Endothelial nitric oxide synthase genetic variation and essential hypertension risk in Han Chinese: the Fangshan study

Wq, Niu; Qi, Yue; Lt, Zhang; Qi, YX; Wang, B; Sq, Hou; Xy, Zhai; Cc, Qiu

doi:10.1038/jhh.2008.111

Cited by 12 publications

(11 citation statements)

References 11 publications

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“…China is a united multiracial nation with the largest population in the world. We only selected the relatively homogeneous Han Chinese in our study to enhance statistical power and reduce genetic heterogeneity (Niu et al, 2009). By searching for articles from electronic databases in Chinese and English, this analysis comprised 11,037 participants, providing the most comprehensive evaluation on the association between eNOS variants and hypertension in Han Chinese so far.…”

Section: Discussionmentioning

confidence: 99%

“…Nine articles stated that cases and controls were age-and gender-matched (Huang et al, 2002;Liu and Ha, 2002;Tan et al, 2003;Zhao X et al, 2005;Li et al, 2004Li et al, , 2006Liang et al, 2006;Zhao Q et al, 2006;Yuan et al, 2007). Only one article mentioned blindness to the case-control status (Niu et al, 2009). In two studies on G894T (Tan et al, 2003;Niu et al, 2009), one on 4b/a (Yuan et al, 2007) and two on T-786C (Ma et al, 2006;Niu et al, 2009), the distribution of the genotypes in the control group was not in HWE (P < 0.05), indicating genotyping errors and/or selection bias in the recruitment of controls (Zintzaras and Lau, 2008).…”

Section: Literature Search and Meta-analysis Databasesmentioning

confidence: 99%

“…Among the 19 studies, 8 dealt with G894T (Liu and Ha, 2002;Tan et al, 2003;Li DB et al, 2004;Liang et al, 2006;Ma et al, 2006;Zhao et al, 2006;Li DJ et al, 2009;Niu et al, 2009), 7 with 4b/a (Huang et al, 2002;Li et al, 2003;Zhao X et al, 2005;Zhao Q et al, 2006;Yuan et al, 2007;Niu et al, 2009;Wu and Huang, 2009) and 4 with T-786C Ma et al, 2006;Zhao et al, 2006;Niu et al, 2009). One article provided data for males and females, respectively (Ma et al, 2006).…”

Section: Literature Search and Meta-analysis Databasesmentioning

confidence: 99%

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Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese

Wang¹,

Wang²,

Chang³

et al. 2010

Genet. Mol. Res.

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ABSTRACT.We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR) FE = 1.26, 95% confidence interval (CI) = 1.10-1.44; a vs b allele: OR FE = 1.23, 95%CI: 1.09-1.40). Four studies with sample sizes over 500 produced similar results. No evidence of publication bias was found. Also, no significant heterogeneity was observed among these studies. When we examined 1897 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 9 (3): 1896-1907 (2010) eNOS polymorphisms and essential hypertension in Han Chinese the G894T polymorphism, we found a marginally significant association for allele contrast and the recessive model when all the eligible studies were pooled together. However, there was no evidence for a significant association after the exclusion of two studies deviating from HardyWeinberg equilibrium in the control group. Heterogeneity among studies was observed. Results of cumulative and recursive cumulative meta-analysis indicated that more studies are needed to objectively determine the effects of these two polymorphisms.

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Section: Discussionmentioning

confidence: 99%

Section: Literature Search and Meta-analysis Databasesmentioning

confidence: 99%

Section: Literature Search and Meta-analysis Databasesmentioning

confidence: 99%

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Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese

Wang¹,

Wang²,

Chang³

et al. 2010

Genet. Mol. Res.

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“…This is the first systematic study of the association between the C677T polymorphism and CHD risk in Han Chinese using the meta-analysis, and the results revealed that the maternal C677T polymorphism in the MTHFR gene were significantly associated with the susceptibility of CHDs (CC vs TT: OR = 0.65, 95%CI = 0.44-0.96). We only selected the relatively homogeneous Han Chinese in our study to enhance statistical power and reduce genetic heterogeneity (Niu et al, 2009). To date, our study with an analysis of 1089 participants, provides the most comprehensive evaluation on the association between the maternal C677T variant and CHDs in Han Chinese.…”

Section: Discussionmentioning

confidence: 99%

Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis

Chen

Chen²,

Li³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relationship between the C677T polymorphism and CHDs were analyzed by meta-analysis, upon database search. The fixed-effect model or random-effect model was selected to calculate the pooled odds ratio (ORs) and its corresponding 95% confidence interval (95%CI) when appropriate. The Begg test was used to measure publication bias. Sensitivity analyses were performed to insure authenticity of the outcome. Meta-analysis of the results showed significant associations between the maternal C677T polymorphism and CHD risk (CC vs TT: OR = 0.65, 95%CI = 0.44-0.96). Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium and the results indicate that the meta-analysis was statistically significant. Results of Begg's funnel plot showed that there was no publication bias (all P > 0.05). The present meta-analysis suggested C677T polymorphism and congenital heart defects that the maternal C677T polymorphism is a risk factor for CHDs in the Chinese Han population.

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“…23,24 Indeed, persistent endothelial dysfunction itself may lead the progression of cardiovascular perturbations independently of the current BP values, such as increased arterial stiffness and vascular inflammation. 25 Vascular inflammation has been demonstrated in arterial hypertension, and inflammationrelated upregulation of endothelial adhesion molecules is an early stage in atherogenesis.…”

Section: Endothelial Dysfunction and Bp Controlmentioning

confidence: 99%

Endothelial dysfunction and diurnal variation of blood pressure: night secrets of arterial hypertension?

Shantsila

2011

J Hum Hypertens

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Endothelial nitric oxide synthase genetic variation and essential hypertension risk in Han Chinese: the Fangshan study

Cited by 12 publications

References 11 publications

Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese

Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese

Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis

Endothelial dysfunction and diurnal variation of blood pressure: night secrets of arterial hypertension?

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