Endothelial dysfunction, ADMA and insulin resistance in essential hypertension

Perticone, Francesco; Sciacqua, Angela; Maio, Raffaele; Perticone, Maria; Leone, Giulia; Bruni, Rosamaria; Cello, Serena Di; Pascale, Alessandra; Talarico, Giusy; Greco, Luigi; Andreozzi, Francesco; Sesti, Giorgio

doi:10.1016/j.ijcard.2008.12.131

Cited by 74 publications

(76 citation statements)

References 33 publications

(40 reference statements)

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“…80,81 In contrast, in women with gestational diabetes increased plasma ADMA levels were not associated with insulin resistance. 82 This discrepancy might be explained by the fact that ADMA is directly associated with blood glucose levels, 81,83 so that the association of ADMA and insulin resistance state may be modified in diabetes versus pre-diabetes. Table 1 gives an overview of published clinical studies on ADMA in diabetes mellitus and insulin resistance.…”

Section: Adma and Diabetes Mellitusmentioning

confidence: 99%

“…Perticone et al 83 -63 hypertensive subjects -21 normotensive healthy subjects -ADMA and L-arginine were strongly associated with HOMA index (IS) in hypertensive patients, but not in normotensive patients -ADMA was an independent predictor of FBF und HOMA in the hypertensive group -HOMA was the only independent predictor of ADMA in the hypertensive group preserving DDAH activity. 107 An acute reduction of ADMA plasma levels by insulin was also demonstrated in 15 young patients with type 1 diabetes mellitus.…”

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confidence: 98%

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Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

Anderssohn

Schwedhelm

Lüneburg

et al. 2010

Diabetes and Vascular Disease Research

114

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Asymmetric dimethylarginine (ADMA) has evolved as an important regulator of nitric oxide (NO) synthesis in recent years. Elevated levels of ADMA have been reported in many conditions associated with a high cardiovascular risk. Moreover, ADMA is a biomarker for major cardiovascular events and mortality in cohorts with high, intermediate and low overall cardiovascular risk. Discrepant data have been reported on cardiovascular risk in people with and without diabetes mellitus, and the association of ADMA with diabetes mellitus per se has also remained controversial, possibly relating to type and stage of diabetes. Clinical and experimental data suggest that there is a multifaceted link between ADMA and insulin metabolism and action on one hand, and ADMA and glucose utilisation on the other. This interplay may be regulated by the enzyme involved in the metabolic degradation of ADMA, dimethylarginine dimethylaminohydrolase (DDAH). Recent data from prospective clinical studies suggest that whilst ADMA may be a marker for total mortality in patients without diabetes, elevated ADMA may exert beneficial effects in patients with diabetes. In this respect, ADMA could serve as a re-coupling agent overcoming endothelial nitric oxide synthase (eNOS) uncoupling in patients with diabetes. Anticipated advances in clinical and experimental investigation will help us to better understand this complex interrelationship between diabetes, eNOS, DDAH and ADMA.

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Section: Adma and Diabetes Mellitusmentioning

confidence: 99%

mentioning

confidence: 98%

Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

Anderssohn

Schwedhelm

Lüneburg

et al. 2010

Diabetes and Vascular Disease Research

114

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“…26 hsCRP seviyelerinin de diğer faktörlerden bağımsız olarak hipertansif hastalarda yükseldiği gösterilmiştir. [27][28][29] Çalışmamızda hsCRP ve Lp(a) değerleri evre 2 hipertansiyonlu grupta anlamlı olarak daha yüksek bulundu. Tüm hasta grubunda inflamasyon parametreleri yüksek olan hastaların fonksiyonel olarak KVS değişikliklerinin diğer gruba göre daha fazla olduğu saptandı.…”

Section: Discussionunclassified

Is the Childhood Primary Hypertension Causes Target Organ Damage?

