Endotoxin adsorbent using dimethylamine ligands

Yuan, Zhi; Yu, Min; Li, Jihong; Hou, Guofu; Wang, Huiyan

doi:10.1016/j.biomaterials.2004.07.027

Cited by 26 publications

(10 citation statements)

References 13 publications

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“…We also have proved in our previous studies that adsorbent with dimethylamine ligand had a special affinity with endotoxin molecule, which could efficiently removal endotoxin from endotoxemia rabbit's serum [4]. Meanwhile, few jobs were reported to investigate the adsorption mechanism and the influence between endotoxin as well as protein molecules in adsorption.…”

Section: Introductionmentioning

confidence: 94%

Studies on adsorption isotherms of endotoxin and BSA using an affinity column

Zhong

Huang

Hou

et al. 2007

Process Biochemistry

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Section: Introductionmentioning

confidence: 94%

Studies on adsorption isotherms of endotoxin and BSA using an affinity column

Zhong

Huang

Hou

et al. 2007

Process Biochemistry

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“…Additionally, better adsorption capacity of adsorbent is essential for hemoperfusion [18]. As a representative technique to prepare porous material [19], freeze-drying is used to enhance adsorption capacity of some material, such as chitosan/cellulose composite [20] and cellulose nano-fibrils [21].…”

Section: Introductionmentioning

confidence: 99%

Zn²⁺-loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn-loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying. The results may be caused by porosity of the adsorbent enlarged via freeze-drying and improved stability by coating with chitosan. In addition, the adsorbent shows better selectivity and storage stability and could be a potential adsorbent to treat prostate cancer.

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“…PMB is nephrotoxic and neurotoxic, and has quite poor hemocompatibility for thrombocytes. Furthermore, the patient has to take the risk when PMB falls off from the hollow fiber that will harm the patients' kidneys 18. On the other hand, it has been indicated that NANA exhibits antiviral effect or antiinflammatory effect.…”

Section: Introductionmentioning

confidence: 99%

Bioconjugatable Azo‐Based Dark‐Quencher Dyes: Synthesis and Application to Protease‐Activatable Far‐Red Fluorescent Probes

Chevalier

Massif

Renard

et al. 2012

Chemistry A European J

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We describe the efficient synthesis and one-step derivatization of novel, nonfluorescent azo dyes based on the Black Hole Quencher-3 (BHQ-3) scaffold. These dyes were equipped with various reactive and/or bioconjugatable groups (azido, α-iodoacetyl, ketone, terminal alkyne, vicinal diol). The azido derivative was found to be highly reactive in the context of copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions and allowed easy synthetic access to the first water-soluble (sulfonated derivative) and aldehyde-modified BHQ-3 dyes, the direct preparation of which failed by means of conventional azo-coupling reactions. The aldehyde- and α-iodoacetyl-containing fluorescence quenchers were readily conjugated to aminooxy- and cysteine-containing peptides by the formation of a stable oxime or thioether linkage, respectively. Further fluorescent labeling of the resultant peptide conjugates with red- or far-red-emitting rhodamine or cyanine dyes through sequential and/or one-pot bioconjugations, led to novel Förster resonance energy transfer (FRET) based probes suitable for the in vivo detection and imaging of urokinase plasminogen activator, a key protease in cancer invasion and metastasis.

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Endotoxin adsorbent using dimethylamine ligands

Cited by 26 publications

References 13 publications

Studies on adsorption isotherms of endotoxin and BSA using an affinity column

Studies on adsorption isotherms of endotoxin and BSA using an affinity column

Zn²⁺-loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma

Bioconjugatable Azo‐Based Dark‐Quencher Dyes: Synthesis and Application to Protease‐Activatable Far‐Red Fluorescent Probes

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Endotoxin adsorbent using dimethylamine ligands

Cited by 26 publications

References 13 publications

Studies on adsorption isotherms of endotoxin and BSA using an affinity column

Studies on adsorption isotherms of endotoxin and BSA using an affinity column

Zn2+-loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma

Bioconjugatable Azo‐Based Dark‐Quencher Dyes: Synthesis and Application to Protease‐Activatable Far‐Red Fluorescent Probes

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Product

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About

Zn²⁺-loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma