2014
DOI: 10.1089/scd.2014.0163
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Endothelial Cells Direct Mesenchymal Stem Cells Toward a Smooth Muscle Cell Fate

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Cited by 41 publications
(30 citation statements)
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“…26, 28 To examine the extent of this modulation by endothelial cells, we measured the expression of the microRNA gene cluster miR-143/145 , which has been linked to governing smooth muscle differentiation. 14, 16, 18 Coculture of human umbilical vein endothelial cells (HUVECs) with human aortic smooth muscle cells (HAoSMCs) caused an increase in precursor microRNA pri-miR-143/145 transcript as well as the individual mature microRNAs (Figure 1A–C).…”
Section: Resultsmentioning
confidence: 99%
“…26, 28 To examine the extent of this modulation by endothelial cells, we measured the expression of the microRNA gene cluster miR-143/145 , which has been linked to governing smooth muscle differentiation. 14, 16, 18 Coculture of human umbilical vein endothelial cells (HUVECs) with human aortic smooth muscle cells (HAoSMCs) caused an increase in precursor microRNA pri-miR-143/145 transcript as well as the individual mature microRNAs (Figure 1A–C).…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, ECs can drive MSCs toward a smooth muscle lineage. A recent report from Lin and Lilly [2014] showed that in coculture ECs induced SMC differentiation in MSCs. ECs can promote a contractile phenotype, reduce proliferation, and enhance collagen synthesis and secretion.…”
Section: Application In Tebvsmentioning
confidence: 99%
“…Source MSCs are multipotent stromal cells with the ability to self-renew and differentiate into a variety of cell types, including osteoblasts, chondrocytes, ECs, SMCs and adipocytes [Beyer Nardi and da Silva Meirelles, 2006;Cui et al, 2012;Lin and Lue, 2013;Lin and Lilly, 2014]. They have the potential be used allogenically to improve the outcomes of damaged tissue repair due to their anti-inflammatory, antifibrotic, antimicrobial, and regenerative properties, and lack of major histocompatibility complex (MHC) II [Park et al, 2007;Sutton and Bonfield, 2014].…”
Section: Mesenchymal Stem Cellsmentioning
confidence: 99%
“…In vitro, activation of the Notch pathway and subsequent differentiation of SMC precursors can be achieved with exogenous introduction or overexpression of Jag1 or NICD [126,129]. VSMC differentiation studies have also activated the Notch pathway with coculture of EC or other cells that express Notch ligands [127,132].…”
Section: Cell-cell Contact Signalingmentioning
confidence: 99%