Endothelial Function, But Not Carotid Intima-Media Thickness, Is Affected Early in Menopause and Is Associated with Severity of Hot Flushes

Bechlioulis, Aris; Kalantaridou, Sophia Ν.; Naka, Katerina K.; Chatzikyriakidou, Anthoula; Calis, Karim A.; Makrigiannakis, Antonis; Papanikolaou, Odysseas; Kaponis, Apostolos; Katsouras, Christos S.; Georgiou, Ioannis; Chrousos, George P.; Michalis, Lampros K.

doi:10.1210/jc.2009-2262

Cited by 130 publications

(86 citation statements)

References 35 publications

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“…Endothelial function was assessed in all participants by measurement of endotheliumdependent vasodilation in the right brachial artery in response to hand hyperemia, based on previously described methodology (20), according to recently published recommendations in children and adolescents (7). Images were acquired at baseline and every 30 seconds from the first to the third minute after deflation of a wrist cuff inflated to ϳ250 mm Hg for 4 minutes for measurement of FMD.…”

Section: Vascular Studiesmentioning

confidence: 99%

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Changes in vascular function and structure in juvenile idiopathic arthritis

Vlahos¹,

Theocharis²,

Bechlioulis³

et al. 2011

Arthritis Care & Research

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Objective. Chronic inflammatory diseases in adults have been associated with increased cardiovascular risk and impaired vascular function. We aimed to assess the presence of early vascular dysfunction in patients with juvenile idiopathic arthritis (JIA) and investigate the role of inherent inflammatory process of JIA in vascular health. Methods. Thirty patients with JIA (age range 7-18 years) were compared to 33 age-and sex-matched controls. Endothelial function (brachial artery flow-mediated dilation [FMD]), carotid intima-media thickness (IMT), and arterial stiffness were examined. Endothelial inflammation was assessed by intercellular adhesion molecule 1 (ICAM-1) and P-selectin measurements. Results. Patients with JIA showed decreased FMD compared to controls (P ‫؍‬ 0.001), independent of age (P ‫؍‬ 0.9 among age subgroups). Baseline differences in erythrocyte sedimentation rate, ICAM-1, and glucose between the 2 groups accounted for the difference in FMD. The presence of systemic JIA was associated with greater IMT compared to patients with oligoarticular disease, polyarticular disease, or controls (P ‫؍‬ 0.014, P ‫؍‬ 0.069, and P ‫؍‬ 0.046, respectively). The difference in IMT between systemic versus oligoarticular/polyarticular JIA was attributed to the following risk factors: age, body mass index, blood pressure, disease activity, and corticosteroids use. There were no differences in arterial stiffness indices between JIA patients and controls or between patients with systemic versus nonsystemic disease. Conclusion. Endothelial function is impaired in patients with JIA at a very young age, while IMT is increased only in the presence of systemic JIA. Vascular dysfunction may be partly attributed to the effects of disease-related characteristics (inflammation, disease activity, and medications).

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Section: Vascular Studiesmentioning

confidence: 99%

“…Common carotid artery (CCA) IMT measurement was performed in all participants using a standardized protocol published previously (20), based on recently published recommendations in children and adolescents (7). Three consecutive longitudinal images of each CCA 1-2 cm proximal to the bifurcation were acquired.…”

Section: Vascular Studiesmentioning

confidence: 99%

Changes in vascular function and structure in juvenile idiopathic arthritis

Vlahos¹,

Theocharis²,

Bechlioulis³

et al. 2011

Arthritis Care & Research

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“…Emerging evidence suggests that VMS and cardiovascular risk are related, possibly through inflammation, endothelial dysfunction, 3 or activity of the sympathetic nervous system. 4 The directions of the relationships are unclear, however.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have found that women with VMS have less favourable cardiovascular markers than those reporting no symptoms. [5][6][7][8] Other studies have reported reduced endothelial function, 3,9 increased intima media thickness (IMT), 10 and coronary artery calcifications (CAC), 11 among women with hot flushes. In another study, however, hot flushes were not significantly associated with blood pressure, 12 endothelial function, 13 or lipids and inflammatory markers.…”

Section: Introductionmentioning

confidence: 99%

Hot flushes and night sweats are associated with coronary heart disease risk in midlife: a longitudinal study

