2017
DOI: 10.1111/bjd.15576
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Endothelial dysfunction and mechanobiology in pathological cutaneous scarring: lessons learned from soft tissue fibrosis

Abstract: Hypertrophic scars/keloids are pathogenic scars that are characterized by collagen and fibroblast accumulation. The endothelia in the lesions are mechanosensitive and participate actively in the pathogenesis of these scars. The present review summarizes how endothelium responds to mechanical stimuli such as shear, stretch and hydrostatic pressure. It also shows that in heart, liver, kidney and lung fibrosis, endothelial dysfunctions (EDs) associate with changes in vascular tone, endothelial permeability, coagu… Show more

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Cited by 33 publications
(44 citation statements)
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“…This impairment arises partly from chronic exposure to low-level biomechanical stimuli such as shear, stretch, and hydrostatic pressure that eventually changes vascular tone, vascular permeability, and coagulation and vasomodulation activity. These stimuli and their effects on endothelial cells induce a vicious self-perpetuating cycle of inflammation, hypertension, microthrombosis, and endothelial cell hypersensitivity to these biomechanical stimuli [7].…”
Section: Endothelial Dysfunctionmentioning
confidence: 99%
See 1 more Smart Citation
“…This impairment arises partly from chronic exposure to low-level biomechanical stimuli such as shear, stretch, and hydrostatic pressure that eventually changes vascular tone, vascular permeability, and coagulation and vasomodulation activity. These stimuli and their effects on endothelial cells induce a vicious self-perpetuating cycle of inflammation, hypertension, microthrombosis, and endothelial cell hypersensitivity to these biomechanical stimuli [7].…”
Section: Endothelial Dysfunctionmentioning
confidence: 99%
“…Moreover, treatment with antihypertension pharmaceuticals such as angiotension-converting enzyme inhibitors (e.g., captopril and enalapril) can improve keloids [6]. Third, as shown by a comprehensive review of the studies in the field, there are multiple lines of evidence that suggest endothelial dysfunction plays a crucial role in scar pathophysiology [7].…”
Section: Introductionmentioning
confidence: 99%
“…These phenomena are well described in dermal wounds 5 and internal organs, like the lung and liver 610 , where recurrent inflammation may lead to chronic fibrosis and deterioration of function. In organ fibrosis, various anti-fibrotic drugs have shown clinical promise in reducing the formation of scars and halting, or at least slowing the progression of, functional loss 11 .…”
Section: Introductionmentioning
confidence: 99%
“…Within the classic wound healing response, tissue injury results in cell proliferation, differentiation, extracellular matrix production and remodeling; alterations in this process can lead to uncontrolled deposition of granulation tissue, fibrosis, and scar formation. These phenomena are well described in dermal wounds 5 and internal organs, like the lung and liver, [6][7][8][9][10] where recurrent inflammation may lead to chronic fibrosis and deterioration of function. In organ fibrosis, various anti-fibrotic drugs have shown clinical promise in reducing the formation of scars and halting, or at least slowing the progression of, functional loss.…”
mentioning
confidence: 99%
“…ECs are the main component of the vascular system and play crucial roles in the modulation of vascular tone, leukocyte adhesion, migration and angiogenesis . In this issue of the BJD , Huang and colleagues reviewed the role of endothelial cells in pathological cutaneous scarring . In normal wound healing, ECs not only participate in all four phases of wound healing (i.e.…”
mentioning
confidence: 99%