Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species

Furieri, Lorena Barros; Galán, María; Avendaño, María Soledad; García-Redondo, Ana B.; Aguado, Ana M.; Martí­nez, Sonia Gómez; Cachofeiro, Victoria; Bartolomé, M V; Alonso, María J.; Vassallo, Dalton Valentim; Salaíces, Mercedes

doi:10.1111/j.1476-5381.2011.01203.x

Cited by 65 publications

(54 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mercury treatment also increases 5-HT-induced vasoconstriction in coronary arteries (27). A similar increase of vascular reactivity was obtained with lead treatments for 30 days or more (57).…”

Section: Effects Of Heavy Metals On Vascular Reactivity Changes In Vasupporting

confidence: 60%

“…This increased free radical generation is usually responsible for the reduction of NO bioavailability. Thus, we have observed that: 1) vascular O 2 .-production and plasma oxidative stress are greater in rats treated with mercury chloride, 2) mercury treatment also increases vascular mRNA levels of the NAD(P)H oxidase subunits NOX-1 and NOX-4 (27), and 3) several antioxidants abolish the increased vasoconstrictor responses observed in vessels from mercury-treated rats (25,27).…”

Section: Role Of Free Radicals In the Effects Of Mercury Lead And Gamentioning

confidence: 83%

“…Previous studies have demonstrated that mercury decreases the production of nitric oxide (NO) and alters the expression of NO synthase (NOS) (27). HgCl 2 at concentrations of 0.5 to 10 µM produces vasoconstriction, reduces the endothelial vasodilator response and stimulates a cyclooxygenase (COX)-derived vasoconstrictor (28).…”

Section: Mercurymentioning

confidence: 99%

See 2 more Smart Citations

Toxic effects of mercury, lead and gadolinium on vascular reactivity

Vassallo

Simões

Furieri

et al. 2011

Braz J Med Biol Res

View full text Add to dashboard Cite

Heavy metals have been used in a wide variety of human activities that have significantly increased both professional and environmental exposure. Unfortunately, disasters have highlighted the toxic effects of metals on different organs and systems. Over the last 50 years, the adverse effects of chronic lead, mercury and gadolinium exposure have been underscored. Mercury and lead induce hypertension in humans and animals, affecting endothelial function in addition to their other effects. Increased cardiovascular risk after exposure to metals has been reported, but the underlying mechanisms, mainly for short periods of time and at low concentrations, have not been well explored. The presence of other metals such as gadolinium has raised concerns about contrast-induced nephropathy and, interestingly, despite this negative action, gadolinium has not been defined as a toxic agent. The main actions of these metals, demonstrated in animal and human studies, are an increase of free radical production and oxidative stress and stimulation of angiotensin I-converting enzyme activity, among others. Increased vascular reactivity, highlighted in the present review, resulting from these actions might be an important mechanism underlying increased cardiovascular risk. Finally, the results described in this review suggest that mercury, lead and gadolinium, even at low doses or concentrations, affect vascular reactivity. Acting via the endothelium, by continuous exposure followed by their absorption, they can increase the production of free radicals and of angiotensin II, representing a hazard for cardiovascular function. In addition, the actual reference values, considered to pose no risk, need to be reducedResearch supported by CAPES and CNPq/FAPES/ FUNCITEC (#39767531/07), Brazil, and MCINN (#SAF 2009-07201) and ISCIII (Red RECAVA, #RD06/0014/0011), Spai

show abstract

Section: Effects Of Heavy Metals On Vascular Reactivity Changes In Vasupporting

confidence: 60%

Section: Role Of Free Radicals In the Effects Of Mercury Lead And Gamentioning

confidence: 83%

See 1 more Smart Citation

Toxic effects of mercury, lead and gadolinium on vascular reactivity

Vassallo

Simões

Furieri

et al. 2011

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…and 0.05 µg/kg b.w. per day, expressed as mercury, respectively)) of Wistar rats promoted endothelial dysfunction of coronary arteries, as demonstrated by decreased nitric oxide bioavailability induced by oxidative stress (Furieri et al, 2011a). Moreover, this treatment promoted contractility dysfunction as a result of reduced Na + /K + -ATPase activity, decreased sarco/endoplasmic reticulum Ca 2+ -ATPase and sodium/calcium exchanger and increased phospholamban protein expression in isolated (Langendorff perfused) hearts of the exposed rats.…”

