2023
DOI: 10.1101/2023.10.23.563477
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Endothelial Gene Regulatory Elements Associated With Cardiopharyngeal Lineage Differentiation

Ilaria Aurigemma,
Olga Lanzetta,
Andrea Cirino
et al.

Abstract: Endothelial cells (EC) differentiate from multiple sources, including the cardiopharyngeal mesoderm, which gives rise also to cardiac and branchiomeric muscles. Here, we used a cardiogenic mesoderm cell differentiation model that also activates an endothelial transcription program to identify endothelial regulatory elements activated in early cardiogenic mesoderm. Integrating our chromatin remodeling and gene expression data with available single-cell RNA-seq data from mouse embryos, we identified 101 putative… Show more

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