Endothelial progenitor cells in sudden sensorineural hearing loss

Quaranta, Nicola; Ramunni, Alfonso; Luca, Concetta De; Brescia, Paola; Dambra, Porzia; Tullio, Giacomina De; Vacca, Angelo; Quaranta, A

doi:10.3109/00016489.2010.536990

Cited by 20 publications

(19 citation statements)

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“…The aetiology of ISSHL is still unclear and there are different hypothesis about risk factors for this condition [ 3 ]. We have previously demonstrated an increased expression of adhesion molecules, a reduced percentage of circulating endothelial progenitor cells and an altered FMD in ISSHL patients as early signs of endothelial damage [ 7 , 8 , 9 ]. We have hypothesized that the endothelial dysfunction could predispose to the development of a pro-thrombotic state at the level of the inner ear and considering that the cochlear vascular tree is a terminal type, an interruption of vascular flow due to endothelial damage impairs cochlear membrane functions.…”

Section: Discussionmentioning

confidence: 99%

“…Rudack et al [ 6 ] have reported that elevated fibrinogen levels, smoking and the glycoprotein Ia C807T polymorphism are associated with an increased risk for this syndrome. Our group has previously reported that patients affected by ISSHL present higher serum levels of circulating adhesion molecules (sICAM-1 and sVCAM-1) [ 7 ], a reduced percentage of circulating endothelial progenitor cells [ 8 ] and an altered flow-mediated-dilatation (FMD) [ 9 ] as clear early markers of endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss

et al. 2015

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Idiopathic sudden sensorineural hearing loss (ISSHL) is a common otologic emergency whose cause is still unclear. The importance of blood lipids in the pathogenesis of ISSHL is widely reported in literature. In fact elevated levels of low density lipoprotein cholesterol (LDL), total cholesterol (TC) and apolipoprotein B (Apo-B) have been proposed as risk factors for this pathology. No correlation has been described between serum lipid parameters and the prognosis of ISSHL. Aim of the present study was to identify prognostic factors associated with hearing recovery in a group of patients affected by ISSHL. Ninety-four patients with the diagnosis of ISSHL hospitalized between March 2013 and October 2014 were included in this study. Patients’ blood sampling and hearing assessments were carried out. Patients were divided into two groups as “recovered” and “unrecovered”, according to their response to the treatment. We found a statistically significant higher level of total cholesterol in the unrecovered group compared to the recovered one (p = 0.03). None of the other routine laboratory parameters have shown a statistically significant difference between the patients successfully treated and patients with poor outcomes. Total cholesterol concentrations may be a prognostic factor for recovery in ISSHL and should be assessed together with routine tests in patients with this condition. The other routine laboratory parameters seem to have no effect on the development and prognosis of this pathology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss

et al. 2015

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“…As is known, the blood supply to the inner ear is a terminal circulation and given the lack of collateral circulation, any even partial occlusion of the AICA (anterior inferior cerebellar artery) or VBA (vertebrobasilar artery) can cause an ischaemic event in the inner ear 11 . Recently, patients with idiopathic sudden hearing loss were shown to have significantly lower flow-mediated dilation of the brachial artery than controls (5.6 ± 1.6 vs. 7.7 ± 3.7; p < 0.01) 14 , significantly lower levels (p = 0.018) of endothelial progenitor cells 15 and increased plasma levels of adhesion molecules, which is an early sign of endothelial dysfunction 16 .…”

