Endothelial cells in the context of brain arteriovenous malformations

Sammons, Vanessa; Davidson, Andrew; Tu, Jian; Stoodley, Marcus A.

doi:10.1016/j.jocn.2010.04.045

Cited by 25 publications

(22 citation statements)

References 47 publications

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“…Integrin aVb3 has increased expression in cerebral AVMs. 16,33,43 Endoglin (ENG) is a glycoprotein located on cellular surfaces crucial for angiogenesis. High levels of endoglin enhance the effects of ACVRL1 over endothelial proliferation.…”

Section: Avm Formationmentioning

confidence: 99%

“…Angiogenic factors, like VEGF, are not normally produced by quiescent brain vasculature, but are by AVM-BECs. 43 In contrast to mature vessels, immature vessels are associated with a fibronectin-rich matrix deficient in laminin. The high concentration of laminin and the absence of fibronectin in AVM vessels favor the hypothesis that they are relatively mature vessels.…”

Section: Avm Growth and Rupturementioning

confidence: 99%

“…15,22,36,41 Given that the large majority of high-grade lesions cannot be treated without relatively high morbidity and mortality using current surgical and radiosurgical paradigms, new cellular and molecular biological therapies are under development aiming toward radiosensitization, vascular targeting, and remodeling therapies. 27,43 The current AVM treatment paradigm does not take into consideration any special factors related to the genetics or molecular constitution of the specific patient who has an AVM. It is reasonable to think at some point that a better understanding of regulatory factors and pathways may allow us to modify the natural history away from rupture.…”

Section: Current Managementmentioning

confidence: 99%

“…11,58 The effect of radiation on the molecular process of AVM pathophysiology is of particular interest given its known ability, delivered as SRS, to drive endothelial proliferation and ultimately AVM obliteration. 43 Radiation elevates proapoptotic factors, such as p53, p21Waf-1, and mdm-2 mRNA. Elevation of TGF-b and a-smooth muscle actin generates fibroblast transformation into myofibroblasts, possibly leading to shrinkage and obliteration of cerebral AVMs.…”

Section: 58mentioning

confidence: 99%

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Molecular and cellular biology of cerebral arteriovenous malformations: a review of current concepts and future trends in treatment

Rangel-Castilla¹,

Russin²,

Martinez-del-Campo³

et al. 2014

FOC

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Object Arteriovenous malformations (AVMs) are classically described as congenital static lesions. However, in addition to rupturing, AVMs can undergo growth, remodeling, and regression. These phenomena are directly related to cellular, molecular, and physiological processes. Understanding these relationships is essential to direct future diagnostic and therapeutic strategies. The authors performed a search of the contemporary literature to review current information regarding the molecular and cellular biology of AVMs and how this biology will impact their potential future management. Methods A PubMed search was performed using the key words “genetic,” “molecular,” “brain,” “cerebral,” “arteriovenous,” “malformation,” “rupture,” “management,” “embolization,” and “radiosurgery.” Only English-language papers were considered. The reference lists of all papers selected for full-text assessment were reviewed. Results Current concepts in genetic polymorphisms, growth factors, angiopoietins, apoptosis, endothelial cells, pathophysiology, clinical syndromes, medical treatment (including tetracycline and microRNA-18a), radiation therapy, endovascular embolization, and surgical treatment as they apply to AVMs are discussed. Conclusions Understanding the complex cellular biology, physiology, hemodynamics, and flow-related phenomena of AVMs is critical for defining and predicting their behavior, developing novel drug treatments, and improving endovascular and surgical therapies.

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Section: Avm Formationmentioning

confidence: 99%

Section: Avm Growth and Rupturementioning

confidence: 99%

Section: Current Managementmentioning

confidence: 99%

Section: 58mentioning

confidence: 99%

See 2 more Smart Citations

Molecular and cellular biology of cerebral arteriovenous malformations: a review of current concepts and future trends in treatment

Rangel-Castilla¹,

Russin²,

Martinez-del-Campo³

et al. 2014

FOC

View full text Add to dashboard Cite

show abstract

“…Abnormal angiogenesis has an important role in bAVM genesis and evolution4 and VEGF, in particular, has been shown to interfere at many levels of bAVM formation and evolution 3 4. VEGF is not produced by quiescent brain but it is found in AVMs brain endothelial cells22 and it is highly expressed in children with recurrent AVMs 5. An increase in VEGF receptors has been noticed in syndromic and sporadic bAVM 5.…”

Section: Discussionmentioning

confidence: 99%