Endothelial Nitric Oxide Synthase and Angiotensinogen Gene Polymorphism in Coronary Artery Diseases in Egypt

Motawi, Tarek K.; Shaker, Olfat G.; Taha, Mohamed; Sedrak, Heba; Nabil, Mai M.

doi:10.1177/0003319710373094

Cited by 18 publications

(20 citation statements)

References 26 publications

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“…41 Other independent studies have also reported that the AGT TT genotype was significantly elevated in Egyptian CAD patients compared to controls. 42, 43 In Tunisians, rs699 (M235T), and rs4762 (T174M) were also associated with CAD. 44 The Glu298Asp polymorphism in exon 7 of the nitric oxide synthase 3 ( eNOS ) gene was more frequently observed in Egyptians with CAD than controls.…”

Section: Genetics Of Cvd In Africamentioning

confidence: 95%

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Genetic Epidemiology of Type 2 Diabetes and Cardiovascular Diseases in Africa

Tekola‐Ayele¹,

Adeyemo²,

Rotimi³

2013

Progress in Cardiovascular Diseases

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The burdens of type 2 diabetes (T2D) and cardiovascular diseases (CVD) are increasingin Africa. T2D and CVD are the result of the complex interaction between inherited characteristics, lifestyle, and environmental factors. The epidemic of obesity is largely behind the exploding global incidence of T2D. However, not all obese individuals develop diabetes and positive family history is a powerful risk factor for diabetes and CVD. Recent implementations of high throughput genotyping and sequencing approaches have advanced our understanding of the genetic basis of diabetes and CVD by identifying several genomic loci that were not previously linked to the pathobiology of these diseases. However, African populations have not been adequately represented in these global genomic efforts. Here, we summarize the state of knowledge of the genetic epidemiology of T2D and CVD in Africa and highlight new genomic initiatives that promise to inform disease etiology, public health and clinical medicine in Africa.

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Section: Genetics Of Cvd In Africamentioning

confidence: 95%

“…44 The Glu298Asp polymorphism in exon 7 of the nitric oxide synthase 3 ( eNOS ) gene was more frequently observed in Egyptians with CAD than controls. 43 …”

Section: Genetics Of Cvd In Africamentioning

confidence: 99%

Genetic Epidemiology of Type 2 Diabetes and Cardiovascular Diseases in Africa

Tekola‐Ayele¹,

Adeyemo²,

Rotimi³

2013

Progress in Cardiovascular Diseases

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“…A total of 18 studies were conducted in the Asian population (7,16,20,21,23,25,26,(33)(34)(35)(36)(37)41,42,45,48,51,52) and 21 in the non-Asian population (17-19,22,24,27-32,38-40, 43,44,46,47,49-50). In terms of the source of the controls, 15 were from hosptial-based (HB) studies (16,17,20,24,25,28,30,34,35,37,41,43,45,47,51) and 24 were from population-based (PB) studies (7,18,19,(21)(22)(23)26,27,29,(31)(32)(33)36,(38)(39)…”

Section: Study Characteristicsmentioning

confidence: 99%

Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta-analysis of 39 case-control studies

Gao

Zeng

Wang

et al. 2013

Molecular Medicine Reports

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Abstract. Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent. The present meta-analysis aimed to evaluate the precise result by searching the PubMed database and using 39 case-control studies comprising 7489 cases and 7051 controls.Each study tested the association between the eNOS Glu298Asp polymorphism and CHD. A meta-analysis was then conducted using the Comprehensive Meta Analysis 2.2 software to calculate the pooled odds ratios (ORs) of five genetic models with 95% confidence intervals (CIs). Publication bias was also explored. The meta-analysis showed a significant association between the eNOS Glu298Asp polymorphism and CHD susceptibility for all the genetic models [Asp vs. Glu, OR 1.26, 95% CI 1.14-1.40, P<0.001; Asp/Asp vs. Glu/Glu, OR 1.58, 95% CI 1.23-2.02, P<0.001; Glu/Asp vs. Glu/Glu, OR 1.12, 95% CI 1.03-1.22, P=0.001; (Glu/Asp+Asp/Asp) vs. Glu/ Glu, OR 1.17, 95% CI 1.07-1.27, P<0.001; Asp/Asp vs. (Glu/ Glu+Glu/Asp), OR 1.59, 95% CI 1.25-2.03, P<0.001]. Subgroup and sensitivity analyses indicated that the result was robust. A weak publication bias was detected. The results indicated that the eNOS Glu298Asp polymorphism is a risk factor for developing CHD, particularly in the Asian population.

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“…Three comparisons (Motawi et al ,10 Atay e t al 19 and Sakar et al 21) were identified as the main contributors to the heterogeneity by using Galbraith plot. The MD value and 95% CI (MD −0.13 μmol/L, 95% CI −0.22 to −0.04 μmol/L, p heterogeneity =0.89, p MD <0.001) did not change substantially after excluding these outlier comparisons (table 2).…”

Section: Resultsmentioning

confidence: 99%

Associations of theNOS3rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis

Wang

Jia

et al. 2019

Postgraduate Medical Journal

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BackgroundCirculating nitric oxide (NO) and lipid levels are closely associated with coronary artery disease (CAD). It is unclear whether the rs1799983 polymorphism in endothelial nitric oxide synthase (NOS3) gene is associated with plasma levels of NO and lipids. This systematic review and meta-analysis (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) aimed to clarify the relationships between the rs1799983 polymorphism and plasma levels of NO and lipids.MethodsSixteen studies (2702 subjects) and 59 studies (14 148 subjects) were identified for the association analyses for NO and lipids, respectively. Mean difference (MD) and 95% CI were used to estimate the effects of the rs1799983 polymorphism on plasma NO and lipid levels. The primary outcome variable was NO, and the secondary outcomes included triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).ResultsCarriers of the T allele had lower levels of NO (MD −0.27 μmol/L, 95% CI −0.42 to −0.12 μmol/L, p<0.001) and HDL-C (MD −0.07 mmol/L, 95% CI −0.14 to −0.00 mmol/L, p=0.04), and higher levels of TC (MD 0.13 mmol/L, 95% CI 0.06 to 0.20 mmol/L, p<0.001) and LDL-C (MD 0.14 mmol/L, 95% CI 0.05 to 0.22 mmol/L, p=0.002) than the non-carriers. Triglyceride levels were comparable between the genotypes.ConclusionThe association between the NOS3 rs1799983 polymorphism and CAD may be partly mediated by abnormal NO and lipid levels caused by the T allele.

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Endothelial Nitric Oxide Synthase and Angiotensinogen Gene Polymorphism in Coronary Artery Diseases in Egypt

Cited by 18 publications

References 26 publications

Genetic Epidemiology of Type 2 Diabetes and Cardiovascular Diseases in Africa

Genetic Epidemiology of Type 2 Diabetes and Cardiovascular Diseases in Africa

Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta-analysis of 39 case-control studies

Associations of theNOS3rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis

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