Şahan¹,

Sözeri²,

Devecí³

et al. 2016

Turkiye Klinikleri J Pediatr

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Ö ÖZ ZE ET T A Am ma aç ç: : Çocukluk çağında primer hipertansiyonun yüksek kardiyovasküler mortalite ve morbidite ile ilişkisi son yıllarda ciddi bir sağlık sorunu hâline gelmiş ve giderek önem kazanmıştır. Bu çalışmada, primer hipertansiyonlu çocuklarda geleneksel ve geleneksel olmayan risk faktörleri ve bu faktörlerin hedef organ hasarı üzerine etkisinin araştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Primer hipertansiyon tanısı alan 7-18 yaş arasındaki 50 hasta ile aynı yaş grubunda sağlıklı 100 kişi kontrol grubu olarak çalışmaya alındı. Hasta grubuna 24 saatlik yaşam içi kan basıncı ölçümü yapıldı. Biyokimyasal olarak kan lipitleri, hs CRP, Lp(a) bakıldı. Hedef organ tutulumu açısından retinopati, nefropati (24 saatlik idrarda mikroalbuminüri), kardiyopati (sol ventrikül hipertrofisi ve sol ventrikül kitle indeks) ve vaskülopati (karotis intima mediya kalın-lığı ve arteriyel katılık) değerlendirildi. B Bu ul lg gu ul la ar r: : Toplam 50 (35 erkek, 15 kız) hastada ortalama yaş 13,1±3,2 yıl, 100 (54 erkek, 46 kız) sağlıklı kontrolde 13,06±2,7 yıl idi. Hastaların 17 (%34)'sinde göz dibi etkilenmesi mevcuttu (14 (%28)'ünde evre 1, 3 (%6)'ünde evre 2 hipertansif retinopati). Bir (%2) hastada ekokardiyografik olarak sol ventrikül hipertrofisi görüldü. Sol ventrikül kitle indeksi 7 (%14) hastada yüksek saptandı (Ort: 28,32±11,43 g/m2,7). 26 (%52) hastada cIMT (sağda 0,468±0,062, solda 0,472±0,064 mm, kontrol grubunda sağda 0,406±0,041, solda 0,405±0,041; p=0,000), 18 (%36) hastada PWV (5,76±0,84 m/s, kontrol grubunda 5,30±0,70 m/s; p=0,000), 11 (%22) hastada santral augmentasyon indeksi (%10,54±6,56, kontrol grubunda %9,41±8,54; p=0,366) yüksek bulundu. Hastalığın şiddeti arttıkça mikroalbuminüri ve inflamasyon göstergelerinin anlamlı olarak arttığı, HDL değerlerinin düştüğü görüldü. Beyaz önlük hipertansiyonu saptanan 8 hastada değişik derecelerde hedef organ tutulumu saptandı. S So on nu uç ç: : Çocukluk çağında primer hipertansiyon, hedef organ hasarı yapması nedeni ile erken tanınması ve tedavi edilmesi gereken bir durumdur.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Hipertansiyon; organ; çocuk A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The primary hypertension in childhood that is related with high cardiovascular morbidity and mortality has been a serious health problem in recent years and has become more important. In this study, the exploration of the effects of traditional and nontraditional risk factors over target organ damage in children with primary hypertension is aimed. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 50 patients who are between 7-18 years old and diagnosed as primary hypertension and 100 healthy children in the same age as a control group were evauated in study. Ambulatory blood pressure measurement within 24 hours was performed to the patient group. Biochemically, blood lipids, hs CRP, Lp(a) were measured. In terms of target organ involvement, retinopathy, nephropathy (microalbuminuria in 24-hour urine), car...

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“…Recent studies offer solid support to the concept that albuminuria is a marker of endothelial dysfunction in the heart and kidneys (7)(8)(9)(10).…”

Section: Diabetic Micro and Macrovascular Complications Are Well Idenmentioning

confidence: 90%

The Assessment of Pulmonary Diffusing Capacity in Diabetes Mellitus with Regard to Microalbuminuria

et al. 2009

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Endothelial dysfunction, ADMA and insulin resistance in essential hypertension

Cited by 74 publications

References 33 publications

Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

Is the Childhood Primary Hypertension Causes Target Organ Damage?

The Assessment of Pulmonary Diffusing Capacity in Diabetes Mellitus with Regard to Microalbuminuria

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