Herber-Gast

Brown

Mishra

2014

BJOG

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Objective The purpose of this study was to investigate associations between vasomotor menopausal symptoms (VMS), i.e. hot flushes and night sweats, and the incidence of coronary heart disease (CHD).Design A prospective cohort study.Setting and population 11 725 women, aged 45-50 years at baseline in 1996, were followed up at 3-year intervals for 14 years.Methods Self-reported VMS and incident CHD were measured at each survey.Main outcome measure We determined the association between VMS and CHD at the subsequent survey, using generalised estimating equation analysis, adjusting for time-varying covariates.Results At baseline, 14% reported rarely, 17% reported sometimes, and 7% reported often having night sweats. During follow-up, 187 CHD events occurred. In the age-adjusted analysis, women who reported their frequency of experiencing hot flushes and night sweats as 'often' had a greater than two-fold increased odds of CHD (OR hot flushes 2.18, 95% CI 1.49-3.18; OR night sweats 2.38, 95% CI 1.62-3.50) compared with women with no symptoms (P trend < 0.001 for frequency of symptoms). Adjustment for menopausal status, lifestyle factors, body mass index, diabetes, and hypertension attenuated the associations (OR hot flushes 1.70, 95% CI 1.16-2.51, P trend = 0.01; OR night sweats 1.84, 95% CI 1.24-2.73), P trend = 0.004).Conclusions Women who report having hot flushes or night sweats 'often' have an increased risk of developing CHD over a period of 14 years, even after taking the effects of age, menopause status, lifestyle, and other chronic disease risk factors into account.

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“…Satoh and Ohashi (2005) reported that 19.7% of women believe that menopausal symptoms are not symptoms of a sickness and prefer to wait until the menopausal symptoms disappear. Various studies showed that women with severe menopausal symptoms have risks of a decrease in vascular function and insulin resistance in the future (Thurston et al, 2012;Bechlioulis et al, 2010). During health examinations, physicians and/or nurses or nurse practitioners can provide information on appropriate treatments and make appropriate referrals for advanced care as needed.…”

Section: Discussionmentioning

confidence: 99%

Differences in strategies for coping with menopausal symptoms in full-time workers and part-time workers in Japan

Matsuzaki¹,

Fukuoka²,

Uemura³

et al. 2018

Int. J. Nurs. Midwifery

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Working hours and working conditions are different for full-time workers and part-time workers. In this study, it was hypothesized that the strategies for coping with menopausal symptoms, such as hot flashes, night sweats and insomnia, and the proportion of women receiving clinical care differ between full-time and part-time workers. Four hundred and eighty-seven Japanese female workers aged 45 to 60 years responded to a health questionnaire about their understanding of menopause and their strategies for coping with menopausal symptoms. Based on the surveyed responses, the proportions of women with menopausal symptoms were 43.0% (80/186) in full-time workers and 48.2% (145/301) in part-time workers. There was no significant difference in the female worker response rate, nor were there significant differences in the proportions of full-time workers and part-time workers who had an understanding of menopause causes and treatments and who were able to cope with menopausal-related symptoms. However, there were significantly more full-time workers than part-time workers who received routine clinical care and who visited a hospital. On the other hand, significantly more part-time workers than full-time workers exercised and took dietary supplements as a means of coping with their symptoms. There are differences between female full-time and part-time workers regarding the strategies employed for coping with menopausal symptoms. The proportion of women receiving clinical care for their symptoms is greater among full-time employees than part-time employees. A physical examination can be a valuable opportunity for working women with menopausal symptoms to receive advice from a doctor or a nurse practitioner.Key words: Menopause, coping strategy, full-time workers, part-time workers. INTRODUCTIONIn 2007, the employment rate for Japanese females aged 15 to 64 years was more than 60%, and by 2013, this percentage had increased to 62.5% (SBJ, 2013). In 2011, the proportion of female part-time workers reached 45.9% (MHLW, 2011). Recently, part-time work has become a more popular option and has enabled Japanese women 2 Int. J. Nurs. Midwifery to maintain a balance between work and family life. In Japan, various types of female employment can facilitate greater equality by providing opportunities for women to demonstrate their ability to achieve a work-family life balance. Yoshii and Yamazaki (1999) reported that working conditions influence the status of health, though the effects of working conditions on menopausal symptoms are unclear. Researchers have shown that the frequencies of hot flushes and vaginal dryness in part-time workers were greater than those in full-time workers (Li et al., 2003). Previously, it was reported that the association of job-related stress with menopausal symptoms was different in full-time workers and part-time workers (Matsuzaki et al., 2017).Ways for coping with menopausal symptoms such as hot flashes, night sweats and insomnia may be different according to occupation. For example, ways for copin...

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Endothelial Function, But Not Carotid Intima-Media Thickness, Is Affected Early in Menopause and Is Associated with Severity of Hot Flushes

Cited by 130 publications

References 35 publications

Changes in vascular function and structure in juvenile idiopathic arthritis

Changes in vascular function and structure in juvenile idiopathic arthritis

Hot flushes and night sweats are associated with coronary heart disease risk in midlife: a longitudinal study

Differences in strategies for coping with menopausal symptoms in full-time workers and part-time workers in Japan

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