Endothelial microparticles: a universal marker of vascular health?

Shantsila, Eduard

doi:10.1038/jhh.2008.138

Cited by 20 publications

(20 citation statements)

References 24 publications

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“…This insight into molecular pathology differentiates EMPs from functional vascular health measurements, such as flow-mediated dilatation on ultrasound or acetylcholine infusion during angiography or biological markers like soluble proteins, which provide information on singular aspects of endothelial function. 42 The value of EMPs is that they may provide a comprehensive index of endothelial homeostasis, reflective of the parent cellular state. The biogenesis and biology of function on the endothelium are critical aspects.…”

Section: Emps As Active Players In Vascular Disordersmentioning

confidence: 99%

Endothelial microparticles: Sophisticated vesicles modulating vascular function

et al. 2013

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Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.

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Section: Emps As Active Players In Vascular Disordersmentioning

confidence: 99%

Endothelial microparticles: Sophisticated vesicles modulating vascular function

et al. 2013

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“…For this reason, circulating MP play an important role in the development of cardiovascular disease [7], with increased concentrations a feature of conditions that involve vascular impairment [1,4,[8][9][10][11][12][13][14]. Consequently, MP may act as markers of vascular health or even prognostic markers for atherosclerotic disease [15][16][17]. Increased concentrations of platelet-derived MP (PMP) have also been observed in type 2 diabetes [10,13,18], but whether MP from other sources, including those from leukocytes (LMP) and monocytes (MMP), are also changed is not known.…”

Section: Introductionmentioning

confidence: 99%

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Zhang

McGeoch

Johnstone

et al. 2013

J Thromb Thrombolysis

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This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P < 0.001), P-selectin-positive (P = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.

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“…In fact, infiltration of subintima by low-density lipoproteins may induce the production of free radicals that is crucial for oxidation of the cytoskeleton and membrane proteins of endothelial cells [38]. Membrane vesiculation is considered a mechanism of elimination of oxidative stress products, including carbonylated proteins, oxidized lipoproteins, and intermediates [39]. Therefore, this oxidative-driven vesiculation of endothelial cells may relate to low-intensity inflammation in vasculature [12,40], which is associated with the overproduction of cytokines, i.e., hs-CRP, OPG, and adiponectin.…”

Section: Discussionmentioning

confidence: 99%