Section: Discussionmentioning

confidence: 99%

Italian survey on benign paroxysmal positional vertigo

Messina¹,

Casani

Manfrin

et al. 2017

Acta Otorhinolaryngol Ital

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La vertigine parossistica posizionale benigna (VPPB) è il tipo più comune di vertigine periferica. Frequentemente dopo il primo episodio la VPPB presenta recidive, con un tasso di ricorrenza tra il 15% ed il 50%. Ad oggi non vi è chiarezza sui processi eziopatogenetici che portano al distacco degli otoconi né su quali siano i fattori che rendono la VPPB una patologia recidivante, ma recenti studi epidemiologici hanno evidenziato una possibile associazione con fattori di rischio cardiovascolari. Lo scopo del presente studio (Sesto Senso Survey) è stato quello di valutare nella popolazione italiana, attraverso unindagine osservazionale, le principali caratteristiche demografiche e cliniche dei pazienti con VPPB (primo episodio o ricorrente), con particolare attenzione ai potenziali fattori di rischio cardiovascolare. Lindagine è stata condotta in 158 centri di Vestibologia in tutta Italia su 2.682 pazienti (età media 59,3 ± 15,0 anni; 39,1 maschi e 60,9% femmine) affetti da VPPB, da gennaio 2013 a dicembre 2014. I risultati hanno mostrato in questi pazienti lalta prevalenza di fattori di rischio cardiovascolari come ipertensione arteriosa (55,8%), ipercolesterolemia (38,6%) e diabete (17,7%), oltre ad una elevata familiarità per malattie cardiovascolari (49,4%). In unelevata percentuale di pazienti si è inoltre registrata la presenza di ipoacusia (42,9%), acufeni (41,2%) o entrambi (26,8%). Significativamente correlata agli episodi di recidiva di VPPB è risultata la presenza di ipertensione arteriosa, dislipidemia e comorbidità cardiovascolare accertata (range OR tra 1,84 e 2,31). Rilevanti anche le associazioni con diabete e patologie tiroidee e autoimmuni (range OR tra 1,73 e 1,89). I risultati dellindagine confermano la significativa associazione tra comorbidità cardiovascolari e VPPB recidivanti e le identificano come importante potenziale fattore di rischio per le recidive di VPPB nella popolazione italiana, aprendo la strada alla valutazione di nuove strategie terapeutiche nel trattamento di questa patologia.

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“…While we already know that these cells are reduced in patients with vascular risk factors, this study confirmed that endothelial dysfunction is involved in the creation of SSNHL and the presence of vascular damage in patients supported. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction in patients with sudden sensorineural hearing loss

et al. 2016

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Background:Endothelial dysfunction probably has a role in the etiology of sudden sensorineural hearing loss (SSNHL). The aim of this study was determining of the relationship between endothelial dysfunction and SSNHL.Materials and Methods:In a case–control study, 30 patients with SSNHL and 30 otherwise healthy age and sex-matched controls were studied. Demographic data gathered included age, gender, family history of SSNHL, and history of smoking, cardiovascular disease, hypertension, diabetes, and dyslipidemia. Laboratory data included measurement of hemoglobin, fasting blood sugar (FBS) and lipid profile. Endothelial function was assessed by measuring flow-mediated dilation (FMD).Results:The two groups were the same in age (47.9 ± 9.3 and 48.1 ± 9.6 years, P = 0.946) with female/male ratio of 1:1 in both groups. Diabetes and dyslipidemia were more frequent in patients than controls (20% vs. 0%, P = 0.024). Brachial artery diameter was greater in patients than controls before (4.24 ± 0.39 vs. 3.84 ± 0.23 mm, P < 0.001) and after ischemia (4.51 ± 0.43 vs. 4.28 ± 0.27 mm, P = 0.020), but FMD was lower in patients than controls (6.21 ± 3.0 vs. 11.52 ± 2.30%, P < 0.001). Binary logistic regression analysis showed that FMD was associated with SSNHL independent from FBS and lipid profile (odds ratio [95% confidence interval] =0.439 [0.260–0.740], P = 0.002).Conclusion:Endothelial dysfunction, among other cardiovascular risk factors, is associated with SSNHL. This association is independent from other cardiovascular risk factors including diabetes and dyslipidemia.

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Endothelial progenitor cells in sudden sensorineural hearing loss

Abstract: Circulating levels of EPCs were significantly lower in SSHL patients compared with controls. In particular, CD34+KDR+ cells and CD34+CD133+KDR+ cells were significantly reduced (p < 0.05).

Cited by 20 publications

References 20 publications

High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss

High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss

Italian survey on benign paroxysmal positional vertigo

Endothelial dysfunction in patients with sudden sensorineural hearing loss

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