Endothelıal dysfunctıon ın patıents wıth prımary Sjögren’s syndrome

Pırıldar, Timur; Tıkız, Canan; Özkaya, Sabriye; Tarhan, Serdar; Ütük, Ozan; Tıkız, Hakan; Tezcan, Uğur Kemal

doi:10.1007/s00296-005-0599-5

Cited by 32 publications

(21 citation statements)

References 15 publications

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“…Compared to patients with CV disease risk factors, circulating anti-SSA/Ro and anti-SSB/La antibodies (P ≤ 0.001 and P ≤ 0.04, respectively), leucopenia (P ≤ 0.02), hypergammaglobulinaemia (P ≤ 0.001) and hypocomplementaemia (P ≤ 0.001) were more common in patients without any CV disease risk factors. Based on these findings and the previous demonstration that anti-SSA/SSB antibodies and leucopenia are associated with subclinical ATS in patients with pSS [14,15], we investigated the possible relationship between these laboratory characteristics of pSS and CV disease risk factors in the entire cohort. Patients with evidence of circulating anti-SSA/SSB antibodies were characterized by a higher frequency of parotid enlargement (P ≤ 0.0001), purpura (P ≤ 0.005), extra-glandular involvement (P ≤ 0.0001), lymphoma (P ≤ 0.02), hypergammaglobulinaemia, rheumatoid factor positivity, leucopenia (P ≤ 0.0001 for all) and use of HCQ (P ≤ 0.005) and IS therapies (P ≤ 0.03).…”

Section: Resultsmentioning

confidence: 99%

“…Although patients with pSS show signs of precocious subclinical ATS [12,16], conclusive evidence of increased CV events or deaths in these patients is currently lacking. In addition, the prevalence and role of traditional CV disease risk factors and their interaction with disease-related features of this systemic autoimmune disorder have not been fully investigated [12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Small case-control studies have demonstrated signs of endothelial dysfunction and precocious arterial wall damage in pSS patients without previous CV disorders [12][13][14][15][16]. Disease duration and several clinical and immunological features, including joint involvement, parotid swelling, Raynaud's phenomenon, leucopenia and anti-SSA/Ro and anti-SSB/La antibodies, seem to contribute to subclinical ATS damage in these patients [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Disease duration and several clinical and immunological features, including joint involvement, parotid swelling, Raynaud's phenomenon, leucopenia and anti-SSA/Ro and anti-SSB/La antibodies, seem to contribute to subclinical ATS damage in these patients [12][13][14][15][16]. By contrast, the prevalence and the role of traditional CV disease risk factors in the induction of precocious ATS have not been extensively investigated [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population‐based multicentre cohort study

et al. 2015

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Abstract. Bartoloni E, Baldini C, Schillaci G, Quartuccio L, Priori R, Carubbi F, Bini V, Alunno A, Bombardieri S, De Vita S, Valesini G, Giacomelli R, Gerli R (University of Perugia, Perugia; University of Pisa, Pisa; Terni University Hospital, Terni; University of Udine, Udine; Sapienza University of Rome, Rome; University of L'Aquila, L'Aquila; and University of Perugia, Perugia; Italy). Cardiovascular disease risk burden in primary Sj€ ogren's syndrome: results of a population-based multicentre cohort study. J Intern Med 2015; 278: 185-192.Objective. Systemic autoimmune diseases, in particular systemic lupus erythematosus and rheumatoid arthritis, are characterized by a high risk of premature cardiovascular (CV) events. Diseaserelated characteristics and traditional CV disease risk factors may contribute to atherosclerotic damage. However, there are limited data on the risk of overt CV events in primary Sj€ ogren's syndrome (pSS).Methods. We retrospectively analysed a cohort of patients with 1343 pSS. Disease-related clinical and laboratory data, traditional CV disease risk factors and overt CV events were recorded. Prevalence of traditional CV disease risk factors and of major CV events was compared between a subgroup of 788 female patients with pSS aged from 35 to 74 years and 4774 age-matched healthy women.Results. Hypertension and hypercholesterolaemia were more prevalent, whereas smoking, obesity and diabetes mellitus were less prevalent, in women with pSS than in control subjects. Cerebrovascular events (2.5% vs. 1.4%, P = 0.005) and myocardial infarction (MI) (1.0% vs. 0.4%, P = 0.002) were more common in patients with pSS. In the whole population, central nervous system involvement (odds ratio (OR) 5.6, 95% confidence interval (CI) 1.35-23.7, P = 0.02) and use of immunosuppressive therapy (OR 1.9, 95% CI 1.04-3.70, P = 0.04) were associated with a higher risk of CV events. Patients with leucopenia had a higher risk of angina (P = 0.01).Conclusions. pSS is associated with an increased risk of cerebrovascular events and MI. Disease-related clinical and immunological markers may have a role in promoting CV events.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population‐based multicentre cohort study

