Endothelial cell injury induced by preservation solutions: a confocal microscopy study

Cellular Electrophysiological and Mechanical Effects of Celsior Solution on Endothelial Function in Resistance Coronary Arteries

“…Studies have reported that Celsior solution improved preservation of coronary endothelial function as demonstrated by significantly increased oxygenation ability, a lower PVR and a decreased wet/ dry ratio (6) and it could also improve the endothelial viability and proliferative capability of endothelial cells in cultured human greater saphenous vein (23). Further, endothelin and inducible NO synthase gene expression were detected significantly higher after cold storage in Celsior solution than in UW solution (24) although this effect was not compared to ST solution.…”

Cellular electrophysiologic and mechanical evidence of superior vascular protection in pulmonary microcirculation by Perfadex compared with Celsior

“…As reported, 9 compared with the low-potassium EC solution (containing 40 mmol/L of potassium), Celsior solution provides a significantly increased oxygenation ability, lower pulmonary vascular resistance, and decreased wet/ dry ratio during the lung preservation. Studies have reported that Celsior solution improved the endothelial viability and proliferative capability of endothelial cells in cultured human greater saphenous vein, 27 and that endothelin and inducible NO synthase gene expression were significantly higher after cold storage in Celsior solution compared with UW solution. 28 On the other hand, Celsior solution contains 15 mmol/L K þ that is still hyperkalemic, although the K þ concentration is relatively lower compared with UW or other hyperkalemic solutions.…”