Endothelial progenitor cell capturing stent and short dual antiplatelet therapy in patients on chronic anti-vitamin k regimen undergoing percutaneous coronary interventions: long-term outcomes of a single centre registry

Martín-Yuste, Victoria; Brugaletta, Salvatore; Ferreira‐González, Ignacio; Cola, Clarissa; Álvarez-Contreras, Luis; Antonio, Marta de; Martı́, Vicens; García-Picart, Joan; Sabaté, Manel

doi:10.4244/eijv6i7a143

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…This high rate of MACE has been explained by the high-risk profile of this population, with co-morbid conditions and subsequently high risk of ischemic and bleeding events [10][11][12]. The present sub-analysis from e-SELECT registry confirms this higher rate of MACE in VKA patients as compared to non-VKA patients, further supporting the role of baseline clinical profile (high Charlson index) in determining their worse clinical outcome [9]. It is noteworthy that whereas no differences in MACE or bleeding events were present between the two groups at 1-month follow-up, they became evident at 6 months, suggesting that these events need mid-time follow-up to accrue in patients VKA-treated.…”

Section: Discussionsupporting

confidence: 76%

“…Previous studies in patients with atrial fibrillation under VKA treatment and receiving PCI have shown a MACE rate around 23% and 36% at 1 and 2 years follow-up [7][8][9]. This high rate of MACE has been explained by the high-risk profile of this population, with co-morbid conditions and subsequently high risk of ischemic and bleeding events [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

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Drug eluting stent implantation in patients requiring concomitant vitamin K antagonist therapy. One-year outcome of the worldwide e-SELECT registry

Sabaté

Brugaletta

Abizaid

et al. 2013

International Journal of Cardiology

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Background: Outcome of sirolimus-eluting stent (SES) in patients treated with an antivitamin K (VKA) agent before the PCI procedure is unknown. Methods: A total of 7651 patients were selected among 15,147 recipients of SES, included in the worldwide e-SELECT registry, only from those centers which included at least one patient requiring VKA: 296 were pretreated with a VKA agent (VKA group), whereas 7355 patients from the same enrolling medical centers were not (NON-VKA group). The rates of 1) major adverse cardiac events (MACE), including all-cause deaths, myocardial infarction (MI) and target lesion revascularization, 2) stent thrombosis (ST) and 3) major bleeding (MB) in the 2 study groups were compared at 1, 6 and 12 months. Results: The patients in VKA group were on average older as compared to those in NON-VKA group (67.7 ± 9.9 vs.62.9 ± 10.7, P b 0.001). The indications for pre-procedural anticoagulation were atrial fibrillation in 177 (59.8%), presence of a prosthetic valve in 21 (7.1%), embolization of cardiac origin in 17 (5.7%), pulmonary embolism or deep vein thrombosis in 17 (5.7%), and miscellaneous diagnoses in 64 (21.6%) patients. At 1 year, the rates of MACE and MB were higher in the VKA vs. the NON-VKA group (8.3% and 3% vs. 5.3% and 1.2%, P b 0.04and P b 0.002, respectively). The 1-year rates of definite and probable ST were remarkably low in both groups (0.38% vs. 1.1%, p = 0.4). Conclusions: Selected patients anticoagulated with VKA agent may safely undergo SES implantation. Those patients may receive a variety of APT regimen at the cost of a moderate increased risk of MB.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Drug eluting stent implantation in patients requiring concomitant vitamin K antagonist therapy. One-year outcome of the worldwide e-SELECT registry

Sabaté

Brugaletta

Abizaid

et al. 2013

International Journal of Cardiology

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“…ECS application only promoted the repair of damaged endothelium, which in turn could prevent in‐stent thrombosis. Studies have shown that for patients with coronary artery diseases who could not tolerate or who were allergic to the long‐term dual antiplatelet drugs, ECS use was a safe and effective treatment method . Therefore, the ECS is a practical choice in patients with coronary artery diseases who cannot take dual antiplatelet drugs for reasons such as a planned surgery in the near future or a coagulation disorder.…”

Section: Discussionmentioning

confidence: 99%

A Meta‐Analysis of the Impact of EPC Capture Stent on the Clinical Outcomes in Patients with Coronary Artery Disease

Liu

Peng

et al. 2013

J Interven Cardiology

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“…Patients who had diabetes (16), dyslipidemia, intractable hypertension coronary heart disease, kidney disease (17), or hemorrhage disease (18) were classified as exclusions. No estrogen or anticoagulant agents were used in either group due to their potential influence on EPC levels (19,20). …”

Section: Methodsmentioning

confidence: 99%

The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma

Song¹,

Wang²,

Liu³

et al. 2013

Clinics

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OBJECTIVES:The onset of chronic subdural hematoma may be associated with direct or indirect minor injuries to the head or a poorly repaired vascular injury. Endothelial progenitor cells happen to be one of the key factors involved in hemostasis and vascular repair. This study was designed to observe the levels of endothelial progenitor cells, white blood cells, platelets, and other indicators in the peripheral blood of patients diagnosed with chronic subdural hematoma to determine the possible relationship between the endothelial progenitor cells and the occurrence, development, and outcomes of chronic subdural hematoma.METHOD:We enrolled 30 patients with diagnosed chronic subdural hematoma by computer tomography scanning and operating procedure at Tianjin Medical University General Hospital from July 2009 to July 2011. Meanwhile, we collected 30 cases of peripheral blood samples from healthy volunteers over the age of 50. Approximately 2 ml of blood was taken from veins of the elbow to test the peripheral blood routine and coagulation function. The content of endothelial progenitor cells in peripheral blood mononuclear cells was determined by flow cytometry.RESULTS:The level of endothelial progenitor cells in peripheral blood was significantly lower in preoperational patients with chronic subdural hematomas than in controls. There were no significant differences between the two groups regarding the blood routine and coagulation function. However, the levels of circulating endothelial progenitor cells were significantly different between the recurrent group and the non-recurrent group.CONCLUSIONS:The level of circulating endothelial progenitor cells in chronic subdural hematoma patients was significantly lower than the level in healthy controls. Meanwhile, the level of endothelial progenitor cells in recurrent patients was significantly lower than the level in patients without recurrence. Endothelial progenitor cells may be related to the occurrence and recurrence of chronic subdural hematoma.

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Endothelial progenitor cell capturing stent and short dual antiplatelet therapy in patients on chronic anti-vitamin k regimen undergoing percutaneous coronary interventions: long-term outcomes of a single centre registry

Abstract: Patients on AVK treatment represent a highly comorbid population with a high event rate after PCI. The strategy of PCI with an EPC capture stent and short duration of DAT may be used in patients who need a short-term DAT.

Cited by 8 publications

References 26 publications

Drug eluting stent implantation in patients requiring concomitant vitamin K antagonist therapy. One-year outcome of the worldwide e-SELECT registry

Drug eluting stent implantation in patients requiring concomitant vitamin K antagonist therapy. One-year outcome of the worldwide e-SELECT registry

A Meta‐Analysis of the Impact of EPC Capture Stent on the Clinical Outcomes in Patients with Coronary Artery Disease

The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma

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