Endothelin concentrations are elevated in plasma of patients with primary and secondary hyperparathyroidism

Lakatos, Péter; Tatrai, Agnes; Földes, J; Horváth, Csaba; Makó, J; Stern, Paula H.

doi:10.1007/bf02509549

Cited by 12 publications

(7 citation statements)

References 7 publications

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“…According to some authors, this prevalence may vary from 20 to 80%. [2][3][4][5] The results of our study confirm and extend these data reported in the 30,31 (c) renal function injury; 7,8 (d) activation of the renin-angiotension-aldosterone system; [32][33][34] (e) activation of the sympathetic nervous system; 26,29 (f) activation of the endothelin 35 and adrenomedullin 36 systems.…”

Section: Discussionsupporting

confidence: 83%

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

et al. 2005

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The purpose of our study was to evaluate the behaviour of blood pressure (BP) by ambulatory monitoring of blood pressure (AMBP) in 53 patients with primary hyperparathyroidism (PHPT) compared to 100 essential hypertensive (EH) and 31 healthy subjects (HS). The correlations between calcium-phosphorus metabolism and haemodynamic parameters in all groups are included in the study. AMBP was performed using the oscillometric technique (Space-Labs, 90207, Redmond, WA, USA) and the following AMBP parameters were evaluated: average day time systolic (S) and diastolic (D) blood pressure (BP) and heart rate (HR) (when awake), average night time SBP, DBP and HR (when asleep) and average 24-h-SBP, DBP and HR. The definition of 'dipper' or 'non-dipper' subjects was established if night time SBP and DBP fall was 410% and o10%, respectively. In total, 25 PHPT patients (47.2%) were hypertensive (HT-PHPT) and 28 PHPT (52.8%) were normotensive (NT-PHPT). Mean 24-h-SBP and DBP obtained by AMBP was higher in HT-PHPT (Po0.05) and EH (Po0.05) than in NT-PHPT and HS. The multiple linear regression has shown that in PHPT-HT patients ionized calcium is an independent factor for the rise of 24-h-DBP values (r: 0.497; Po0.05) and daytime DBP values (r: 0.497; Po0.05). In 56% of HT-PHPT patients there is an absence of physiological BP nocturnal fall ('non-dipper'), which is statistically significant (Po0.05) compared with 'nondipper' EH patients (30%). In conclusion, in our study the prevalence of hypertension in PHPT was 47%. AMBP revealed that the 'non-dipping 'pattern was much higher in HT-PHPT patients in respect to EH patients.

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Section: Discussionsupporting

confidence: 83%

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

et al. 2005

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“…PTH infl uences the secretion of endothelin-1, whereas endothelin, in turn, may infl uence PTH secretion. Endothelin levels are increased in the plasma of patients with primary and secondary hyperparathyroidism [ 23 ]. Another study supports the hypothesis that hypomagnesemia and hypertension are related [ 24 ].…”

Section: Pth and Endothelial Function: The Role Of Pth In Hypertensionmentioning

confidence: 88%

Parathyroid hormone and the cardiovascular system

Fitzpatrick

Bilezikian²,

Silverberg³

2008

Curr Osteoporos Rep

102

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The classical actions of parathyroid hormone (PTH) are well recognized, but its effects on other target tissues, such as the cardiovascular system, are less appreciated. Several studies have evaluated the effects of PTH in patients with primary hyperparathyroidism in order to understand potential cardiovascular effects in terms of hypertension, cardiovascular mortality, left ventricular function, and endothelial function. We review these studies and evaluate the cellular mechanisms that may affect these outcomes.

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“…Parathyroid hormone (PTH) may directly effect the CV system, and several studies have investigated endothelial and CV risk markers in PHPT. 6,[8][9][10][11][12][13][14] However, the implications of these indices in the mild form of the disease are unknown. As stated in the report from the third international workshop on asymptomatic PHPT, a demonstration of significant reversible CV abnormalities could change the recommendation for parathyroidectomy.…”

Section: Introductionmentioning

confidence: 99%

Effect of surgery on cardiac structure and function in mild primary hyperparathyroidism

Persson

Bollerslev

Rosén

et al. 2011

Clinical Endocrinology

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Endothelin concentrations are elevated in plasma of patients with primary and secondary hyperparathyroidism

Cited by 12 publications

References 7 publications

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism

Parathyroid hormone and the cardiovascular system

Effect of surgery on cardiac structure and function in mild primary hyperparathyroidism

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