D25. O Brave New World! Omics, System Biology, and New Molecular Mechanisms of Pulmonary Hypertension 2020
DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6363
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Endothelial GATA6 Coordinates Cross-Talk Between BMP and Oxidative Stress Axis in Pulmonary Arterial Hypertension

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“…The elevated levels of Nogo-B during ER stress lead to restructuring and disruption of the mitochondria-ER unit, which eventually suppress apoptosis; thus, targeting Nogo-B can be a potential selective therapeutic strategy against PAH [ 133 , 134 ]. Of note, mice with conditional deletion of GATA-6, a member of the GATA family of zinc-finger transcription factors, in endothelial cells display an elevation of ER stress markers and worsening of hypoxia-induced PAH [ 135 , 136 ]. This result reveals that endothelial cells play a critical role in triggering ER stress in hypoxic mice.…”
Section: Pulmonary Arterial Hypertensionmentioning
confidence: 99%
“…The elevated levels of Nogo-B during ER stress lead to restructuring and disruption of the mitochondria-ER unit, which eventually suppress apoptosis; thus, targeting Nogo-B can be a potential selective therapeutic strategy against PAH [ 133 , 134 ]. Of note, mice with conditional deletion of GATA-6, a member of the GATA family of zinc-finger transcription factors, in endothelial cells display an elevation of ER stress markers and worsening of hypoxia-induced PAH [ 135 , 136 ]. This result reveals that endothelial cells play a critical role in triggering ER stress in hypoxic mice.…”
Section: Pulmonary Arterial Hypertensionmentioning
confidence: 99%