Endothelial cell dysfunction and preeclampsia

Wang, Peng-Hui; Yang, Ming-Jie; Chen, Chih-Yao; Chao, Hsiang‐Tai

doi:10.1016/j.jcma.2015.02.001

Cited by 16 publications

(7 citation statements)

References 10 publications

(14 reference statements)

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“…[ 15 ] In addition, these hypertensive disorders during pregnancy also increased the risk of placental abruption, small-for-gestational age (SGA) newborns, lower Apgar scores, and perinatal mortality. [ 18 – 20 ]…”

Section: Introductionmentioning

confidence: 99%

Avoiding excessive pregnancy weight gain to obtain better pregnancy outcomes in Taiwan

Horng

Huang²,

et al. 2018

Medicine

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Pregnancy weight gain may be associated with adverse pregnancy outcomes. The article aims to explore the relationship between weight change and pregnancy outcome in the Taiwanese pregnant women.The retrospective cohort study enrolled women with vertex singleton pregnancy at University-associated Hospital between 2011 and 2014. Pregnancy weight change was separated into 3 groups, based on the Institute of Medicine (IOM) guidelines: below (n = 221); within (n = 544); and above (n = 382). Analysis of variance, χ2 tests, generalized linear models, and logistic regression models were used for statistical comparisons.Pregnant women with weight change above IOM guidelines had a significant increase in both maternal and perinatal complications compared with normal controls (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.03–1.98; P = .043; OR 1.45, 95% CI 1.01–1.87; P = .049, respectively). This finding was not found in pregnant women with weight gain below IOM guidelines. Moreover, age (OR 1.08, 95% CI 1.02–1.15; P = .0011), pre-pregnancy weight (OR 1.04, 95% CI 1.01–1.09; P = .0008), pre-pregnancy body mass index (BMI; OR 1.15, 95% CI 1.06–1.30; P < .0001), weight at the time of delivery (OR 1.05, 95% CI 1.02–1.13; P < .0001) and BMI at the time of delivery (OR 1.15, 95% CI 1.06–1.39; P < .0001), all contributed to increased maternal complications but not perinatal complications, whereas parity (OR 0.23, 95% CI 0.12–0.41; P < .0001) and gestational age (OR 0.50, 95% CI 0.35–0.62; P < .001) were associated with fewer maternal complications.Our study reconfirmed that for Taiwanese pregnant women, the approximate pregnancy weight gain recommended by IOM in 2009 was associated with the fewest maternal and perinatal complications. If approximate pregnancy weight gain cannot be attained, even less weight gain during pregnancy is still reasonable without significantly and adversely affecting maternal and perinatal outcomes in Taiwan.

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Section: Introductionmentioning

confidence: 99%

Avoiding excessive pregnancy weight gain to obtain better pregnancy outcomes in Taiwan

Horng

Huang²,

et al. 2018

Medicine

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“…Increased levels of the placental pro-inflammatory cytokines, vasoconstrictors and lipid peroxidation products are known to be involved in the pathogenetic scenario of PE. An endothelial dysfunction is the central event in the end-organ failure [4][5][6] The systemic inflammatory response syndrome (SIRS) reflects the severity of PE but it mostly has no clinical equivalents in mild and moderate pre-eclamptic patients. 7 The SIRS accompanies severe PE or eclampsia and different types of shock.…”

Section: Introductionmentioning

confidence: 99%

Systemic Inflammatory Response Syndrome as a Reason for the Multiple Organ Failure in a Postpartum Preeclamptic Patient

Лахно¹

2018

Journal of South Asian Federation of Obstetrics and Gynaecology

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Background: The increased level of the placental proinflammatory cytokines, vasoconstrictors and lipid peroxidation products is known to be involved in the pathogenetic scenario of pre-eclampsia. Systemic inflammatory response syndrome captures the severity of pre-eclampsia (PE). The opinion about the possible role of infection in the origin and progression of pre-eclampsia is rather unpopular nowadays.Aim: To elucidate the involvement of the infectious agents in the pathogenesis of multiple organ failure syndrome in preeclampsia.Case report: An unusual case of the prodromal symptoms of eclampsia and systemic inflammatory response syndrome in the postpartum period associated with group B streptococcus infection was reported. But the resistant to the cephalosporins microbial flora was a reason for the progression severity of preeclampsia and puerperal sepsis. Since uterus was the source of sepsis the hysterectomy procedure has given a possibility to avoid general peritonitis and septic shock. Conclusion:The infectious inflammation could be involved in the pathogenesis of PE and contribute to the progressive severity of the disease.

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“…The theory most often discussed begins with endothelial damage which would stimulate the activity of platelets to perform adhesion, aggregation and release reaction [19] [20]. This event will end with decreasing levels of vasodilator substances such as prostacyclin and nitric oxide (NO), otherwise known as endothelium derived relaxing factor and increased vasoconstrictor substances such as thromboxane and endothelia [21].…”

mentioning

confidence: 99%

Correlation of Nitric Oxide (NO) and Corticotrophin Releasing Hormone (CRH) between Normal Pregnancy and Preeclampsia

Aziz¹,

Krisnadi²,

Effendi³

et al. 2016

OJOG

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Preeclampsia is still a major cause of maternal death in pregnancy which needs efforts to prevent and early detection. Nitric oxide and Corticotrophin Releasing Hormone has an important role in the pathogenesis of preeclampsia to determine differences in concentrations of NO and CRH in normal pregnancy and preeclampsia, as well as to study the correlation both on the incidence of preeclampsia. This is a cross sectional study. Blood samples obtained from patients with preeclampsia (30 samples) and normal pregnancies as controls (30 samples) in accordance with inclusion and exclusion criteria. NO concentration was examined with essay protocol, and CRH concentrations with ELISA method. Then be calculated by statistical analysis: chi square, t test, Mann-Whitney, and Spearman Rank correlation coefficient. Based on statistical analysis, there was no significant difference (p > 0.05) from the characteristics of maternal age, pregnancy weeks, and parity in both study groups, so the two groups of homogeneous and comparable. The mean concentration of NO in preeclampsia was lower (3.780 µM) compared with normal pregnancy (13.360 µM). There was significant correlation between NO and CRH concentrations in normal pregnancy and preeclampsia (p < 0.001). The involvement of NO/c-GMP pathway is very possible in the pathogenesis of preeclampsia.

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Endothelial cell dysfunction and preeclampsia

Cited by 16 publications

References 10 publications

Avoiding excessive pregnancy weight gain to obtain better pregnancy outcomes in Taiwan

Avoiding excessive pregnancy weight gain to obtain better pregnancy outcomes in Taiwan

Systemic Inflammatory Response Syndrome as a Reason for the Multiple Organ Failure in a Postpartum Preeclamptic Patient

Correlation of Nitric Oxide (NO) and Corticotrophin Releasing Hormone (CRH) between Normal Pregnancy and Preeclampsia

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