Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults
Christian Rønn,
Andreas Dehlbæk Knudsen,
Nicoline Stender Arentoft
et al.
Abstract:ObjectivesEndothelial injury may promote declining lung function. We aimed to investigate in well-treated persons living with HIV (PLWH) whether elevated levels of thrombomodulin (TM) and syndecan-1 (SDC1) are associated with excess lung function decline and worsening dyspnea.MethodsA prospective cohort study comprising patients from the Copenhagen municipality. We included 698 PLWH with undetectable viral load. Biomarkers and demographics were measured at baseline, spirometry [forced expiratory volume in one … Show more
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