Endothelial dysfunction in hypertension: cause or effect?

Gorshkov, A. Yu.; Fedorovich, A.A.; Драпкина, О. М.

doi:10.15829/1728-8800-2019-6-62-68

Cited by 10 publications

(2 citation statements)

References 62 publications

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“…It shows that a 1% increase in FMD reduces the risk of cardiovascular disease by 13% 13 . Similarly, FMD is associated with the prevalence of hypertension 14 . The sustained elevation of blood pressure leads to mechanical damage to the vascular endothelium and the production of a range of harmful substances, which can further damage the vascular endothelium, leading to a decline in FMD 15 .…”

Section: Introductionmentioning

confidence: 99%

“… 13 Similarly, FMD is associated with the prevalence of hypertension. 14 The sustained elevation of blood pressure leads to mechanical damage to the vascular endothelium and the production of a range of harmful substances, which can further damage the vascular endothelium, leading to a decline in FMD. 15 Therefore, in addition to regular observation of blood pressure changes, targeting vascular damage, by observing changes in contractile and diastolic factors secreted by the vascular endothelium in hypertensive patients, and by correctly evaluating vascular endothelial function in hypertensive patients through the detection of FMD, it provides a new therapeutic concept for early diagnosis and prevention of hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Exercise interventions for the effect of endothelial function in hypertensive patients: A systematic review and meta‐analysis

Liang,

Song,

Yao

et al. 2024

J of Clinical Hypertension

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Endothelial dysfunction is crucial factor to the hypertension occurrence, and controversy remains regarding the effect of exercise on improving endothelial function in hypertensive patients. The authors used meta‐analysis to evaluate the intervention effect of exercise on endothelial function in hypertensive patients and to investigate exercise protocols that may have a greater intervention effect. A total of 37 studies and a total of 2801 participants were included. The results were as follows: endogenous nitric oxide (NO)[SMD = .89, 95% CI (.48, 1.30), p < .0001], endothelin‐1 (ET‐1): [SMD = −.94, 95% CI (−1.15, −.73), p <. 0001], flow‐mediated dilation (FMD) [SMD = −.57, 95% CI (.36, .79), p < .000001]. In subgroup analysis, high‐intensity aerobic exercise, with a single exercise duration of 35–50 min, 3–4 times/week for a total of 10–12 weeks, had the largest amount of intervention effect on NO, and moderate‐intensity resistance exercise, with a single exercise duration of ≥60 min, 6 times/week for a total of 15–18 weeks, had the largest amount of intervention effect on ET‐1. In conclusion, exercise can improve NO levels, FDM levels, and reduce ET‐1 secretion of hypertension patients, thereby improve their endothelial function. The ideal intervention effect of improving NO level was more likely to be obtained by taking the exercise prescription of high‐intensity aerobic exercise with a single exercise duration of 35–50 min, 3–4 times/week for 10–12 weeks; the ideal intervention effect of improving ET‐1 was more likely to be obtained by taking the exercise prescription of oderate ‐intensity resistance exercise with a single exercise duration of ≥60 min, 6 times/week for 15–18 weeks.

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Section: Introductionmentioning

confidence: 99%