Endostatin as a novel prognostic biomarker in acute ischemic stroke

Zhang, Chenhuan; Qian, Sifan; Zhang, Rui; Guo, Daoxia; Wang, Aili; Peng, Yi; Peng, Hao; Li, Qunwei; Ju, Zhong; Geng, Deqin; Chen, Jing; Zhang, Yonghong; He, Jiang; Zhong, Chongke; Xu, Tan

doi:10.1016/j.atherosclerosis.2019.11.032

Cited by 16 publications

(13 citation statements)

References 35 publications

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“…ES is a highly effective and specific angiogenesis inhibitor. It mainly inhibits the proliferation of vascular endothelium in PCOS patients by promoting apoptosis of endothelial cells, thereby effectively inhibiting the formation of new blood vessels in PCOS patients [37]. Interesting, this present study has also found that the levels of β-trophin and ES in the IR group were higher than those in the non-IR group, suggesting that changes in serum β-trophin and ES levels are closely related to insulin resistance in patients with PCOS.…”

Section: Discussionsupporting

confidence: 72%

The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?

et al. 2021

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Background It’s necessary to investigate the serum β-trophin and endostatin (ES) level and its influencing factors in patients with newly diagnosed polycystic ovary syndrome (PCOS). Methods Newly diagnosed PCOS patients treated in our hospital were selected, and healthy women who took physical examination during the same period as healthy controls. We detected and compared the related serum indicators between two groups, Pearson correlation were conducted to identify the factors associated with β-trophin and ES, and the influencing factors of β-trophin and ES were analyzed by logistic regression. Results A total of 62 PCOS patients and 65 healthy controls were included. The BMI, WHI, LH, FSH, TT, FAI, FBG, FINS, HOMA-IR, TC, TG, LDL, ES in PCOS patients were significantly higher than that of healthy controls, while the SHBG and HDL in PCOS patients were significantly lower than that of healthy controls (all p < 0.05). β-trophin was closely associated with BMI (r = 0.427), WHR (r = 0.504), FBG (r = 0.385), TG (r = 0.405) and LDL (r = 0.302, all p < 0.05), and ES was closely associated with BMI (r = 0.358), WHR (r = 0.421), FBG (r = 0.343), TC (r = 0.319), TG (r = 0.404, all p < 0.05). TG, BMI, WHR and FBG were the main factors affecting the serum β-trophin levels (all p < 0.05). FBG, TC and BMI were the main factors affecting the serum ES levels (all p < 0.05). The TG, β-trophin, ES level in PCOS patients with insulin resistance (IR) were significantly higher than that of those without IR (all p < 0.05). Conclusion Increased β-trophin is closely associated with increased ES in patients with PCOS, which may be the useful indicators for the management of PCOS.

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Section: Discussionsupporting

confidence: 72%

The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?

et al. 2021

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“…As a consequence of BM degradation, biologically active matrikines might be liberated, which further propagate pathological effects [ 31 , 32 , 33 ]. In multiple cases, matrikines levels have been correlating with disease severity [ 34 , 35 ] and thus can serve as biomarkers [ 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Endothelial Basement Membrane Components and Their Products, Matrikines: Active Drivers of Pulmonary Hypertension?

Mutgan

Jandl

Kwapiszewska

2020

Cells

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Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling. Extracellular matrix (ECM) deposition in pulmonary arteries (PA) is one of the key features of vascular remodeling. Emerging evidence indicates that the basement membrane (BM), a specialized cluster of ECM proteins underlying the endothelium, may be actively involved in the progression of vascular remodeling. The BM and its steady turnover are pivotal for maintaining appropriate vascular functions. However, the pathologically elevated turnover of BM components leads to an increased release of biologically active short fragments, which are called matrikines. Both BM components and their matrikines can interfere with pivotal biological processes, such as survival, proliferation, adhesion, and migration and thus may actively contribute to endothelial dysfunction. Therefore, in this review, we summarize the emerging role of the BM and its matrikines on the vascular endothelium and further discuss its implications on lung vascular remodeling in pulmonary hypertension.

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“…Regarding outcome, it has been previously reported that tissue plasminogen activator (tPA)-treated stroke patients showing higher endostatin level at hospital admission had an impaired functional outcome three months after the event [34]. In relation to mortality, one study including 3463 acute ischemic stroke patients revealed that increased baseline endostatin levels were associated with increased risk of mortality and severe disability at 3 months [35]. However, to date, the association of endostatin and long-term mortality after stroke has not been explored.…”

Section: Discussionmentioning

confidence: 99%

Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke

Ramiro

Abraira

Quintana

et al. 2021

Life

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Stroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. Nine hundred and forty-one ischemic stroke patients were prospectively recruited in the Stroke-Chip study. Post-stroke mortality was evaluated during a median 4.8-year follow-up. A 14-biomarker panel was analyzed by immunoassays in blood samples obtained at hospital admission. Biomarkers were normalized and standardized using Z-scores. Multiple Cox regression models were used to identify clinical variables and biomarkers independently associated with long-term mortality and mortality due to stroke. In the multivariate analysis, the independent predictors of long-term mortality were age, female sex, hypertension, glycemia, and baseline National Institutes of Health Stroke Scale (NIHSS) score. Independent blood biomarkers predictive of long-term mortality were endostatin > quartile 2, tumor necrosis factor receptor-1 (TNF-R1) > quartile 2, and interleukin (IL)-6 > quartile 2. The risk of mortality when these three biomarkers were combined increased up to 69%. The addition of the biomarkers to clinical predictors improved the discrimination (integrative discriminative improvement (IDI) 0.022 (0.007–0.048), p < 0.001). Moreover, endostatin > quartile 3 was an independent predictor of mortality due to stroke. Altogether, endostatin, TNF-R1, and IL-6 circulating levels may aid in long-term mortality prediction after stroke.

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Endostatin as a novel prognostic biomarker in acute ischemic stroke

Cited by 16 publications

References 35 publications

The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?

The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?

Endothelial Basement Membrane Components and Their Products, Matrikines: Active Drivers of Pulmonary Hypertension?

Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke

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