Endothelial Dysfunction in Mexican Obese Children, is there A Role of the Gut Microbiota?

Nirmalkar, Khemlal

doi:10.15226/2374-8354/4/1/00127

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…To the best of our knowledge, there is no published report about the association between EDF markers and gut microbiota in any population. Therefore, we aimed to investigate whether there is an association between EDF markers and the intestinal microbiota in obese Mexican children and adolescents [24].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Endothelial Dysfunction Markers in Obese Mexican Children and Adolescents

et al. 2018

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Obesity is a metabolic disease characterized by low-grade inflammation and accompanied by dyslipidemia and up-regulation of other bioactive molecules, creating a predisposition to endothelial dysfunction and metabolic syndrome. We studied the association between gut microbiota diversity and endothelial dysfunction (EDF) markers in obese Mexican children and adolescents. We examined clinical data including metabolic factors and EDF markers in blood samples. Gut bacterial diversity was characterized by high-throughput sequencing of V3-16S rDNA libraries. Triglycerides, insulin, homeostasis model assessment-insulin resistant (HOMA-IR), leptin, C-reactive protein (CRP), and EDF marker intercellular adhesion molecule 1 (ICAM-1) were significantly higher in obese children and adolescents. Multivariate analysis showed statistically significant positive associations between vascular cell adhesion molecule 1 (VCAM-1) and Veillonellaceae, and between ICAM-1 and Ruminococcus in obese children. In obese adolescents, there was a statistically significant positive association between total cholesterol and Ruminococcus, and between ICAM-1 and Bacteroides. LEfSe analysis showed that the genus Lactobacillus and family Coriobacteriaceae were enriched in children, and genera Collinsella and Prevotella were enriched in obese adolescents. Obese children and adolescents had higher levels of insulin resistance and metabolic syndrome. These results suggest that obese Mexican children and adolescents had increased levels of CRP and a reduction of adiponectin, which causes higher expression of EDF markers, affecting endothelial function and associating with changes in the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Endothelial Dysfunction Markers in Obese Mexican Children and Adolescents

et al. 2018

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“…This condition will enhance the development of metabolic disorder obesity along with lower physical activity. In has been also suggested a possible association of endothelial dysfunction with an alteration of gut microbiota in obese children [49]. Thus, it is considered that the gut microbiota plays an important role in weight regulation and may even be partly responsible for the development of obesity.…”

Section: Gut Microbiota and Obesitymentioning

confidence: 99%

Current Insight into the Role of Gut Microbiota in Mexican Childhood Obesity

HornyákM¹,

Csı́k²,

Lukacs³

et al. 2017

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Obesity is an epidemic multifactorial metabolic malady worldwide. This review insights the influence of gut microbiota in developing obesity in Mexican children. High prevalence of childhood obesity in Mexico draws the importance to look for a therapeutic target to control it. Gut microbial disturbances in obese children may have a role in their metabolism. Excessive Short chain fatty acids produced by obese gut microbiota, present an additional energy which causes an imbalance in energy regulation. Thus Manipulating gut microbiota via diverse diet, probiotics and prebiotics treatment can provide a novel approach to treat obesity and other metabolic disorders, including type 2 diabetes and Metabolic syndrome.

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Endothelial Dysfunction in Mexican Obese Children, is there A Role of the Gut Microbiota?

Cited by 2 publications

References 19 publications

Gut Microbiota and Endothelial Dysfunction Markers in Obese Mexican Children and Adolescents

Gut Microbiota and Endothelial Dysfunction Markers in Obese Mexican Children and Adolescents

Current Insight into the Role of Gut Microbiota in Mexican Childhood Obesity

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