Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression

Kohlhaas, Johanna; Jäger, Marius Andreas; Lust, Leandra; Torre, Carolina De La; Hecker, Markus; Korff, Thomas

doi:10.1016/j.yexcr.2020.112446

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…Loss of enzymatic activity results in accumulation of the substrate 7-dehydrocholesterol, which increases vitamin D production. The inhibition of dehydrocholesterol reductase has been shown to decrease cholesterol biosynthesis in VSMCs, leading to impaired adhesion, migration, and proliferation, thereby affecting their functional steady state 40 . Given that the effect of cholesterol biosynthesis on VSMCs characteristics is largely unknown, the influence of miR-1204 on VSMCs in this context warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice

Liu,

Li,

Lin

et al. 2024

Nat Commun

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The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 participants were recruited for the screening of differentially expressed plasma microRNAs (miRNAs). We found that miR-1204 is significantly increased in both the plasma and aorta of elder patients with AAD and is positively correlated with age. Cell senescence induces the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induces vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. Furthermore, miR-1204 aggravates angiotensin II-induced AAD formation, and inhibition of miR-1204 attenuates β-aminopropionitrile monofumarate-induced AAD development in mice. Mechanistically, miR-1204 directly targets myosin light chain kinase (MYLK), leading to the acquisition of a senescence-associated secretory phenotype (SASP) by VSMCs and loss of their contractile phenotype. MYLK overexpression reverses miR-1204-induced VSMC senescence, SASP and contractile phenotypic changes, and the decrease of transforming growth factor-β signaling pathway. Our findings suggest that aging aggravates AAD via the miR-1204-MYLK signaling axis.

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Section: Discussionmentioning

confidence: 99%

Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice

Liu,

Li,

Lin

et al. 2024

Nat Commun

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“…Using RNA-seq, we found that the differentially expressed genes and lncRNAs between muscles from pasture-fed and barn-fed goats were mainly enriched in the cholesterol and triglyceride synthesis pathway. 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) [40] and 7-dehydrocholesterol reductase (DHCR7) are key steps in cholesterol synthesis [41], and a low-density lipoprotein (LDL) receptor is the main media mediation for the input of cholesterol [42]. Squalene synthase (SQS), encoded by FDFT1, is also a key regulator of cholesterol synthesis [43].…”

Section: Discussionmentioning

confidence: 99%

Novel Insights into the Differences in Nutrition Value, Gene Regulation and Network Organization between Muscles from Pasture-Fed and Barn-Fed Goats

Yang

Wang

Shan

et al. 2022

Foods

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The physiological and biochemical characters of muscles derived from pasture-fed or barn-fed black goats were detected, and RNA-seq was performed to reveal the underlying molecular mechanisms to identify how the pasture feeding affected the nutrition and flavor of the meat. We found that the branched chain amino acids, unsaturated fatty acids, and zinc in the muscle of pasture-fed goats were significantly higher than those in the barn-fed group, while the heavy metal elements, cholesterol, and low-density lipoprotein cholesterol were significantly lower. RNA-seq results showed that 1761 genes and 147 lncRNA transcripts were significantly differentially expressed between the pasture-fed and barn-fed group. Further analysis found that the differentially expressed genes were mainly enriched in the myogenesis and Glycerophospholipid metabolism pathway. A functional analysis of the lncRNA transcripts further highlighted the difference in fatty acid metabolism between the two feeding models. Our study provides novel insights into the gene regulation and network organization of muscles and could be potentially used for improving the quality of mutton.

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“…Therefore, the quality of cholesterol-related molecules may be a better clinical observation indicator. Additionally, although high serum cholesterol levels may lead to vascular inflammation and dysfunction of vascular endothelial cells, thereby affecting cerebral blood supply and influencing the development of AD, due to the independent nature of plasma cholesterol and brain cholesterol systems, cholesterol cannot cross the BBB to enter the brain, thus, plasma cholesterol may not be a good clinical observation indicator [ [67] , [68] , [69] , [70] , [71] ].…”

Section: Regulation Of Cholesterol Homeostasis In Admentioning

confidence: 99%

The Intersection of cerebral cholesterol metabolism and Alzheimer's disease: Mechanisms and therapeutic prospects

Liu,

Liang,

Liu

et al. 2024

Heliyon

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Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression

Cited by 10 publications

References 24 publications

Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice

Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice

Novel Insights into the Differences in Nutrition Value, Gene Regulation and Network Organization between Muscles from Pasture-Fed and Barn-Fed Goats

The Intersection of cerebral cholesterol metabolism and Alzheimer's disease: Mechanisms and therapeutic prospects

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