Endothelial Lipase Is Increased In Vivo by Inflammation in Humans

Badellino, Karen O.; Wolfe, Megan L.; Reilly, Muredach P.; Rader, Daniel J.

doi:10.1161/circulationaha.107.707349

Cited by 98 publications

(109 citation statements)

References 57 publications

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“…In three studies, experimental results were reported as means and data ranges instead of means and standard deviations. 45,48,55 For the purpose of data plotting, we calculated standard deviations for those studies by dividing the difference between the reported maximum and minimum values by 4. This estimation did not impact on the correlation analysis.…”

Section: Discussionmentioning

confidence: 99%

“…There was also limited information available (six groups) on the plasma IL-6 level of healthy adult men (Figure 4a). 29,34,45,46 The Pearson's correlation was 0.62 for the male IL-6 to BMI correlation analysis (P40.05, not significant). The regression analysis of female IL-6 to BMI was based on data from eight groups Table 1.…”

Section: Analyses Of Tnfa and Il-6mentioning

confidence: 93%

“…29,34,[45][46][47][48][49][50][51][52][53][54][55] Female data were compiled from 15 studies (26 groups of individuals), with study sample size ranging from 8 to 662 individuals and a mean sample size of 94. 29,45,46,48,50,[53][54][55][56][57][58][59][60][61][62] Lack of BMI-adiponectin association S-M Kuo and MM Halpern Among these studies, eight studies included subjects of both genders and the measurements from men and women were reported separately. The sample size as well as the age and BMI profiles of these studies are summarized in Table 1.…”

Section: Data Collectionmentioning

confidence: 99%

“…Some studies we compiled reported both plasma leptin and adiponectin measurements, thus allowing the correlation analysis between adiponectin and leptin. The regression analysis of male adiponectin to leptin was performed on data from seven groups 45,47,49,50,53,54 and Pearson's correlation was 0.53 (P40.05, not significant).…”

Section: Lack Of Bmi-adiponectin Association S-m Kuo and MM Halpernmentioning

confidence: 99%

“…The regression analysis of female adiponectin to leptin was based on data from 13 groups 45,50,53,54,56,58,61,62 and Pearson's correlation was 0.37 (P40.05, not significant). The analysis confirmed the expected lack of correlation between adiponectin and leptin in healthy individuals.…”

Section: Lack Of Bmi-adiponectin Association S-m Kuo and MM Halpernmentioning

confidence: 99%

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Lack of association between body mass index and plasma adiponectin levels in healthy adults

Kuo

2011

Int J Obes

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Objectives: To test the hypothesis that obesity (increase in fat mass) independently affects the level of adipokines: adiponectin, tumor necrosis factor-a (TNFa) and interleukin (IL)-6. Methods: Publications in the past decade reporting adult plasma adiponectin, leptin, TNFa and/or IL-6 levels were compiled. Mean gender-specific values were extracted from studies that included medical screening to confirm physical health (43 groups, total 4852 subjects). Correlation analysis was conducted between adipokine levels and body mass index (BMI), a widely used estimate of adiposity. Results: For healthy lean to obese adults of both genders, no significant correlation between plasma adiponectin and BMI was detected. There was also no gender difference in plasma adiponectin level. In contrast, leptin levels showed a positive correlation with BMI in both genders, and women had significantly higher levels of plasma leptin consistent with a higher percentage of body fat. The proinflammatory cytokine TNFa failed to show correlation with BMI. Although IL-6 showed a positive correlation with BMI in women, the obesity-related increase was very limited. Conclusions: Data analysis based on studies performed on healthy adults did not support the hypothesis that obesity independently affects the plasma level of adiponectin and TNFa. Reported obesity-related changes in plasma adipokine levels may be a consequence of obesity-related metabolic disorders. Future studies are especially needed to understand the homeostasis of adiponectin.

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Section: Discussionmentioning

confidence: 99%

Section: Analyses Of Tnfa and Il-6mentioning

confidence: 93%

Section: Data Collectionmentioning

confidence: 99%

Section: Lack Of Bmi-adiponectin Association S-m Kuo and MM Halpernmentioning

confidence: 99%

Section: Lack Of Bmi-adiponectin Association S-m Kuo and MM Halpernmentioning

confidence: 99%

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Lack of association between body mass index and plasma adiponectin levels in healthy adults

Kuo

2011

Int J Obes

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Atherosclerosis II : HDL Elevation

Ali

Hunt

Sinclair

2010

Burger's Medicinal Chemistry and Drug Discovery

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Atherosclerosis is an arterial disease associated with elevated plasma lipid levels and is a major cause of morbidity and mortality worldwide. Clinical trials have demonstrated that reduction of low‐density lipoprotein cholesterol (LDL‐C), as can be accomplished with HMG‐CoA reductase inhibitors (statins), leads to a reduction in coronary events and mortality by about 25%. Conversely, epidemiological evidence indicates that high‐density lipoprotein cholesterol (HDL‐C) levels have an inverse correlation with risk of coronary artery disease. The beneficial effects of HDL have been attributed to its involvement in the movement of cholesterol from the periphery to the liver as well as to its apparent antioxidant and anti‐inflammatory activities. Consequently, there is much interest in identifying therapeutic approaches to raising HDL that will be useful as a treatment for atherosclerosis and dyslipidemias. The properties and physiologic role of HDL, as well as approaches to increasing plasma HDL concentrations, will be summarized.

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Extracellular Phospholipases

Tietge¹

2015

Atherosclerosis

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Endothelial Lipase Is Increased In Vivo by Inflammation in Humans

Cited by 98 publications

References 57 publications

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Atherosclerosis II : HDL Elevation

Extracellular Phospholipases

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