Endothelial Dysfunction in Children with Steroid-Resistant Nephrotic Syndrome

Kari, Jameela A.; Quinlan, Catherine; Deanfield, John; Shroff, Rukshana; Tullus, Kjell

doi:10.5812/ijp.8026

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Correspondingly, Mehta et al [26] in their study, conducted on 66 children with NS and 128 age and sex matched healthy controls, found that CIMT was signi cantly higher in NS especially in the age above 4 years. In consonance with our study, Kari et al [27] reported higher CIMT in children with SRNS than the controls. However, unlike our results, Kniazewska et al [10] didn't nd signi cant differences in CIMT between 30 children previously treated for nephrotic syndrome versus 30 healthy children as a control group.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome

Kamel

AlGhawass

Sayed

et al. 2022

Preprint

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Background: Nephrotic syndrome is the one of the commonest renal disorders in children. Children with nephrotic syndrome (NS) are at a high risk of atherosclerosis due to hyperlipidemia, hypertension. Carotid intima media thickness (CIMT) is a surrogate marker for atherosclerosis. This study aimed to evaluate the carotid intima media thickness in children with nephrotic syndrome and its relation to different risk factors. Methods: This is an observational case control study that included forty children with nephrotic syndrome and thirty healthy children as controls. The inclusion criteria were: age of 2 years or more with disease duration of minimum of 1 year and glomerular filtration rate >90mL/min/1.73m2. CIMT was assessed by ultrasound. Lipid profile, protein/creatinine ratio in urine and kidney function tests were done. Results: The mean CIMT (mm) was significantly higher in patients with NS (0.477± 0.04) compared to controls (0.39± 0.03) (P <0.001) even when compared across different age groups. 60% of patients had received non-steroid immunosuppressive therapy. CIMT was significantly higher in patients receiving non-steroid immunosuppressive therapy than those receiving steroids alone. Subsequently, CIMT had significant positive correlation to duration of the disease (p= 0.05), body mass index (BMI) (p=0.03), number of relapses (p=0.01) and diastolic blood pressures (p=0.003). Conclusion: Children with NS had significantly higher CIMT than control group. CIMT was positively correlated to disease duration, number of relapses and BMI. It was significantly higher among patients receiving non-steroid immunosuppressive therapy than those receiving steroids alone.

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Section: Discussionsupporting

confidence: 93%

Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome

Kamel

AlGhawass

Sayed

et al. 2022

Preprint

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“…Here, derivatives of nitrogen mustard, such as chlorambucil, which is considered a cost-effective therapy, and combined treatment with steroids can prevent clinical SRNS patients from prolonged heavy proteinuria and potential complications. However, the data addressing the independent evaluation of CHL treatment has been poorly reported in the literature [20,21]. For this reason, our study aims to evaluate the equivalent efficiency between affordable CHL treatment and relatively expensive TAC treatment.…”

Section: Introductionmentioning

confidence: 99%

Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome

Yang

Zhao

Xiao

et al. 2018

Kidney Blood Press Res

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Background/Aims: The present study aimed to explore the equivalence of CHL and tacrolimus (TAC), despite reports regarding the efficacy and safety of TAC in treating SRNS patients. Methods: A retrospective cohort study of CHL or TAC treatment was performed by collecting the medical records of SRNS patients with a pathological classification of focal segmental glomurular sclerosis (FSGS) or membranous nephropathy (MN) from December 2008 to December 2014 in a 3A grade hospital in southern China. The treatment regimen includes 6 months of induction therapy and a subsequent 6 to 30 months of maintenance therapy, which were evaluated by the scheduled follow-up and the detection of proteinuria and serum creatinine levels. The treatment outcomes were classified as complete remission, partial remission or no remission. Results: In a total of 146 SRNS patients, CHL treatment showed a higher proportion of complete remission (27.8% vs 14.9%) or partial remission (52.8% vs 37.8%) compared to TAC treatment (P < 0.10) at the stage of induction therapy. The CHL treatment of SRNS patients with FSGS showed better efficacy than treatment of the TAC group, but the difference of efficacy in the pathological type of MN between CHL and TAC group was not significant (P > 0.10). During maintenance therapy, the difference between the CHL and TAC groups was not significant in the SRNS patients with FSGS or MN (P > 0.10). In addition, the difference of adverse effects between CHL and TAC group was not significant (P > 0.10), although there was a slightly higher proportion of nausea and vomiting in the CHL group. Conclusion:

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Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome

et al. 2022

View full text Add to dashboard Cite

Background Nephrotic syndrome is the one of the commonest renal disorders in children. Children with nephrotic syndrome (NS) are at a high risk of atherosclerosis due to hyperlipidemia, hypertension. Carotid intima media thickness (CIMT) is a surrogate marker for atherosclerosis. This study aimed to evaluate the carotid intima media thickness in children with nephrotic syndrome and its relation to different risk factors. Methods This is an observational case control study that included forty children with nephrotic syndrome and thirty healthy children as controls. The inclusion criteria were: age of 2 years or more with disease duration of minimum of 1 year and glomerular filtration rate > 90 mL/min/1.73m2. CIMT was assessed by ultrasound. Lipid profile, protein/creatinine ratio in urine and kidney function tests were done. Results The mean CIMT (mm) was significantly higher in patients with NS (0.477 ± 0.04) compared to controls (0.39 ± 0.03) (P < 0.001) even when compared across different age groups. 60% of patients had received non-steroid immunosuppressive therapy. CIMT was significantly higher in patients receiving non-steroid immunosuppressive therapy than those receiving steroids alone. Subsequently, CIMT had significant positive correlation to duration of the disease (p = 0.05), body mass index (BMI) (p = 0.03), number of relapses (p = 0.01) and diastolic blood pressures (p = 0.003). Conclusion Children with NS had significantly higher CIMT than control group. CIMT was positively correlated to disease duration, number of relapses and BMI. It was significantly higher among patients receiving non-steroid immunosuppressive therapy than those receiving steroids alone.

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Endothelial Dysfunction in Children with Steroid-Resistant Nephrotic Syndrome

Cited by 3 publications

References 15 publications

Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome

Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome

Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome

Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome

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