 cells. The increase in the expression of ASK1 in HGC–27 cells induced the activation of the JNK and p38 signaling pathways. The findings demonstrated that increased ASK1 expression level inhibited migration and proliferation of HGC–27 gastric cancer cells, whereas the possible mechanism of action may be attributed to the activation of the JNK and p38 signaling pathways. Anat Rec, 301:1815–1819, 2018. © 2018 Wiley Periodicals, Inc.

show abstract

Endoscopic Submucosal Dissection is an Effective and Safe Therapy for Early Gastric Neoplasms

Cited by 65 publications

References 27 publications

Risk factors for bleeding after gastric endoscopic submucosal dissection: a systematic review and meta-analysis

Risk factors for bleeding after gastric endoscopic submucosal dissection: a systematic review and meta-analysis

Training in endoscopic submucosal dissection

The Elevated ASK1 Expression Inhibits Proliferation and Invasion in Gastric Cancer HGC‐27 Cells

Contact Info

Product

Resources

About