2011
DOI: 10.1101/cshperspect.a006429
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Endothelial Cell Heterogeneity

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Cited by 617 publications
(507 citation statements)
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References 70 publications
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“…55,56 An in vivo intact endothelium is exposed to multiple factors and is differentially regulated in space and time. 55,57 Current in vitro platforms for studying EC biology and permeability have limitations in incorporating these numerous and dynamic factors. Our BBV model cultures ECs under biomimetic flow conditions and we can expose cells to multiple external cues in a spatially and temporally controlled manner from the basal and/or apical side to understand their responses towards a heterogeneous environment.…”
Section: Resultsmentioning
confidence: 99%
“…55,56 An in vivo intact endothelium is exposed to multiple factors and is differentially regulated in space and time. 55,57 Current in vitro platforms for studying EC biology and permeability have limitations in incorporating these numerous and dynamic factors. Our BBV model cultures ECs under biomimetic flow conditions and we can expose cells to multiple external cues in a spatially and temporally controlled manner from the basal and/or apical side to understand their responses towards a heterogeneous environment.…”
Section: Resultsmentioning
confidence: 99%
“…Endothelial cells show considerable heterogeneity depending on vessel type and size, and the tissue bed in which they reside (Aird 2012). For example, endothelial cells in large vessels are joined by tight junctions and form a continuous layer, whereas capillary endothelium has gaps of varying sizes in different tissues.…”
Section: Endothelial Cellsmentioning
confidence: 99%
“…Endothelial cells regulate vascular tone and blood flow via synthesis of mediators such as nitric oxide (NO), whereas thrombosis is regulated both by synthesis of key proteins and by interaction with platelets. Endothelial cells also regulate inflammatory responses by modulating interactions of inflammatory cells with blood vessel walls (Sumpio et al 2002, Deanfield et al 2007, Aird 2012. Endothelial cells play a key role in new vessel formation by angiogenesis and vasculogenesis.…”
Section: Endothelial Cellsmentioning
confidence: 99%
“…4,5,23,24 However, permeability of endothelial cells under basal conditions and in response to edemagenic agents varies remarkably in different vascular beds. 2 Vascular beds of coronary, pulmonary, splenchnic, and skeletal muscle are composed of continuous nonfenestrated endothelial cells, which form a restrictive barrier.…”
Section: Endothelial Barrier Permeabilitymentioning
confidence: 99%