Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror

Abstract

A microelectromechanical system (MEMS) mirror based endoscopic swept-source optical coherence tomography (SS-OCT) system that can perform three-dimensional (3-D) imaging at high speed is reported. The key component enabling 3-D endoscopic imaging is a two-axis MEMS scanning mirror which has a 0.8×0.8 mm2 mirror plate and a 1.6×1.4 mm2 device footprint. The diameter of the endoscopic probe is only 3.5 mm. The imaging rate of the SS-OCT system is 50 frames/s. OCT images of both human suspicious oral leukoplakia tissue and normal buccal mucosa were taken in vivo and compared. The OCT imaging result agrees well with the histopathological analysis.

The potential role of in vivo optical coherence tomography for evaluating oral soft tissue: A systematic review

“…Eight of 27 articles described OCT images of different types of oral lesions. Tsai et al analyzed four groups of buccal mucosa samples: healthy mucosa, epithelial hyperplasia, moderate dysplasia, and squamous cell carcinoma of the oral cavity (OSCC), combining the results obtained using their handmade SS‐OCT system with histology.…”

“…Wang et al combined microelectromechanical systems (MEMSs) with SS‐OCT, creating a mirror‐based MEMS handmade endoscopic OCT. The OCT images of both human oral leucoplakia tissue and normal buccal mucosa were taken in vivo and compared with the histopathological analysis.…”

Correction of image distortions in endoscopic optical coherence tomography based on two-axis scanning MEMS mirrors

“…However, the reconstructed OCT images may be distorted. The diameter of the fabricated MEMS probe is 3.5mm [15]. The probe body is made of stainless steel for biocompatibility and robustness.…”

Miniature forward-viewing spectrally encoded endoscopic probe

“…Unlike other single fiber endoscope technologies, including distal mirror scanning [2,3], resonant fiber scanning [4], and endoscopic optical coherent tomography [5,6], SEE probes do not require rapid distal scanning, allowing for flexible submillimeter-diameter probes that do not contain moving parts. Interferometric SEE has been shown capable of 3D [7], subsurface [8], and Doppler [9] imaging with a high number of resolvable points and high signal-to-noise ratios (SNRs).…”