Section: Mechanisms Of Vascular/cardiovascular Toxicitymentioning

confidence: 98%

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

2012

EFS2

465

160

View full text Add to dashboard Cite

EFSA was asked by the European Commission to consider new developments regarding inorganic mercury and methylmercury toxicity and evaluate whether the Joint FAO/WHO Expert Committee on Food Additives (JECFA) provisional tolerable weekly intakes for methylmercury of 1.6 µg/kg body weight (b.w.) and of 4 µg/kg b.w. for inorganic mercury were still appropriate. In line with JECFA, the CONTAM Panel established a tolerable weekly intake (TWI) for inorganic mercury of 4 µg/kg b.w., expressed as mercury. For methylmercury, new developments in epidemiological studies from the Seychelles Child Developmental Study Nutrition Cohort have indicated that n-3 long-chain polyunsaturated fatty acids in fish may counteract negative effects from methylmercury exposure. Together with the information that beneficial nutrients in fish may have confounded previous adverse outcomes in child cohort studies from the Faroe Islands, the Panel established a TWI for methylmercury of 1.3 µg/kg b.w., expressed as mercury. The mean dietary exposure across age groups does not exceed the TWI for methylmercury, with the exception of toddlers and other children in some surveys. The 95 th percentile dietary exposure is close to or above the TWI for all age groups. High fish consumers, which might include pregnant women, may exceed the TWI by up to approximately six-fold. Unborn children constitute the most vulnerable group. Biomonitoring data from blood and hair indicate that methylmercury exposure is generally below the TWI in Europe, but higher levels are also observed. Exposure to methylmercury above the TWI is of concern. If measures to reduce methylmercury exposure are considered, the potential beneficial effects of fish consumption should also be taken into account. Dietary inorganic mercury exposure in Europe does not exceed the TWI, but inhalation exposure of elemental mercury from dental amalgam is likely to increase the internal inorganic mercury exposure; thus the TWI might be exceeded. This opinion focuses only on the risks related to dietary inorganic mercury and methylmercury exposure and does not assess the nutritional benefits linked to certain foods (e.g. fish and other seafood).A call for annual collection of chemical contaminant occurrence data in food and feed, including mercury, was issued by EFSA in December 2010. In response, EFSA received 59 820 results on mercury in food from 20 European countries, mainly covering the period from 2004 to 2011. A total number of 59 650 results were described with sufficient detail to be used in the statistical analysis of the respective food groups; 98.2 % of the samples were for total mercury, 1.8 % for methylmercury and three samples for inorganic mercury.All the 20 food groups available at the first level of FoodEx were covered in the current data collection. The food groups 'Fish and other seafood' and 'Meat and meat products' dominated the food product coverage with 36.8 % and 17.6 % respectively. These were followed by 'Grain and grain-based products' at 7.8 % and 'Vegetables an...

show abstract

“…Special interest is now being given to influence of mercury [9,10]. There is information on low doses of mercury effect on endothelial modulation of coronary blood circulation [10].…”

Section: Introductionmentioning

confidence: 99%

The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts

Starodub¹,

Samokhina²

2013

ABC

View full text Add to dashboard Cite

CoCl 2 introduction increased cathepsin G activity in the heart and liver as well as endothelial elastase (EEl) in kidney that indicated the development of destructive processes. CoCl 2 introduction decreased EEl and cathepsin G activities in blood serum and cathepsin G in lungs. HgCl 2 injection decreased EEl in blood serum, heart, liver, kidney and cathepsin G in blood serum. These decreasing of proteinases activities may be caused by cytotoxic effects of heavy metals and/or the inclusion of these proteases in the destructive processes and absence of their synthesis and/or release.

show abstract

Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species

Cited by 65 publications

References 39 publications

Toxic effects of mercury, lead and gadolinium on vascular reactivity

Toxic effects of mercury, lead and gadolinium on vascular reactivity

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts

Contact Info

Product

Resources

About