et al. 2015

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“…In line with our findings, the majority of the studies have observed an excess of atherosclerosis, despite using different methods. Therefore, endothelial dysfunction (11)(12)(13)(14), increased arterial stiffness (11), increased carotid intima-media thickening (CIMT) (9), and abnormal ankle brachial index (15) have been more or less consistently described in these patients. There is only one study in particular that to our knowledge has investigated PWV in primary SS.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of and Factors Associated With Increased Arterial Stiffness in Patients With Primary Sjögren's Syndrome

Sabio

Sánchez-Berná

Martínez-Bordonado

et al. 2015

Arthritis Care & Research

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Objective. To compare the presence of subclinical atherosclerosis measured by means of pulse wave velocity (PWV) in women with primary Sjögren's syndrome (SS) versus a healthy age-and sex-matched control group, and to identify factors independently associated with PWV in primary SS. Methods. Forty-four women with primary SS and 78 age-matched healthy women without overt cardiovascular (CV) diseases were assessed for traditional and nontraditional CV risk factors. PWV was also performed. A linear regression analysis was used to identify factors independently associated with PWV in primary SS. Results. Women with primary SS had significantly higher PWV than controls (P ‫؍‬ 0.030), and the frequency of increased PWV was significantly higher in this group (25% versus 8%; P ‫؍‬ 0.013). The proportion of patients ages <50 years (ratio 4.6) with increased PWV was almost 2-fold higher than those ages >50 years (ratio 2.4) with respect to controls. Positivity for anti-SSB was more frequent in patients with normal PWV than in those with increased PWV (61% versus 18%; P ‫؍‬

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Functional impairment of the arterial wall in primary Sjögren's syndrome: Combined action of immunologic and inflammatory factors

Gerli¹,

Vaudo²,

Bocci³

et al. 2010

Arthritis Care & Research

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Objective. Primary Sjö gren's syndrome (SS) shares clinical and serologic features with rheumatoid arthritis and systemic lupus erythematosus, 2 diseases characterized by acceleration of atherosclerosis. Signs of precocious atherosclerosis have also been shown in SS, although the pathogenic basis of early arterial damage is unclear. The arterial wall was functionally evaluated in SS subjects with analysis of the role played by disease-related factors. Methods. Endothelium-dependent flow-mediated vasodilation (FMV) and endothelium-independent nitrate-mediated vasodilation (NMV) were evaluated in 45 women with SS and 59 age-matched female controls. In addition, serum soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule 1 (VCAM-1), and nitrotyrosine were detected. Results. Although patient FMV values did not differ from those of control subjects (mean ؎ SD 7.4 ؎ 3.6 versus 7.7 ؎ 1.9; not significant), NMV was lower in SS patients than in controls (mean ؎ SD 8.1 ؎ 3.5 versus 10.3 ؎ 2.1; P < 0.001). Patient NMV was inversely correlated with soluble VCAM-1 levels (r ‫؍‬ ؊0.38, P ‫؍‬ 0.001) and directly correlated with leukocyte count (r ‫؍‬ 0.26, P ‫؍‬ 0.03). An NMV decrease was confirmed in SS patient subsets with evidence of leukopenia, rheumatoid factor, anti-SSB antibodies, and joint involvement. However, patients with joint involvement or parotid enlargement, 2 of the sites mainly affected by chronic inflammation in SS, had an FMV lower than controls and patients without these clinical features. Conclusion. Our results suggest that a functional impairment of the arterial wall may sustain early phases of atherosclerotic damage in SS. A combined effect of disease-related chronic inflammatory and immunologic factors appears to support dysfunction of endothelium and vascular smooth muscle cells, respectively.

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Endothelıal dysfunctıon ın patıents wıth prımary Sjögren’s syndrome

Cited by 32 publications

References 15 publications

Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population‐based multicentre cohort study

Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population‐based multicentre cohort study

Prevalence of and Factors Associated With Increased Arterial Stiffness in Patients With Primary Sjögren's Syndrome

Functional impairment of the arterial wall in primary Sjögren's syndrome: Combined action of immunologic and inflammatory factors

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