Endothelial function in contemporary patients with repaired coarctation of aorta

Rm, Radke; Gp, Diller; Duck, Mary M; Orwat, Stefan; Hartmann, Dorothee; Thum, Thomas; Baumgartner, Helmut

doi:10.1136/heartjnl-2014-305739

Cited by 20 publications

(19 citation statements)

References 31 publications

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“…Individuals with CoA have endothelial dysfunction that persists despite successful repair in many individuals, including those without hypertension. There may be a subset of patients with normal endothelial function, 399 suggesting that a subset of individuals with CoA may have a more concerning vascular risk profile. The contribution of endothelial dysfunction to coronary arterial disease is not yet known, but there are existing markers of subclinical atherosclerosis, including increased carotid and femoral intima-media thickness in the adult CoA population.…”

Section: Diagnosis and Managementmentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

180

136

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ABSTRACT:Life expectancy and quality of life for those born with congenital heart disease (CHD) have greatly improved over the past 3 decades. While representing a great advance for these patients, who have been able to move from childhood to successful adult lives in increasing numbers, this development has resulted in an epidemiological shift and a generation of patients who are at risk of developing chronic multisystem disease in adulthood. Noncardiac complications significantly contribute to the morbidity and mortality of adults with CHD. Reduced survival has been documented in patients with CHD with renal dysfunction, restrictive lung disease, anemia, and cirrhosis. Furthermore, as this population ages, atherosclerotic cardiovascular disease and its risk factors are becoming increasingly prevalent. Disorders of psychosocial and cognitive development are key factors affecting the quality of life of these individuals. It is incumbent on physicians who care for patients with CHD to be mindful of the effects that disease of organs other than the heart may have on the well-being of adults with CHD. Further research is needed to understand how these noncardiac complications may affect the long-term outcome in these patients and what modifiable factors can be targeted for preventive intervention.

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Section: Diagnosis and Managementmentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

180

136

View full text Add to dashboard Cite

show abstract

“…Prerepair hypertension may not be in the causal pathway of endothelial dysfunction as abnormal vascular function does not correlate with age at repair. In addition, a recent study revealed no significant difference in endothelial function between their patients with coarctation and healthy controls 6. These conflicting data now raise the possibility that only select individuals with coarctation have an overt intrinsic arteriopathy leading to vascular dysfunction.…”

Section: Vascular Dysfunction: the Two-hit Hypothesismentioning

confidence: 97%

Long-term outcomes in coarctation of the aorta: an evolving story of success and new challenges

Bhatt

Yeh

2015

Heart

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“…Among the pathophysiological changes in HF, endothelial dysfunction is highlighted and is present even in the early stages . However, the presence of endothelial dysfunction in patients with congenital heart disease is controversial because some studies have demonstrated the occurrence of endothelial dysfunction in these patients, whereas other studies have not confirmed this condition . Research in individuals with HF has shown that these individuals present compromised systemic endothelial function of the cutaneous microcirculation .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of systemic microvascular reactivity in adults with congenital heart disease

Marino

Lopes

Borges

et al. 2018

Congenital Heart Disease

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Adults with congenital heart disease present a higher baseline cutaneous microvascular blood flow than healthy controls and do not present systemic microvascular endothelial dysfunction. Nevertheless, endothelium-independent microvascular reactivity is blunted, suggesting an altered vascular smooth muscle response or vascular structural alterations. Finally, patients with a lower functional capacity presented a greater microvascular basal blood flow than subjects with a higher functional capacity.

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Endothelial function in contemporary patients with repaired coarctation of aorta

Cited by 20 publications

References 31 publications

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Long-term outcomes in coarctation of the aorta: an evolving story of success and new challenges

Evaluation of systemic microvascular reactivity in adults with congenital heart disease

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