1995
DOI: 10.1111/j.1365-2249.1995.tb03730.x
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Endothelial cell binding by human polyclonal anti-DNA antibodies: relationship to disease activity and endothelial functional alterations

Abstract: SUMMARY Polyclonal anti‐dsDNA and anti‐ssDNA antibodies (PoAb) that showed significant binding to human umbilical vein endothelial cells (HUVEC) were isolated from eight patients with systemic lupus erythematosus (SLE). Anti‐dsDNA PoAbs from five patients and anti‐ssDNA PoAbs from seven patients demonstrated enhanced binding to HUVEC during active disease, compared with PoAbs obtained from corresponding patients during remission. Reduction of the DNA content in the PoAb preparations by DNase treatment was asso… Show more

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Cited by 46 publications
(13 citation statements)
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“…In SLE, excessive endothelial activation has been observed in response to immune complexes, anti-endothelial cell antibodies, anti-dsDNA antibodies, cytokines (eg, TNFα) and anti-phospholipid antibodies 6 7 8 9 10. Well in line with these findings, we detected a positive correlation of Ang2 with IgG anti-dsDNA antibody titres and a negative correlation with C3 levels.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…In SLE, excessive endothelial activation has been observed in response to immune complexes, anti-endothelial cell antibodies, anti-dsDNA antibodies, cytokines (eg, TNFα) and anti-phospholipid antibodies 6 7 8 9 10. Well in line with these findings, we detected a positive correlation of Ang2 with IgG anti-dsDNA antibody titres and a negative correlation with C3 levels.…”
Section: Discussionsupporting
confidence: 87%
“…This process is associated with increased expression of luminal adhesion molecules (eg, vascular cell adhesion molecule 1 (VCAM-1)), leukocyte recruitment and disassembly of cell–cell junctions, finally resulting in loss of barrier function and tissue oedema 5. In SLE, several lines of evidence demonstrate excessive endothelial activation in response to immune complexes, anti-endothelial cell antibodies, anti-double-stranded DNA (dsDNA) antibodies, various cytokines (eg, tumour necrosis factor (TNF)α) and anti-phospholipid antibodies 6 7 8 9 10…”
mentioning
confidence: 99%
“…The cell binding activity of anti-dsDNA Abs is increased in active disease, vasculitis or lupus nephritis, suggesting that the binding of these Abs to target cells may be directly related to a pathogenic role [52][53][54]. In addition to cell binding properties, the cell-penetrating activities of autoantibodies are related to the function of the antibodies in the pathogenesis of the disease [4,13,14,[16][17][18][19][20].…”
Section: Discussionmentioning
confidence: 99%
“…ANXA2 is also strongly expressed in vascular tissue 12. Human anti-DNA antibodies can bind to endothelial cells 26. Moreover, anti-DNA antibodies activate endothelial and mesangial cells 3 27.…”
Section: Discussionmentioning
confidence: 99%