Endothelial cell metabolism: A potential target to improve tumor immunity

Christensen, Julie Nelly; Wagman, Olivia; Kalucka, Joanna

doi:10.1016/j.coisb.2021.100376

Cited by 2 publications

(1 citation statement)

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“…Previous data have confirmed the regulatory role of mitochondria in angiogenesis via calcium homeostasis, heme synthesis, mitophagy, ROS production, and biogenesis of peroxisome proliferator‐activated receptor gamma coactivator‐1α (PGC‐1α), etc. (Christensen et al, 2021; Kluge et al, 2013). The loss of endothelial mitochondria homeostasis can abrogate the angiogenesis potential.…”

Section: Mitochondrial Activity and Angiogenesismentioning

confidence: 99%

Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle

Sadeghsoltani,

Hassanpour,

Safari

et al. 2024

Journal Cellular Physiology

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Angiogenesis is a complex process that involves the expansion of the pre‐existing vascular plexus to enhance oxygen and nutrient delivery and is stimulated by various factors, including hypoxia. Since the process of angiogenesis requires a lot of energy, mitochondria play an important role in regulating and promoting this phenomenon. Besides their roles as an oxidative metabolism base, mitochondria are potential bioenergetics organelles to maintain cellular homeostasis via sensing alteration in oxygen levels. Under hypoxic conditions, mitochondria can regulate angiogenesis through different factors. It has been indicated that unidirectional and bidirectional exchange of mitochondria or their related byproducts between the cells is orchestrated via different intercellular mechanisms such as tunneling nanotubes, extracellular vesicles, and gap junctions to maintain the cell homeostasis. Even though, the transfer of mitochondria is one possible mechanism by which cells can promote and regulate the process of angiogenesis under reperfusion/ischemia injury. Despite the existence of a close relationship between mitochondrial donation and angiogenic response in different cell types, the precise molecular mechanisms associated with this phenomenon remain unclear. Here, we aimed to highlight the possible role of mitochondria concerning angiogenesis, especially the role of mitochondrial transport and the possible relation of this transfer with autophagy, the housekeeping phenomenon of cells, and angiogenesis.

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Section: Mitochondrial Activity and Angiogenesismentioning

confidence: 99%